Structure-oriented rational design of chymotrypsin inhibitor models

Protein Engineering

Volumn 16, Issue 9, 2003, Pages 673-681

  Mucsi, Zoltán ^a   Gáspári, Zoltán ^a   Orosz, György ^a,b   Perczel, András ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b CF Pharma Ltd   (Hungary)

Author keywords

Molecular modelling and dynamics; NMR spectroscopy; Peptide design; Protease inhibition; Structure activity relationship

Indexed keywords

CHYMOTRYPSIN INHIBITOR;

ARTICLE; CATTLE; MOLECULAR DYNAMICS; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BOS TAURUS; BOVINAE; SCHISTOCERCA; SCHISTOCERCA GREGARIA;

EID: 0142153202     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/gzg090     Document Type: Article

References (43)

1. Andreu, D., Albericio, F., Solé, N.A., Munson, M.C., Ferrer, M. and Barany, G. (1994) In Pennington, M.W. and Dunn, B.M. (eds), Formation of Disulfide Bonds in Synthetic Peptides and Proteins. Methods in Molecular Biology, Vol. 35: Peptide Synthesis Protocols. Humana Press, Totowa, NJ, pp. 91-168.
2. Antal, J., Pál, G., Bence, A., Buzás, Z., Patthy, A. and Gráf, L. (2001) Anal. Biochem., 288, 156-167.
3. Ardelt, W. and Laskowski, M. (1991) J. Mol. Biol., 220, 1041-1053.
4. Arico-Muendel, C.C., Patera, A., Pochapsky, T.C., Kuti, M. and Wolfson, A.J. (1999) Protein Eng., 12, 189-202.
5. Atherton, E. and Sheppard, R.C. (1989) In Rickwood, D. and Hannes, B.D. (eds), Solid Phase Peptide Synthesis: a Practical Approach. Oxford University Press, Oxford.
6. Bieth, J.G. (1995) Methods Enzymol., 248, 59-84.
7. Bode, W. and Huber, R. (1991) Eur. J. Biochem., 204, 433-451.
8. Bode, W. and Huber, R. (2000) Biochim. Biophys Acta, 1477, 241-252.
9. Boigegrain, R.A., Mattras, H., Brehélin, M., Paroutaud, P. and Coletti-Previero, M.A. (1992) Biochem. Biophys. Res. Commun., 189, 790-793.
10. Cai, M., Gong, X-Y., Wen, L. and Krishnamoorthi, R. (2002) Biochemistry, 41, 9572-9579.
11. Dittmann, K.H., Gueven, N., Mayer, K. and Rodemann, H.-P. (2001) Protein Eng., 14, 157-160.
12. Dixon, M. (1972) Biochem. J., 129, 197-202.
13. Gáspári, Z., Patthy, A., Gráf, L. and Perczel, A. (2002) Eur. J. Biochem. 269, 527-537.
14. Hamdaoui, A., Wataleb, S., Devreese, B., Chiou, S.J., Broeck, J.V., VanBeeumen, J., DeLoof, A. and Schoofs, L. (1998) FEBS Lett., 422, 74.
15. Klaus, W., Broger, C., Gerber, P. and Senn, H. (1993) J. Mol. Biol., 232, 897-906.
16. Koradi, R., Billeter, M. and Wüthrich, K. (1996) J. Mol. Graph., 14, 51-55.
17. Kraulis, P.J. (1991) J. Appl. Crystallogr., 24, 946-950.
18. Laskowski, M. and Qasim, M.A., (2000) Biochim. Biophys Acta, 1477, 324-337.
19. Leatherbarrow R.J. (1987) Enzfitter, a Program for Non-linear Regression Analysis. Elsevier, Amsterdam.
20. Li, A. and Daggett, V. (1995) Protein Eng., 8, 1117.
21. Lindahl, E., Hess, B. and van der Spoel, D. (2001) J. Mol. Model., 7, 306-317.
22. Liu, J., Prakash, O., Cai, M., Gong, Y., Huang, Y., Wen, L., Wen, J.J., Huang, J.-K. and Krishnamoorthi, R. (1996) Biochemistry, 35, 1516-1524.
23. Liu, J., Gong, Y., Prakash, O., Wen, L., Lee, L., Huang, J.-K. and Krishnamoorthi, R. (1998) Protein Sci., 7, 132-141.
24. Malik, Z. et al. (1999) Biochim. Biophys. Acta, 1434, 143-150.
25. Mer, G., Kellenberger, C., Koehl, P., Stote, R., Sorokine, O., Van Dorsselaer, A., Luu, B., Hietter, H. and Lefèvre, J.-F. (1994) Biochemistry, 33, 15397-15407.
26. Mer, G., Hietter, H., Kellenberger, C., Renatus, M., Luu, B. and Lefèvre, J.-F. (1996a) J. Mol. Biol., 258, 158.
27. Mer, G., Hietter, H. and Lefèvre, J.-F. (1996b) Nat. Struct. Biol., 3, 45-53.
28. Mer, G., Dejaegere, A., Stote, R., Kiefer, B. and Lefèvre, J.-F. (1996c) J. Phys. Chem., 100, 2667-2674.
29. Mucsi, Z., Perczel, A. and Orosz, G. (2002) J. Pept. Sci., 8, 643-655.
30. Nilges, M., Clore, G.M. and Gronenborn, A.M. (1988) FEBS Lett., 239, 129.
31. Nilges, M., Kuszewski, J. and Brünger, A.T. (1991) In Hoch, J.C. (ed.), Computational Aspects of the Study of Biological Macromolecules by NMR. Plenum Press, New York.
32. Prevelige, P., Jr and Fasman, G.D. (1989) In Fasman, G.D. (ed.), Prediction of Protein Structure and the Principles of Protein Conformation. Plenum Press, New York.
33. Ravichandran, S., Dasgupta, J., Chakrabati, C., Ghosh, S., Singh, M. and Dattagupta, J.K. (2001) Protein Eng., 4, 349-357.
34. Redfield, C. (1993) In Roberts, G.C.K. (ed.), NMR of Macromolecules. Oxford University Press, Oxford, pp. 71-99.
35. Riniker, B., Flörsheimer, A., Fretz, H., Sieber, P. and Kamber, B. (1993) Tetrahedron, 41, 9307-9320.
36. Roussel, A., Mathieu, M., Dobbs, A., Luu, B., Cambillau, C. and Kellenberger, C. (2001) J. Biol. Chem., 276, 38893-38898.
37. Schechter, I. and Berger, A. (1967) Biochem. Biophys. Res. Commun., 27, 157-162.
38. Schellenberger, V., Braune, K., Hoffman, M.-J. and Jakube, H.-D. (1991) Eur. J. Biochem., 199, 7339-7347.
39. Shaw, G.L., Davis, B., Keeler, J. and Fersht, A.R. (1995) Biochemistry, 34, 2225-2233.
40. Simonet, G., Claeys, I. and Vanden Broeck, J. (2002) Comp. Biochem. Physiol. Biochem. Mol. Biol., 132, 247-255.
41. Terada, S., Sato, K., Kato, T. and Izumiya, N. (1980) Int. J. Pept. Protein Res. 15, 441-454.
42. Tripos (2001) SYBYL Molecular Modelling Package, Version 6.6. and 6.7. Tripos, St. Louis, MO.
43. Wolfson, A.J., Kanaoka, M., Lau, F.T. and Ringe, D. (1991) Protein Eng., 4, 313-317.