A StAR search: Implications in controlling steroidogenesis

Biology of Reproduction

Volumn 56, Issue 2, 1997, Pages 328-336

  Stocco, Douglas M ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PREGNENOLONE; STEROID HORMONE;

ARTICLE; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENE EXPRESSION REGULATION; GENE LOCUS; GLOMERULOSA CELL; HORMONAL REGULATION; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; INNER CELL MASS; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; STEROIDOGENESIS;

ANIMALS; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MUTATION; PHOSPHOPROTEINS; PREGNENOLONE; STEROIDS; ZONA GLOMERULOSA;

EID: 0031049159     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod56.2.328     Document Type: Article

References (116)

1. Strauss JF, Martinez F, Kiriakidou M. Placental steroid hormone synthesis: unique features and unanswered questions. Biol Reprod 1996; 54:303-311.
2. Mellon SH. Neurosteroids: biochemistry, modes of action, and clinical relevance. J Clin Endocrinol & Metab 1994; 78:1003-1008.
3. Simpson ER, Boyd GS. The cholesterol side-chain cleavage system of the adrenal cortex: a mixed function oxidase. Biochem Biophys Res Commun 1966; 24:10-17.
4. Simpson ER, Boyd GS. The cholesterol side-chain cleavage system of the adrenal cortex. Eur J Biochem 1967; 2:275-285.
5. Yago N, Ichii S. Submitochondrial distribution of components of the steroid 11-β-hydroxylase and cholesterol side chain-cleavage enzyme systems in hog adrenal cortex. J Biochem 1969; 65:215-224.
6. scc and P45011β in bovine adrenocortical inner mitochondrial membranes. J Biol Chem 1979; 254:10443-10448.
7. Lambeth JD, Seybert DW, Kamin H. Ionic effects on adrenal steroidogenic electron transport. The role of adrenodoxin as an electron shuttle. J Biol Chem 1979; 254:7255-7264.
8. scc. J Biol Chem 1987; 262: 10020-10025.
9. Farkash Y, Timberg R, Orly J. Preparation of antiserum to rat cytochrome P-450 cholesterol side chain cleavage, and its use for ultrastructural localization of the immunoreactive enzyme by protein A-gold technique. Endocrinology 1986; 1353-1365.
10. scc substrate interactions: studies of binding and catalytic activity using hydroxycholesterols. J Biol Chem 1982; 257: 1876-1884.
11. scc incorporated into artificial phospholipid vesicles. Int J Biochem 1984; 16:479-503.
12. Tuckey RC, Atkinson HC. Pregnenolone synthesis from cholesterol and hydroxycholesterols by mitochondria from ovaries following the stimulation of immature rats with pregnant mare's serum gonadotropin and human choriogonadotropin. Eur J Biochem 1989; 186:255-259.
13. Tuckey RC. Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates. J Steroid Biochem Mol Biol 1992; 42:883-890.
14. Waterman MR, Simpson ER. Regulation of the biosynthesis of cytochromes P-450 involved in steroid hormone synthesis. Mol Cell Biol 1985; 39:81-89.
15. Payne AH, Quinn PG, Rani CS. Regulation of microsomal cytochrome P-450 enzymes and testosterone production in Leydig cells. Recent Prog Horm Res 1985; 41:153-197.
16. Simpson ER, Waterman MR. Regulation of ACTH of steroid hormone biosynthesis in the adrenal cortex. Can J Biochem Cell Biol 1983; 61:692-707.
17. Hall PF. Cytochromes P-450 and the regulation of steroid synthesis. Steroids 1986; 48:133-196.
18. Simpson ER, Mason JI, John ME, Zuber MX, Rodgers RJ, Waterman MR. Regulation of the biosynthesis of steroidogenic enzymes. J Steroid Biochem 1987; 27:801-805.
19. Simpson ER, Waterman MR. Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. Annu Rev Physiol 1988; 50:427-440.
20. Hall PF. Testicular steroid synthesis: organization and regulation. In: Knobil E, Neill J (eds.), The Physiology of Reproduction. New York: Raven Press; 1988: 975-998.
21. Miller WL. Molecular biology of steroid hormone synthesis. Endocr Rev 1988; 9:295-318.
22. Payne AH. Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17α-hydroxylase/C17-20 lyase in Leydig cells. Biol Reprod 1990; 42:399-404.
23. Simpson E, Lauber M, Demeter M, Stirling D, Rodgers R, Means G, Mahendroo M, Kilgore M, Mendelson C, Waterman M. Regulation of expression of the genes encoding steroidogenic enzymes. J Steroid Biochem 1991; 40:45-52.
24. Simpson E, Lauber M, Demeter M, Means G, Mahendroo M, Kilgore M, Mendelson C, Waterman M. Regulation of expression of the genes encoding steroidogenic enzymes in the ovary. J Steroid Biochem 1992; 41:409-413.
25. Hanukoglu I. Steroidogenic enzymes: structure function, and role in the regulation of steroid hormone biosynthesis. J Steroid Biochem Mol Biol 1992; 43:779-804.
26. Ferguson JJ. Puromycin and adrenal responsiveness to adrenocorticotropic hormone. Biochim Biophys Acta 1962; 57:616-617.
27. Ferguson JJ. Protein synthesis and adrenocorticotropin responsiveness. J Biol Chem 1963; 238:2754-2759.
28. Garren LD, Ney RL, Davis WW. Studies on the role of protein synthesis in the regulation of corticosterone production by ACTH in vivo. Proc Natl Acad Sci USA 1965; 53:1443-1450.
29. Garren LD, Davis WW, Crocco RM. Puromycin analogs: action of adrenocorticotropic hormone and the role of glycogen. Science 1966; 152:1386-1388.
30. Davis WW, Garren LD. On the mechanism of action of adrenocorticotropic hormone. The inhibitory site of cycloheximide in the pathway of steroid biosynthesis. J Biol Chem 1968; 243:5153-5157.
31. Garren LD. The mechanism of action of adrenocorticotropic hormone. In: Harris RS, Wool IG, Loraine JA (eds.), Vitamins and Hormones. New York: Academic Press; 1968: 26:119-145.
32. Davis WW, Garren LD. Evidence for the stimulation by adrenocorticotropic hormone of the conversion of cholesterol esters to cholesterol in the adrenal, in vivo. Biochem Biophys Res Commun 1966; 24:805-810.
33. Crivello JF, Jefcoate CR. Mechanism of corticotropin action in rat adrenal cells. 1. Effect of inhibitors of protein synthesis and of microfilament formation on corticosterone synthesis. Biochim Biophys Acta 1978; 542:315-329.
34. Farese RV. Adrenocorticotrophin-induced changes in the steroidogenic activity of adrenal cell-free preparations. Biochemistry 1967; 6:2052-2065.
35. Cooke BA, Janszen FHA, Clotscher WF, van der Molen HJ. Effect of protein-synthesis inhibitors on testosterone production in rat testis interstitial tissue and Leydig-cell preparations. Biochem J 1975; 150: 413-418.
36. scc of the rat adrenal. Effect of adrenocorticotropic hormone and cycloheximide. J Biol Chem 1976; 251:7120-7126.
37. Farese RV, Prudente WJ. On the requirement for protein synthesis during corticotropin-induced stimulation of cholesterol side chain cleavage in rat adrenal mitochondrial and solubilized desmolase preparations. Biochim Biophys Acta 1977; 496:567-570.
38. Mason JI, Arthur JR, Boyd GS. Control of sterol metabolism in rat adrenal mitochondria. Biochem J 1978; 173:1045-1051.
39. Toaff ME, Strauss III JF, Flickinger GL, Shattil SJ. Relationship of cholesterol supply to luteal mitochondrial steroid synthesis. J Biol Chem 1979; 254:3977-3982.
40. Privalle CT, Crivello JF, Jefcoate CR. Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland. Proc Natl Acad Sci USA 1983; 80:702-706.
41. Stevens VL, Aw TY, Jones DP, Lambeth JD. Oxygen dependence of adrenal cortex cholesterol side chain cleavage. Implications in the rate-limiting steps in steroidogenesis. J Biol Chem 1984; 259:1174-1179.
42. Solano AR, Neger R, Podesta EJ. Rat adrenal cycloheximide-sensitive factors and phospholipids in the control of acute steroidogenesis. J Steroid Biochem 1984; 21:111-116.
43. scc. Regulation of intramitochondrial cholesterol transfer. Mol Cell Endocrinol 1987; 53:87-101.
44. McNamara BC, Jefcoate CR. Synergistic stimulation of pregnenolone synthesis in rat adrenal mitochondria by n-hexane and cardiolipin. Arch Biochem Biophys 1988; 260:780-788.
45. Stevens VL, Xu T, Lambeth JD. Cholesterol pools in rat adrenal mitochondria: use of cholesterol oxidase to infer a complex pool structure. Endocrinology 1992; 130:1557-1563.
46. Stevens VL, Xu T, Lambeth JD. Cholesterol trafficking in steroidogenic cells: reversible cycloheximide-dependent accumulation of cholesterol in a pre-steroidogenic pool. Eur J Biochem 1993; 216: 557-563.
47. Farese RV. Inhibition of the steroidogenic effect of ACTH and incorporation of amino acid into rat adrenal protein in vitro by chloramphenicol. Biochim Biophys Acta 1964; 87:701-703.
48. Stocco DM, Clark BJ. Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 1996; 17:221-244.
49. Krueger RJ, Orme-Johnson NR. Acute adrenocorticotropic hormone stimulation of adrenal corticosteroidogenesis. J Biol Chem 1983; 258:10159-10167.
50. Pon LA, Orme-Johnson NR. Acute stimulation of steroidogenesis in corpus luteum and adrenal cortex by peptide hormones: rapid induction of a similar protein in both tissues. J Biol Chem 1986; 261: 6594-6599.
51. Pon LA, Epstein LF, Orme-Johnson NR. Acute cAMP stimulation in Leydig cells: rapid accumulation of a protein similar to that detected in adrenal cortex and corpus luteum. Endocr Res 1986; 12:429-446.
52. Epstein LF, Orme-Johnson NR. Acute action of luteinizing hormone on mouse Leydig cells: accumulation of mitochondrial phosphoproteins and stimulation of testosterone biosynthesis. Mol Cell Endocrinol 1991; 81:113-126.
53. Alberta JA, Epstein LF, Pon LA, Orme-Johnson NR. Mitochondrial localization of a phosphoprotein that rapidly accumulates in adrenal cortex cells exposed to adrenocorticotropic hormone or to cAMP. J Biol Chem 1989; 264:2368-2372.
54. Epstein LF, Orme-Johnson NR. Regulation of steroid hormone biosynthesis: identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells. J Biol Chem 1991; 266:19739-19745.
55. Stocco DM, Kilgore MW. Induction of mitochondrial proteins in MA-10 Leydig tumour cells with human choriogonadotropin. Biochem J 1988; 249:95-103.
56. Stocco DM, Chaudhary LR. Evidence for the functional coupling of cAMP in MA-10 mouse Leydig tumor cells. Cell Signal 1990; 2: 161-170.
57. Stocco DM, Sodeman TC. The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors. J Biol Chem 1991; 266:19731-19738.
58. Stocco DM, Chen W. Presence of identical mitochondrial proteins in unstimulated constitutive steroid-producing R2C rat Leydig tumor and stimulated nonconstitutive steroid-producing MA-10 mouse Leydig tumor cells. Endocrinology 1991; 128:1918-1926.
59. Stocco DM. Further evidence that the mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are involved in the acute regulation of steroidogenesis. J Steroid Biochem Mol Biol 1992; 43:319-333.
60. Stocco DM, Ascoli M. The use of genetic manipulation of MA-10 Leydig tumor cells to demonstrate the role of mitochondrial proteins in the acute regulation of steroidogenesis. Endocrinology 1993; 132: 959-967.
61. Stocco DM, Clark BJ. The requirement of phosphorylation on a threonine residue in the acute regulation of steroidogenesis in MA-10 mouse Leydig cells. J Steroid Biochem Mol Biol 1993; 46:337-347.
62. Stocco DM, King S, Clark BJ. Differential effects of dimethylsulfoxide on steroidogenesis in mouse MA-10 and rat R2C Leydig tumor cells. Endocrinology 1995; 136:2993-2999.
63. Clark BJ, Wells J, King SR, Stocco DM. The purification, cloning, and expression of a novel LH-induced mitochondrial protein in MA-10 mouse Leydig tumor cells: characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem 1994; 269: 28314-28322.
64. Sugawara T, Holt JA, Driscoll D, Strauss III JF, Lin D, Miller WL, Patterson D, Clancy KP, Hart IM, Clark BJ, Stocco DM. Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the gene to 8p11.2 and a pseudogene to chromosome 13. Proc Natl Acad Sci USA 1995; 92:4778-4782.
65. Clark BJ, Soo SC, Caron KM, Ikeda Y, Parker KL, Stocco DM. Hormonal and developmental regulation of the steroidogenic acute regulatory (StAR) protein. Mol Endocrinol 1995; 9:1346-1355.
66. Juengel JL, Meberg BM, Turzillo AM, Nett TM, Niswender GD. Hormonal regulation of messenger ribonucleic acid encoding steroidogenic acute regulatory protein in ovine corpora lutea. Endocrinology 1995; 136:5423-5429.
67. Hartung S, Rust W, Balvers M, Ivell R. Molecular cloning and in vivo expression of the bovine steroidogenic acute regulatory protein. Biochem Biophys Res Commun 1995; 215:646-653.
68. Pescador N, Korian Soumano S, Stocco DM, Price CA, Murphy BD. Steroidogenic acute regulatory protein in bovine corpora lutea. Biol Reprod 1996; 55:485-491.
69. Gocze PM, Freeman DA. A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells. Endocrinology 1992; 131:2972-2978.
70. Choi YS, Stocco DM, Freeman DA. Diethylumbelliferyl phosphate inhibits steroidogenesis by interfering with a long-lived factor acting between protein kinase A activation and induction of the steroidogenic acute regulatory (StAR) protein. Eur J Biochem 1995; 234: 680-685.
71. Bosman HB, Hales KH, Li X, Liu Z, Stocco DM, Hales DB. Endotoxemia causes a dramatic and abrupt decrease in circulating testosterone levels. Endocrinology 1996; (in press).
72. Townson DH, Wang XJ, Keyes PL, Kostyo JL, Stocco DM. Expression of the steroidogenic acute regulatory protein (StAR) in the corpus luteum of the rabbit: dependence upon the luteotrophic hormone, 17β-estradiol. Biol Reprod 1996; 55:868-874.
73. Sugawara T, Lin D, Holt JD, Martin KO, Javitt NB, Miller WL, Strauss III JF. Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity. Biochemistry 1995; 34:12506-12512.
74. Waterman MR. Biochemical diversity of the cAMP-dependent transcription of steroid hydroxylase genes in the adrenal cortex. J Biol Chem 1994; 269:27783-27786.
75. Rice DA, Mouw AR, Bogerd AM, Parker KL. A shared promoter element regulates the expression of three steroidogenic enzymes. Mol Endocrinol 1991; 5:1552-1556.
76. Morohashi K, Honda S, Inomata Y, Handa H, Omura T. A common trans-acting binding factor, Ad4-binding protein, to the promoters of steroidogenic P450s. J Biol Chem 1992; 267:17913-17919.
77. Suguwara T, Holt JA, Kiriakidou M, Strauss JF. Steroidogenic factor 1-dependent promotor activity of the human steroidogenic acute regulatory protein (StAR) gene. In: Program of the 10th International Congress of Endocrinology; 1996; San Francisco, CA. Abstract OR27-2.
78. Argetsinger LS, Campbell GS, Yang X, Witthuhn BA, Silvennoinen O, Ihle JN, Carter-Su C. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 1993; 74:237-244.
79. Fleury A, Cloutier M, Ducharme L, Lefebvre A, LeHoux J, LeHoux JG. Hamster adrenal acute regulatory protein cDNA: its characterization and regulation of its expression by ACTH. In: Program of the Seventh Conference on the Adrenal Cortex; 1996; Crieff, Scotland. Abstract.
80. Hendrick JP, Hodges PE, Rosenberg LE. Survey of amino-terminal proteolytic cleavage sites in mitochondrial precursor proteins: leader peptides cleaved by two matrix proteases share a three amino acid motif. Proc Natl Acad Sci USA 1989; 86:4056-4060.
81. King SR, Ronen-Fuhrmann T, Timberg R, Clark BJ, Orly J, Stocco DM. Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein. Endocrinology 1995; 136:5165-5176.
82. Gradi A, Tang-Wai R, McBride HM, Chu LL, Shore GC, Pelletier J. The human steroidogenic acute regulatory (StAR) gene is expressed in the urogenital system and encodes a mitochondrial polypeptide. Biochim Biophys Acta 1995; 1258:228-233.
83. Elliot ME, Goodfriend TL, Jefcoate CR. Bovine adrenal glomerulosa and fasciculata cells exhibit 28.5-kilodalton proteins sensitive to angiotensin, other agonists, and atrial natriuretic peptide. Endocrinology 1993; 133:1669-1677.
84. + in H295R adrenocortical cells. Mol Cell Endocrinol 1995; 115:215-219.
85. Pezzi V, Clark BJ, Ando S, Stocco DM, Rainey WE. Role of calmodulin-dependent protein kinase II in acute adrenal aldosterone production. J Steroid Biochem Mol Biol 1996; (in press).
86. King SR, Du Y, Stocco DM. Importance of the phosphorylation state of the steroidogenic acute regulatory (StAR) protein for steroidogenesis. Biol Reprod 1996; 54(suppl):135 (abstract 548).
87. Camacho AM, Kowarski A, Migeon CJ, Brough AJ. Congenital adrenal hyperplasia due to a deficiency of one of the enzymes involved in the biosynthesis of pregnenolone. J Clin Endocrinol & Metab 1968; 28:153-161.
88. Degenhart HJ, Visser HKA, Boon H, O'Doherty NJ. Evidence for deficient 20α-cholesterol-hydroxylase activity in adrenal tissue of a patient with lipoid adrenal hyperplasia. Acta Endocrinol 1972; 71: 512-518.
89. Koizumi S, Kyoya S, Miyawaki T, Kidani H, Funabashi T, Nakashima Y, Ohta G, Itagakj E, Katagiri M. Cholesterol side-chain cleavage enzyme activity and cytochrome P450 content in adrenal mitochondria of a patient with congenital lipoid adrenal hyperplasia (Prader disease). Clin Chim Acta 1977; 77:301-306.
90. Hauffa PT, Miller WL, Grumbach MM, Conte FA, Kaplan SL. Congenital adrenal hyperplasia due to deficient cholesterol side-chain cleavage activity (20,22-desmolase) in a patient treated for 18 years. Clin Endocrinol 1985; 23:481-493.
91. scc, in congenital lipoid adrenal hyperplasia. J Clin Invest 1991; 88:1955-1962.
92. Sakai Y, Yanase T, Okabe Y, Hara T Waterman MR, Takayanagi R, Haji M, Nawata H. No mutation in cytochrome P450 side chain cleavage in a patient with congenital lipoid adrenal hyperplasia. J Clin Endocrinol & Metab 1994; 79:1198-1201.
93. Lin D, Chang YJ, Strauss III JF, Miller WL. The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. Genomics 1993; 18:643-650.
94. Saenger P, Klonari Z, Black SM, Compagnone N, Mellon SH, Fleischer A, Abrams CAL, Shackelton CHL, Miller WL. Prenatal diagnosis of congenital lipoid adrenal hyperplasia. J Clin Endocrinol & Metab 1995; 80:200-205.
95. Lin D, Sugawara T, Strauss III JF, Clark BJ, Stocco DM, Saenger P, Rogol A, Miller WL. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 1995; 267:1828-1831.
96. Miller WL. Mitochondrial specificity of the early steps in steroidogenesis. J Steroid Biochem Mol Biol 1995; 55:607-619.
97. Tee M, Lin D, Sugawara T, Holt JA, Guiguen Y, Buckingham B, Strauss III JF, Miller WL. T-A transversion 11 bp from a splice acceptor site in the human gene for steroidogenic acute regulatory protein causes congenital lipoid adrenal hyperplasia. Hum Mol Genet 1995; 4:2299-2305.
98. Portrat-Doven S, Leheup B, Chaussain YM. Three new mutations of the steroidogenic acute regulatory gene (StAR) in 2 families with congenital lipoid adrenal hyperplasia. In: Program of the 10th International Congress of Endocrinology; 1996: San Francisco, CA. Abstract P2-726.
99. Bose HS, Suguwara T, Fujieda K, Pang S, Ben-Neriah Z, Savage DCL, Winter JSD, Papadimitriou T, Muller J, Schwartz M, Strauss JF, Miller WL. Analysis of StAR protein in 14 cases of lipoid CAH. In: Program of the 10th International Congress of Endocrinology; 1996; San Francisco, CA. Abstract P2-770.
100. Katsumata N, Tanae A, Shinagawa T, Yasunaga T, Tanaka T, Hibi I. Novel mutations in the steroidogenic acute regulatory gene in Japanese patients with congenital lipoid adrenal hyperplasia. In: Program of the 10th International Congress of Endocrinology; 1996; San Francisco, CA. Abstract P3-564.
101. Reinhart MP. Intracellular sterol trafficking. Experientia 1990; 46: 599-611.
102. scc in steroid hormone synthesis. J Steroid Biochem Mol Biol 1992; 43:751-767.
103. Schwaiger M, Herzog V, Neupert W. Characterization of translocation contact sites involved in the import of mitochondrial proteins. J Cell Biol 1987; 105:235-246.
104. Vestweber D, Schatz G. A chimeric mitochondrial precursor protein with internal disulphide bridges blocks import of authentic precursors into mitochondria. A means to quantitate translocation contact sites. J Cell Biol 1988; 107:2037-2043.
105. Pon L, Moll T, Vestweber D, Marshallsay B, Schatz G. Protein import into mitochondria: ATP-dependent protein translocation activity in a submitochondrial fraction enriched in membrane contact sites and specific proteins. J Cell Biol 1989; 109:2603-2616.
106. Pfanner N, Rassow J, Wienhues U, Hergersberg C, Sollner T, Becker K, Neupert W. Contact sites between inner and outer membranes: structure and role in protein translocation into the mitochondria. Biochim Biophys Acta 1990; 1018:239-242.
107. Hwang ST, Wachter C, Schatz G. Protein import into the yeast mitochondrial matrix: a new translocation intermediate between the two mitochondrial membranes. J Biol Chem 1990; 266:21083-21089.
108. Stevens VL, Tribble DL, Lambeth JD. Regulation of mitochondrial compartment volumes in rat adrenal cortex by ether stress. Arch Biochem Biophys 1985; 242:324-327.
109. Strauss JF. Intracellular trafficking of sterols: multiple genes, similar mechanisms? In: Program of the 2nd International Symposium on Molecular Steroidogenesis; 1996; Monterey, CA. Abstract.
110. Arakane F, Suguwara T, Nishino H, Holt JA, Strauss JF. The C-terminus of StAR is critical for function, the N-terminus can be truncated. Biol Reprod 1996; 54(suppl):135 (abstract 435).
111. Cherradi N, Defaye G, Chambaz EM. Characterization of the 3β-hydroxysteroid dehydrogenase activity associated with bovine adrenocortical mitochondria. Endocrinology 1994; 134:1358-1364.
112. scc are associated in a catalytically active molecular complex in bovine adrenocortical mitochondria. In: Program of the IX International Congress on Hormonal Steroids; 1995; Dallas, TX. Abstract A171.
113. Cherradi N, Rossier MF, Vallotton MB, Stocco DM, Capponi AM. Calcium stimulates intramitochondrial cholesterol transfer and StAR protein in bovine adrenal glomerulosa cells. In: Program of the 10th International Congress of Endocrinology; 1996; San Francisco, CA. Abstract OR6-6.
114. Papadopoulos V. Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endoer Rev 1996; 14:222-240.
115. Papadopoulos V, Boujrad N, Amri H, Gamier M, Vidic B, Reversat JL, Bernassau JM, Drieu K. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. In: Program of the 2nd International Symposium on Molecular Steroidogenesis; 1996; Monterey, CA. Abstract.
116. Papadopoulos V. Benzodiazepine receptors in steroidogenesis. In: Program of the 10th International Congress of Endocrinology; 1996; San Francisco, CA. Abstract S8-2.