Effects of hormones and protein kinase inhibitors on expression of steroidogenic enzyme promoters in electroporated primary rat granulosa cells

Biology of Reproduction

Volumn 54, Issue 1, 1996, Pages 208-218

  Orly, Joseph ^b   Clemens, Jeffrey W ^a   Singer, Orna ^b   Richards, JoAnne S ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; AROMATASE; CHOLESTEROL; CYCLIC AMP; CYTOCHROME P450; DNA; ENZYME; FOLLITROPIN; FORSKOLIN; HORMONE; MESSENGER RNA; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; TYRPHOSTIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; ELECTROPORATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GRANULOSA CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMAL; AROMATASE; CELLS, CULTURED; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CHORIONIC GONADOTROPIN; ELECTROPORATION; FEMALE; FOLLICLE STIMULATING HORMONE; FORSKOLIN; GENE EXPRESSION; GRANULOSA CELLS; LUTEAL CELLS; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; RATS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION;

ANIMALIA;

EID: 0029655551     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod54.1.208     Document Type: Article

References (57)

1. Zlotkin T, Farkash Y, Orly J. Cell-specific expression of immunoreactive cholesterol side-chain cleavage cytochrome P450 during follicular development in the rat ovary Endocrinology 1986; 119 2809-2820.
2. Hickey GJ, Chen S, Besman MJ, Shivery JE, Hall PF, Gaddy-Kurten D, Richards JS Hormonal regulation, tissue distribution, and content of aromatase cytochrome P450 messenger ribonucleic acid and enzyme in rat ovarian follicles and corpora lutea: relationship to estradiol biosynthesis. Endocrinology 1988, 122:1426-1436.
3. Fitzpatrick SL, Richards JS. Regulation of cytochrome P450 aromatase messenger ribonucleic acid and activity by steroids and gonadotropins in rat granulosa cells. Endocrinology 1991; 129:1452-1462.
4. Goldring NB, Farkash Y, Goldschmit D, Orly J. Immunofluorescence probing of the mitochondrial cholesterol side-chain cleavage cytochrome P-450 expressed in differentiating granulosa cells in culture Endocrinology 1986, 119-2821-2832
5. Daniel SAJ, Armstrong DT. Enhancement of follicle-stimulating hormone-induced aromatase activity by androgens in cultured rat granulosa cells. Endocrinology 1980; 107-1027-1033
6. Hillier SG, De Zwart FA. Evidence that granulosa cell aromatase induction/activation by follicle stimulating hormone is an androgen receptor-regulated process in vitro. Endocrinology 1981, 109:1303-1305
7. Orly J Growth of functional primary and established rat ovary cell cultures in serum-free medium. In. Barnes D, Ssrbasku D, Sato G (eds.), Cell Culture Methods for Molecular and Cell Biology. New York. Liss; 1984 2.63-87.
8. scc) in rat ovarian granulosa cells and corpora lutea J Biol Chem 1989, 264 21934-21942
9. Hickey GJ, Oonk RB, Hall PF, Richards JS. Aromatase cytochrome P450 and cholesterol side-chain cleavage cytochrome P450 in corpora lutea of pregnant rats: diverse regulation by peptide and steroid hormones Endocrinology 1989; 125.1673-1682.
10. 1 in pre-pubertal, cycling, pregnant and pseudopregnant rat. Endocrinology 1976; 99 198-210.
11. Marsh JM The role of cyclic AMP in gonadal steroidogenesis. Biol Reprod 1976; 14:30-36
12. Ratoosh SL, Richards JS. Regulation of the content and phosphorylation of RII by adenosine 3′,5′-monophosphate, follicle stimulating hormone and estradiol in cultured granulosa cells. Endocrinology 1985, 117.917-927
13. Gazit A, Yaish P, Gilon C, Levitzki A Tyrphostins I Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 1989; 32:231-4-2352.
14. Yaish P, Gazit A, Gilon C, Levitzki A. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 1988; 242:933-935.
15. Gomberg-Malool S, Rei Z, Re'em Y, Posner I, Levitzki A, Orly J. Tyrphostins inhibit follicle stimulating hormone-mediated functions in cultured rat ovarian granulosa cells. Endocrinology 1993, 132:362-370.
16. Orly J, Rei Z, Greenberg N, Richards JS. Tyrosine kinase inhibitor AG18 arrests FSH induced granulosa cell differentiation: use of semi-quantitative RT-PCR assay for multiple mRNAs Endocrinology 1994; 134.2336-2346.
17. Morris JK, Richards JS. Hormone induction of luteinization and prostaglandin endoperoxicle synthase-2 involves multiple cellular signaling pathways. Endocrinology 1993; 133.770-779
18. Fitzpatrick SL, Richards JS. Cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3′,5′-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells. Mol Endocrinol 1993;7:341-354
19. Richards JS, Clemens JW, Sirois J, Fitzpatrick SL, Wong WI, Kurten RC. Hormonal control of gene expression during ovarian cell differentiation. In. Leung PCK, Hsueh AJW, Friesen HG (eds.), Molecular Basis of Reproductive Endocrinology. New York Scrono Symposia, USA. Springer-Verlag; 1993; 102-111.
20. Clemens JW, Lala DS, Parker KL, Richards JS. Steroidogenic faetor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells Endocrinology 1994; 134:1499-1508
21. Chu G, Hayakawa H, Berg P Electroporation for the efficient transfection of mammalian cells with DNA. Nucleic Acid Res 1987, 15:1311-1326.
22. Kurten RC, Richards, JS An adenosine 3′,5′-monophosphate responsive DNA element (CRE) confers forskolin sensitivity on gene expression by primary rat granulosa cells Endocrinology 1989; 125.1345-1357.
23. Orly J, Sato G, Erickson GF Serum suppresses the expression of hormonally induced functions in cultured granulosa cells Cell 1980: 20 817-827
24. Richards JS, Bogovich K Effects of human chorionic gonadotropin and progesterone on follicular development in the immature rat. Endocrinology 1987, 111.1429-1438
25. German CM, Moffat LF, Howard BH Recombinant genomes which express chloramphemcol acetyltransferase in mammalian cells Mol Cell Biol 1982; 2:1044-1051.
26. Camp TA, Rahal JO, Mayo KE Cellular localization and hormonal regulation of follicle stimulating hormone and luteinizing hormone receptor messenger RNAs in the rat ovary. Mol Endocrinol 1991; 5:1405-1417
27. Park OK, Mayo KE. Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surge. Mol Endocrinol 1991, 5-967-978.
28. Schulster D, Orly J Seidel G, Schramm M Intracellular cyclic AMP production enhanced by a hormone receptor transferred from a different cell J Biol Chem 1978; 253.1201-1206.
29. Adashi EW, Resnick CE, Hernandez ER, May JV, Knecht M, Svoboda ME, Van Wyk JJ. Insulin-like growth factor-I as an amplifier of follicle-stimulating hormone action studies on mcehanism(s) and site(s) of action in cultured rat granulosa cells Endocrinology 1988, 122-1583-1591.
30. Bitzur S, Orly J. Microanalysis of hormone responsive ovarian interstitial gland cells in miniature culture. Endocrinology 1989, 124:1471-1484
31. Ramdas L, McMurray JS, Budde RJA. The degree of inhibition of protein tyrosine kinase activity by tyrphostin 23 and 25 is related to their instability. Cancer Res 1994, 54:867-869.
32. Delegean AM, Ferland LH, Mellon PL. Tissue-specific enhancer of the human glycoprotein hormone α-subunit gene dependence on cyclic AMP-inducible elements Mol Cell Biol 1987, 7.3994
33. Silver BJ, Bokar JA, Virgin JB, Vallen EA, Milsted A, Nilson JH Cyclic AMP regulation of the human glycoprotein hormone α-subunit is mediated by an 18-base-pair element Proc Nad Acad Sci USA 1987, 84:2198.
34. Deutsch PJ, Jameson JL, Habener JF Cyclic AMP responsiveness of human gonadotropin α-gene transcription is directed by a repeated 18-base pair enhancer α-Promoter receptivity to the enhancer confers cell-preferential expression. J Biol Chem 1987; 262:12169-12174.
35. Fitzpatrick SL, Richards JS. Identification of a cyclic adenosine 3′,5′-monophosphate-response element in the rat aromatase promoter that is required for transcnptional activation in rat granulosa cells and R2C Leydig cells. Mol Endocrinol 1994; 8:1309-1319.
36. Lala DS, Rice DA, Parker KL. Steroidogenic factor I, key regulator of steroidogenic enzyme expression, is the mouse homolog of fusbi tarazu-factor I Mol Endocrinol 1992, 6.1249-1258
37. Morohashi K-I, Honda S-I, Inomata Y, Handa H, Omura T A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s J Biol Chem 1992, 267:17913-17919.
38. 17a) gene expression in bovine luteal cells in primary culture J Biol Chem 1991; 266.11170-11175.
39. Lauber ME, Waterman MR, Simpson ER Cyclic-AMP-dependent and tissue-specific expression of genes encoding steroidogenic enzymes in bovine luteal and granulosa cells in primary culture. Mol Cell Endocrinol 1993; 93-227-233.
40. Morris JK, Richards JS Luteinizing hormone (LH) induces prostaglandin endoperoxide synthase-2 (PGS-2) and luteinization in vitro by A-kinase and C-kinase pathways Endocrinology 1995; 136:1549-1558.
41. 2+ mobilization. J Biol Chem 1992; 267:4479-4488.
42. Meyer TE, Habener JF. Cyclic adenosine 3′,5′-monophosphate response element binding protein (CREB) and related transcription-activating deoxynucleic acid-binding proteins. Endocr Rev 1993; 14:268-290.
43. Gonzalez GA, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 1989, 59:675-680.
44. scc) gene. J Biol Chem 1990, 265-22392-22401
45. Rice DA, Kirkman MS, Aitken LD, Mouw, Schimmer BP, Parker KL. Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme. J Biol Chem 1990; 265:11713-11720.
46. Morohashi K, Zanger UM, Honda S, Hara M, Waterman Mu, Omura T. Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP. Mol Endocrinol 1993, 7.1196-1204.
47. Kwok RPS, Lundblad JB, Chrivia JC, Richards JP, Bachinger HP, Breiman RG, Roberts SGE, Green MR, Goodman RH Nuclear protein CBP is a coactivator for the transcription factor CREB Nature 1994; 370.223-226.
48. Anas J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Narure 1994, 370:226-229.
49. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 1993; 268 14553-14556.
50. Kyriakis JM, Brautigan DL, Ingebritsen TS, Avruch J. pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity. J Biol Chem 1991; 266:10043-10046
51. Derijard B, Hibi M, Wu I-H, Barrett T, Su B, Deng T, Karin M, Davis RJ JNK1: a protein kinase stimulated by UV light and HaRas that binds and phosphorylates the c-jun activation domain. Cell 1994; 76.1025-1037
52. Hershman HR. Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem 1991; 60:281-319.
53. Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T, Akira S. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci USA 1993, 90 2207-2211.
54. Shuai K, Stark GE, Kerr IM, Darnell JE Jr A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 1993; 261-1744-1746
55. Ruff-Jamison S, Chen K, Cohen S Induction by EGF and interferon-γ of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Science 1993; 261-1733-1736
56. Sadowski HB, Shuai K, Darnell E Jr, Gilman MZ A common nuclear signal transduction pathway activated by growth factor and cytokine receptor Science 1993; 261:1739-1744.
57. scc) mRNA in rat ovarian follicles and corpora lutea. Endocrinology 1987; 1201942-1950.