Caffeine reduces hypnotic effects of alcohol through adenosine A 2A receptor blockade

Neuropharmacology

Volumn 45, Issue 7, 2003, Pages 977-985

  El Yacoubi, M ^a   Ledent, C ^b   Parmentier, M ^b   Costentin, J ^a   Vaugeois, J M ^a  

^a UFR de Médecine and Pharmacie   (France)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Adenosine A2A receptor; Caffeine; Ethanol; Knockout; Mice; SCH 58261, DPCPX, Righting reflex

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR BLOCKING AGENT; ALCOHOL; CAFFEINE; DIPYRIDAMOLE; PENTOBARBITAL;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; COMA; CONTROLLED STUDY; DRUG OVERDOSE; DRUG SELECTIVITY; EXTRACELLULAR SPACE; HYPNOSIS; KNOCKOUT MOUSE; LIGHT DARK CYCLE; MALE; MOUSE; NARCOLEPSY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECTUM TEMPERATURE; RIGHTING REFLEX; WILD TYPE;

EID: 0142122418     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00254-5     Document Type: Article

References (51)

1. Allan A.M., Harris R.A. Sensitivity to ethanol hypnosis and modulation of chloride channels does not cosegregate with pentobarbital sensitivity in HS mice. Alcoholism: Clinical and Experimental Research. 13:1989;428-434.
2. Anderson R., Sheehan M.J., Strong P. Characterization of the adenosine receptors mediating hypothermia in the conscious mouse. British Journal of Pharmacology. 113:1994;1386-1390.
3. Ballarin M., Fredholm B.B., Ambrosio S., Mahy N. Extracellular levels of adenosine and its metabolites in the striatum of awake rats: inhibition of uptake and metabolism. Acta Physiologica Scandinavica. 142:1991;97-103.
4. Baumgold J., Nikodijevic O., Jacobson K.A. Penetration of adenosine antagonists into mouse brain as determined by ex vivo binding. Biochemical Pharmacology. 43:1992;889-894.
5. Crawley J.N., Patel J., Marangos P.J. Adenosine uptake inhibitors potentiate the sedative effects of adenosine. Neuroscience Letters. 36:1983;169-174.
6. Crews F.T., Morrow A.L., Criswell H., Breese G. Effects of ethanol on ion channels. International Review of Neurobiology. 39:1996;283-367.
7. Daly J.W., Butts-Lamb P., Padjett W. Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines. Cellular and Molecular Neurobiology. 3:1983;69-80.
8. Dar M.S. Brain adenosinergic modulation of acute ethanol-induced motor impairment. Alcohol and Alcoholism Supplement. 2:1993;425-429.
9. Dar M.S. Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor. Brain Research Bulletin. 55:2001;513-520.
10. Dar M.S., Mustafa S.J., Wooles W.R. Possible role of adenosine in the CNS effects of ethanol. Life Sciences. 33:1983;1363-1374.
11. Dar M.S., Jones M., Close G., Mustafa S.J., Wooles W.R. Behavioral interactions of ethanol and methylxanthines. Psychopharmacology. 91:1987;1-4.
12. Diamond I., Gordon A.S. Cellular and molecular neuroscience of alcoholism. Physiological Reviews. 77:1997;1-19.
13. Dunwiddie T.V. The physiological role of adenosine in the central nervous system. International Review of Neurobiology. 27:1985;63-139.
14. Dunwiddie T.V., Worth T. Sedative and anticonvulsant effects of adenosine analogs in mouse and rat. The Journal of Pharmacology and Experimental Therapeutics. 220:1982;70-76.
15. El Yacoubi M., Ledent C., Parmentier M., Daoust M., Costentin J., Vaugeois J.-M. Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice. Neuropharmacology. 40:2001;424-432.
16. 2A receptor blockade. European Neuropsychopharmacology. 12:(Suppl. 3):2002;S401. (Abstract P5.041).
17. Fenu S., Pinna A., Ongini E., Morelli M. Adenosine A2A receptor antagonism potentiates L-DOPA-induced turning behaviour and c-fos expression in 6-hydroxydopamine-lesioned rats. European Journal of Pharmacology. 321:1997;143-147.
18. Finn D.A., Syapin P.J., Bejanian M., Jones B.L., Alkana R.L. Temperature dependence of ethanol depression in mice: dose response. Alcoholism: Clinical and Experimental Research. 18:1994;382-386.
19. Fredholm B.B. Are methylxanthine's effects due to antagonism of endogenous adenosine? Trends in Pharmacological Sciences. 1:1980;129-132.
20. Fredholm B.B. Adenosine, adenosine receptors and the actions of caffeine. Pharmacology and Toxicology. 76:1995;93-101.
21. Fredholm B.B., Bättig K., Holmén J., Nehlig A., Zvartau E.E. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews. 51:1999;83-133.
22. Glowa J.R., Crawley J., Suzdak P.D., Paul S.M. Ethanol and the GABA receptor complex: studies with the partial inverse benzodiazepine receptor agonist Ro 15-4513. Pharmacology Biochemistry and Behavior. 31:1988;767-772.
23. Hasenfratz M., Bunge A., Dal Pra G., Battig K. Antagonistic effects of caffeine and alcohol on mental performance parameters. Pharmacology Biochemistry and Behavior. 46:1993;463-465.
24. Hobbs W.R., Rall T.W., Verdoorn T.A. Hypnotics and sedatives; ethanol. Hardman J.G., Goodman Gilman A., Limbird L.E., Molinoff P.B., Ruddon R.W. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 1996;361-396 McGraw-Hill, New York.
25. Jacobson K.A., van Rhee M. Development of selective purinoceptor agonists and antagonists. Jacobson K.A., Jarvis M.F. Purinergic Approaches in Experimental Therapeutics. 1997;101-128 Wiley-Liss, New York.
26. Kaputlu I., Sadan G., Ozdem S. Exogenous adenosine potentiates hypnosis induced by intravenous anaesthetics. Anaesthesia. 53:1998;496-500.
27. Kiss A., Farah K., Kim J., Garriock R.J., Drysdale T.A., Hammond J.R. Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain. Biochemical Journal. 352:2000;363-372.
28. Krauss S.W., Ghirnikar R.B., Diamond I., Gordon A.S. Inhibition of adenosine uptake by ethanol is specific for one class of nucleoside transporters. Molecular Pharmacology. 44:1993;1021-1026.
29. Ledent C., Vaugeois J.-M., Schiffmann S.N., Pedrazzini T., El Yacoubi M., Vanderhaeghen J.J., Costentin J., Heath J.K., Vassart G., Parmentier M. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature. 388:1997;674-678.
30. Marston H.M., Finlayson K., Maemoto T., Olverman H.J., Akahane A., Sharkey J., Butcher S.P. Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques. The Journal of Pharmacology and Experimental Therapeutics. 285:1998;1023-1030.
31. Martz A., Deitrich R.A., Harris R.A. Behavioral evidence for the involvement of gamma-aminobutyric acid in the actions of ethanol. European Journal of Pharmacology. 89:1983;53-62.
32. Mehta A.K., Ticku M.K. An update on GABAA receptors. Brain Research Reviews. 29:1999;196-217.
33. Monopoli A., Lozza G., Forlani A., Mattavelli A., Ongini E. Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats. Neuroreport. 9:1998;3955-3959.
34. Mustafa S.J. Effects of coronary vasodilator drugs on the uptake and release of adenosine in cardiac cells. Biochemical Pharmacology. 28:1979;2617-2624.
35. 2A receptors. The Journal of Neuroscience. 22:2002;10487-10493.
36. O'Connor M.F., Howerton T.C., Collins A.C. Effects of pentobarbital in mice selected for differential sensitivity to ethanol. Pharmacology Biochemistry and Behavior. 17:1982;245-248.
37. Olah M.E., Stiles G.L. The role of receptor structure in determining adenosine receptor activity. Pharmacology & Therapeutics. 85:2000;55-75.
38. Ongini E., Dionisotti S., Gessi S., Irenius E., Fredholm B.B. Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 359:1999;7-10.
39. Porkka-Heiskanen T., Strecker R.E., Thakkar M., Bjorkum A.A., Greene R.W., McCarley R.W. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science. 276:1997;1265-1268.
40. Radulovacki M., Virus R.M., Djuricic-Nedelson M., Green R.D. Adenosine analogs and sleep in rats. The Journal of Pharmacology and Experimental Therapeutics. 228:1984;268-274.
41. Randall C.L., Lester D. Differential effects of ethanol and pentobarbital on sleep time in C57BL and BALB mice. The Journal of Pharmacology and Experimental Therapeutics. 188:1974;27-33.
42. Satoh S., Matsumura H., Suzuki F., Hayaishi O. Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. Proceedings of the National Academy of Sciences of the United States of America. 93:1996;5980-5984.
43. Snyder S.H., Katims J.J., Annau Z., Bruns R.F., Daly J.W. Adenosine receptors and behavioral actions of methylxanthines. Proceedings of the National Academy of Sciences of the United States of America. 78:1981;3260-3264.
44. Suzdak P.D., Glowa J.R., Crawley J.N., Schwartz R.D., Skolnick P., Paul S.M. A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science. 234:1986;1243-1247.
45. Svenningsson P., Nomikos G.G., Ongini E., Fredholm B.B. Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens. Neuroscience. 79:1997;753-764.
46. Svenningsson P., Le Moine C., Fisone G., Fredholm B.B. Distribution, biochemistry and function of striatal adenosine A2A receptors. Progress in Neurobiology. 59:1999;355-396.
47. Syapin P.J., Gee K.W., Alkana R.L. Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia. Brain Research Bulletin. 19:1987;603-605.
48. Tanase D., Baghdoyan H.A., Lydic R. Dialysis delivery of an adenosine A1 receptor agonist to the pontine reticular formation decreases acetylcholine release and increases anesthesia recovery time. Anesthesiology. 98:2003;912-920.
49. Ticku M.K. Alcohol and GABA-benzodiazepine receptor function. Annals of Medicine. 22:1990;241-246.
50. Yanik G., Glaum S., Radulovacki M. The dose-response effects of caffeine on sleep in rats. Brain Research. 403:1987;177-180.
51. Zocchi C., Ongini E., Conti A., Monopoli A., Negretti A., Baraldi P.G., Dionisotti S. The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist. The Journal of Pharmacology and Experimental Therapeutics. 276:1996;398-404.