A genome-wide scan for loci affecting normal adult height in the Framingham Heart Study

Human Heredity

Volumn 55, Issue 4, 2003, Pages 191-201

  Mukhopadhyay, Nandita ^a   Finegold, David N ^a   Larson, Martin G ^b   Cupples, L Adrienne ^c   Myers, Richard H ^d   Weeks, Daniel E ^a,e  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

^c BOSTON UNIVERSITY   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Gene mapping; Human stature; Linkage analysis; Variance components

Indexed keywords

ADULT; ARTICLE; CHROMOSOME 9; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC VARIABILITY; GENOME; HUMAN; MALE; PEDIGREE; PHENOTYPE;

ADOLESCENT; ADULT; AGED; BODY HEIGHT; CARDIOVASCULAR DISEASES; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN; COHORT STUDIES; FEMALE; GENOME, HUMAN; GENOTYPE; HUMANS; LINKAGE (GENETICS); LOD SCORE; LONGITUDINAL STUDIES; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PEDIGREE; PHENOTYPE; QUANTITATIVE TRAIT LOCI; VARIATION (GENETICS);

EID: 0142218909     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000073203     Document Type: Article

References (38)

1. Pearson K, Lee A: On the laws of inheritance in man. I. Inheritance of physical characters. Biometrika 1903;2:357-462.
2. Roberts DF, Billewicz WZ, McGregor IA: Heritability of stature in a West African population. Ann Hum Genet 1978;42:15-24.
3. Solomon PJ, Thompson EA, Rissanen A: The inheritance of height in a Finnish population. Ann Hum Biol 1983;10:247-256.
4. Furusho T: On the manifestation of genotypes responsible for stature. Hum Biol 1968;40:437-455.
5. Kaur DP, Singh R: Parent-adult offspring correlations and heritability of body measurements in a rural Indian population. Ann Hum Biol 1981;8:333-339.
6. Tanksley SD: Mapping polygenes. Annu Rev Genet 1993;27:205-253.
7. Mackay TF: The genetic architecture of quantitative traits. Annu Rev Genet 2001;35:303-339.
8. Bost B, de Vienne D, Hospital F, Moreau L, Dillmann C: Genetic and nongenetic bases for the L-shaped distribution of quantitative trait loci effects. Genetics 2001;157:1773-1787.
9. Ginsburg E, Livshits G, Yakovenko K, Kobyliansky E: Major gene control of human body height, weight and BMI in five ethnically different populations. Ann Hum Genet 1998;62:307-322.
10. Minamitani K, Takahashi Y, Minagawa M, Yasuda T, Niimi H: Difference in height associated with a translation start site polymorphism in the vitamin D receptor gene. Pediatr Res 1998;44:628-632.
11. Arinami T, Iijima Y, Yamakawa-Kobayashi K, Ishiguro H, Ohtsuki T, Yanagi H, Shimakura Y, Ishikawa H, Hamaguchi H: Supportive evidence for contribution of the dopamine D2 receptor gene to heritability of stature: Linkage and association studies. Ann Hum Genet 1999;63:147-151.
12. Binder G, Schwarze CP, Ranke MB: Identification of short stature caused by SHOX defects and therapeutic effect of recombinant human growth hormone. J Clin Endocrinol Metab 2000;85:245-249.
13. Hasegawa Y, Fujii K, Yamada M, Igarashi Y, Tachibana K, Tanaka T, Onigata K, Nishi Y, Kato S, Hasegawa T: Identification of novel human GH-1 gene polymorphisms that are associated with growth hormone secretion and height. J Clin Endocrinol Metab 2000;85:1290-1295.
14. Thompson DB, Ossowski V, Janssen RC, Knowler WC, Bogardus C: Linkage between stature and a region on chromosome 20 and analysis of a candidate gene, bone morphogenetic protein 2. Am J Med Genet 1995;59:495-500.
15. Hirschhorn JN, Lindgren CM, Daly MJ, Kirby A, Schaffner SF, Burtt NP, Altshuler D, Parker A, Rioux JD, Platko J, Gaudet D, Hudson TJ, Groop LC, Lander ES: Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet 2001;69:106-116.
16. Perola M, Ohman M, Hiekkalinna T, Leppavuori J, Pajukanta P, Wessman M, Koskenvuo M, Palotie A, Lange K, Kaprio J, Peltonen L: Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups. Am J Hum Genet 2001;69:117-123.
17. Wiltshire S, Frayling TM, Hattersley AT, Hitman GA, Walker M, Levy JC, O'Rahilly S, Groves CJ, Menzel S, Cardon LR, McCarthy MI: Evidence for linkage of stature to chromosome 3p26 in a large U.K. family data set ascertained for type 2 diabetes. Am J Hum Genet 2002;70:543-546.
18. Xu J, Bleecker ER, Jongepier H, Howard TD, Koppelman GH, Postma DS, Meyers DA: Major recessive gene(s) with considerable residual polygenic effect regulating adult height: Confirmation of genomewide scan results for chromosomes 6, 9, and 12. Am J Hum Genet 2002;71:646-650.
19. Deng HW, Xu FH, Liu YZ, Shen H, Deng H, Huang QY, Liu YJ, Conway T, Li JL, Davies KM, Recker RR: A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of stature. Am J Med Genet 2002;113:29-39.
20. Wu X, Cooper RS, Boerwinkle E, Turner ST, Hunt S, Myers R, Olshen RA, Curb D, Zhu X, Kan D, Luke A: Combined analysis of genome-wide scans for adult height: Results from the NHLBI Family Blood Pressure Program. Eur J Hum Genet 2003;11:271-274.
21. Mukhopadhyay N, Finegold DN, Larson M, Cupples LA, Myers RH, Ferrell R, Weeks DE: Heritability of height and assortative mating in the Framingham Study. Am J Hum Genet 2000;67(suppl 2):235.
22. Mukhopadhyay N, Finegold DN, Larson M, Cupples LA, Myers RH, Ferrell R, Weeks DE: Genome-wide scan for loci affecting normal adult height in the Framingham Study. Am J Hum Genet 2001;69(suppl):402.
23. Kannel WB, Feinleib M, McNamara PM, Garrison RJ, Castelli WP: An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol 1979;110:281-290.
24. Dawber TR, Meadors GF, Moore FE Jr.: Epidemiological approaches to heart disease: The Framingham Study. Am J Public Health 1951;41:279-286.
25. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-1211.
26. Lange K, Weeks D, Boehnke M: Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol 1988;5:471-472.
27. Elston RC, Statistical Analysis for Genetics Epidemiology, Release 4.0 (http://darwin. cwru.edu/pub/sage.html). 2001, Computer program package from the Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Metro-Health Campus, Case Western Reserve University, Cleveland.
28. Hinds D, Risch N: The ASPEX package: Affected sib-pair mapping. ftp://lahmed.stanford.edu/pub/aspex. 1996;
29. McPeek MS, Sun L: Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 2000; 66:1076-1094.
30. Abecasis GR, Cherny SS, Cookson WO, Cardon LR: Merlin - Rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002;30:97-101.
31. Nagylaki T: The correlation between relatives with assortative mating. Ann Hum Genet 1978;42:131-137.
32. Sobel E, Sengul H, Weeks DE: Multipoint estimation of IBD probabilities at arbitrary positions among marker loci on general pedigrees. Hum Hered 2001;52:121-131.
33. Sobel E, Lange K: Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 1996;58:1323-1337.
34. Heath SC: Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet 1997;61:748-760.
35. Atwood LD, Heard-Costa NL, Cupples LA, Jaquish CE, Wilson PW, D'Agostino RB: Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am J Hum Genet 2002;71:1044-1050.
36. Cordell HJ: Sample size requirements to control for stochastic variation in magnitude and location of allele-sharing linkage statistics in affected sibling pairs. Ann Hum Genet 2001;65:491-502.
37. Hsueh WC, Goring HH, Blangero J, Mitchell BD: Replication of linkage to quantitative trait loci: Variation in location and magnitude of the lod score. Genet Epidemiol 2001;21:S473-478.
38. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS: Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet 1999;65:876-884.