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Volumn 8, Issue 5, 1998, Pages 652-658

Neural substrates of Drosophila rhythms revealed by mutants and molecular manipulations

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIOR; BRAIN CELL; CELL MUTANT; CIRCADIAN RHYTHM; DROSOPHILA; EMBRYO DEVELOPMENT; GENE EXPRESSION; MOLECULAR GENETICS; NERVE TRACT; NEUROCHEMISTRY; NONHUMAN; PACEMAKER NERVE CELL; PRIORITY JOURNAL; REVIEW;

EID: 0032192419     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80095-0     Document Type: Article
Times cited : (62)

References (75)
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    • of special interest. Surprisingly, this paper is the first to document the expression pattern of per in larval CNS. The study revealed novel properties of clock gene regulation, such as differences in the spatial expression patterns of the per and tim genes, as well as cycling of PER and TIM in one neuronal cluster that occurs in antiphase to such rpotein oscillations in other clusters. In subsets of the neurons (LNs) that express these two genes, cyclical PER expression persists from the first instar larvae onward. This sugests that they are involved in the 'larval time memory', which can be tapped into to control the phase of periodic adult-emergence or of rhythmic fly behavior, several days after a larva is given a clock-resetting light stimulus (cf. [48-50]).
    • of special interest Kaneko M, Helfrich-Förster C, Hall JC. Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock-gene product cycling. J Neurosci. 17:1997;6745-6760 Surprisingly, this paper is the first to document the expression pattern of per in larval CNS. The study revealed novel properties of clock gene regulation, such as differences in the spatial expression patterns of the per and tim genes, as well as cycling of PER and TIM in one neuronal cluster that occurs in antiphase to such rpotein oscillations in other clusters. In subsets of the neurons (LNs) that express these two genes, cyclical PER expression persists from the first instar larvae onward. This sugests that they are involved in the 'larval time memory', which can be tapped into to control the phase of periodic adult-emergence or of rhythmic fly behavior, several days after a larva is given a clock-resetting light stimulus (cf. [48-50]).
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    • Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
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    • of special interest. Three per - lacZ fusion gene constructs were compared with respect to the manner in which they can control temporal and spatial expression patterns within the CNS and peripheral nervous system, as well as behavioral circadian rhythms. Different elements within PER were found to be responsible for molecular oscillations and behavior function. This report also provides good documentation of these widely applied reporter - gene constructs, especially in terms of per - lacZ fusion genes that mediate β-galactosidase (β-gal) cycling and others that do not (owing to too little PER being present for instability, leading to very slow β - gal turnover).
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.