Molecular genetics of carbapenem antibiotic biosynthesis

Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

Volumn 75, Issue 1-2, 1999, Pages 135-141

  McGowan, Simon J ^a   Holden, Matthew T G ^b   Bycroft, Barrie W ^b   Salmond, George P C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

lactam antibiotic; Carbapenem; Erwinia carotovora; Quorum sensing; Serratia marcescens; Thienamycin

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; BETA LACTAM ANTIBIOTIC; CARBAPENEM; LACTONE DERIVATIVE;

ANTIBIOTIC BIOSYNTHESIS; ANTIBIOTIC RESISTANCE; ARTICLE; CHROMOSOME; ENTEROBACTERIACEAE; GENE CLUSTER; MOLECULAR GENETICS; NONHUMAN; PECTOBACTERIUM CAROTOVORUM; PRIORITY JOURNAL; SERRATIA MARCESCENS; SIGNAL TRANSDUCTION; STREPTOMYCETACEAE;

CARBAPENEMS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; PECTOBACTERIUM CAROTOVORUM; SERRATIA MARCESCENS;

BACTERIA (MICROORGANISMS); ERWINIA; NEGIBACTERIA; PECTOBACTERIUM CAROTOVORUM; POSIBACTERIA; PROKARYOTA; SERRATIA; SERRATIA MARCESCENS; STREPTOMYCES; STREPTOMYCETACEAE;

EID: 0033020290     PISSN: 00036072     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1001768428383     Document Type: Article

References (39)

1. Ahmer BMM, Van Reeuwijk J, Timmers CD, Valentine PJ & Heffron F (1998) Salmonella typhimurium encodes an SdiA homolog, a putative quorum sensor of the LuxR family, that regulates genes on the virulence plasmid. J. Bact. 180: 1185-1193
2. Albers-Schonberg G, Arison BH, Hensens OD, Hirshfield J, Hoogsteen K, Kaczka EA, Rhodes RE, Kahan JS, Kahan FM, Ratcliffe RW, Walton E. Ruswinkle LJ, Morin RB & Christensen BG (1978) Structure and absolute configuration of thienamycin. J. Am. Chem. Soc. 100: 6491-6499
3. Baggaley KH, Brown AG & Schofield CJ (1997) Chemistry and biosynthesis of clavulanic acid and other clavams. Nat. Prod. Rep. 14: 309-333
4. Bainton NJ, Stead P, Chhabra SR, Bycroft BW, Salmond GPC, Stewart GSAB & Williams P (1992a) N-(3-oxohexanoyl)-L-homoserine lactone regulates carbapenem antibiotic production in Erwinia carotovora. Biochem. J. 288: 997-1004
5. Bainton NJ, Bycroft BW, Chhabra SR, Stead P, Gledhill L, Hill PJ, Rees CED, Winson MK, Salmond GPC, Stewart GSAB & Williams P (1992b) A general role for the lux autoinducer in bacterial cell signalling: control of antibiotic biosynthesis in Erwinia. Gene 116: 87-91
6. Brown AG, Butterworth D, Cole M, Hanscomb G, Hood JD & Reading C (1976) Naturally-occurring β-lactamase inhibitors with antibacterial activity. J. Antibiotics29: 668-669
7. Bycroft BW, Maslen C, Box SJ, Brown A & Tyler JW (1988) The biosynthetic implications of acetate and glutamate incorporation into (3R,5R)-carbapenam-3-carboxylic acid and (5R)-carbapen-2-em-3-carboxylic acid by Serratia sp. J. Antibiotics 41: 1231-1242
8. Chhabra SR, Stead P, Bainton NJ, Salmond, GPC, Stewart, GSAB, Williams, P and Bycroft, BW (1993) Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactone. J. Antibiotics. 46: 441-454
9. Coulton, S & Hunt, E (1996) Recent advances in the chemistry and biology of carbapenem antibiotics. Prog. Med. Chem. 33: 99-145
10. Cox, ARJ, Thomson, NR, Bycroft, BW, Stewart, GSAB, Williams, P & Salmond, GPC (1998) A pheromone-independent CarR protein controls carbapenem antibiotic synthesis in the opportunistic human pathogen Serratia marcescens. Microbiol. 144: 201-209
11. Distler, J, Ebert, A, Mansouri, K, Pissowotski, K, Stockman, M & Piepersberg, W (1987) Gene cluster for streptomycin biosynthesis in Streptomyces griseus - nucleotide sequence of three genes and analysis of transcriptional activity. Nuc. Acids Res. 15: 8041-8056
12. Elson, SW, Baggaley, KH, Fulston, M, Nicholson, NH, Tyler, JW, Edwards, J, Holms, H, Hamilton, I & Mousdale, DM (1993a) Two novel arginine derivatives from a mutant of Streptomyces clavuligerus. J. Chem. Soc. Chem. Comm. 15: 1211-1212
13. Elson, SW, Baggaley, KH, Davison, M, Fulston, M, Nicholson, NH, Risbridger, GD & Tyler, JW (1993b) The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway. J. Chem. Soc. Chem. Comm. 15: 1212-1214
14. Fuqua, WC, Winans, SC & Greenberg, EP (1994) Quorum sensing in bacteria - the LuxR-LuxI family of cell density-responsive transcriptional regulators. J. Bact. 176: 269-275
15. Fuqua, WC, Winans, SC & Greenberg, EP (1996) Census and consensus in bacterial ecosystems - the LuxR-LuxI family of quorum-sensing transcriptional regulators. Ann. Rev. Microbiol. 50: 727-751
16. Hodgson, JE, Fosberry, AP, Rawlinson, NS, Ross, HNM, Neal, RJ, Arnell, JC, Earl, AJ & Lawlor, EJ (1995) Clavulanic acid biosynthesis in Streptomyces clavuligerus - gene cloning and characterisation. Gene 166: 49-55
17. Holden, MTG, McGowan, SJ, Bycroft, BW, Stewart, GSAB, Williams, P & Salmond, GPC (1998) Cryptic carbapenem antibiotic production genes are widespread in Erwinia carotovora: facile trans activation by the carR transcriptional regulator. Microbiol. 144: 1495-1508
18. Jones, S, Yu,B, Bainton, NJ, Birdsall, M, Bycroft, BW, Chhabra, SR, Cox, AJR, Golby, P, Reeves, PJ, Stephens, S, Winson, MK, Salmond, GPC, Stewart, GSAB & Williams, P (1993) The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa EMBO. J. 12: 2477-2482
19. Kahan, FM, Kropp, H, Sundelof, JG & Birnbaum, J (1983) Thienamycin: development of imipenem-cilastatin. J. Antimicrob. Chemother. 12:D1-D35
20. Kintaka, K, Harada, S, Ono, H & Okazaki, H (1985) Production of a carbapenem antibiotic by a spiral bacterium, Azospirillum sp. J. Takeda Res. Lab. 44: 17-21
21. Kropp, H, Sundelof, JG, Kahah, JS, Kahan, FM & Birnbaum, J (1980) MK0787 (N-formimidoyl thienamycin): Evaluation of in vitro and in vivo activities. Antimicrob. Agents Chemother. 17: 993-1000
22. Li, R, Wang, Y & Zeng, Y (1993) Cloning of the thienamycin biosynthetase genes from Streptomyces cattleya. Chin. J. Biotechnol. 9: 1-7
23. Libby, SJ, Goebel, W, Ludwig, A, Buchmeier, N, Bowe, N, Fang, FC, Guiney, DG, Songer, JG & Heffron, F (1994) A cytolysin encoded by Salmonella is required for survival within macrophages. Proc. Natl. Acad. Sci. 91: 489-493
24. McGowan, S, Sebaihia, M, Jones, S, Yu, B, Bainton, N, Chan, PF, Bycroft, B, Stewart, GSAB, Williams, P & Salmond, GPC (1995) Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional regulator. Microbiol. 141: 541-550
25. McGowan, SJ, Sebaihia, M, Porter, LE, Stewart, GSAB, Williams, P, Bycroft, BW & Salmond, GPC (1996) Analysis of bacterial carbapenem antibiotic production genes reveals a novel β-lactam biosynthesis pathway. Mol. Microbiol. 22: 415-426
26. McGowan, SJ, Sebaihia, M, O'Leary, S, Hardie, KR, Williams, P, Stewart, GSAB, Bycroft, BW & Salmond, GPC (1997) Analysis of the carbapenem gene cluster of Erwinia carotovora: definition of the antibiotic biosynthetic genes and evidence for a novel β-lactam resistance mechanism. Mol. Microbiol. 26: 545-556
27. McGowan, SJ, Bycroft, BW & Salmond, GPC (1998) Bacterial production of carbapenems and clavams: evolution of β-lactam antibiotic pathways. Trends Microbiol. 6: 203-208
28. Meighen, EA (1991) Molecular biology of bacterial bioluminescence. Microbiol. Rev. 55: 123-142
29. More, MI, Finger, LD, Stryker, JL, Fuqua, C, Eberhard, A & Winans, SC (1996) Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates. Science. 272: 1655-1658
30. Nakata, K, Horinouchi, S & Beppu, T (1989) Cloning and characterization of the carbapenem biosynthetic genes from Streptomyces fulvoviridis. FEMS Microbiol. Letts. 57: 51-56
31. Neu, HC (1994) Why carbapenems? Curr. Opin. Inf. Dis. 7: (suppl. 1) S3-S10
32. Parker, WL, Rathnum, ML, Wells, JS, Trejo, WH, Principe, PA & Sykes, RB (1982) SQ27860, a simple carbapenem produced by species of Serratia and Erwinia. J. Antibiotics 35: 653-660
33. Robson, ND, Cox, ARJ, McGowan, SJ, Bycroft, BW & Salmond, GPC (1997) Bacterial N-acyl-homoserine-lactone-dependent signalling and its potential biotechnological applications. Trends Biotechnol. 15: 458-464
34. Salmond, GPC, Bycroft, BW, Stewart, GSAB & Williams, P (1995) The bacterial 'enigma': cracking the code of cell-cell communication. Mol. Microbiol. 16: 615-624
35. Schaefer, AL, Val, DL, Hanzelka, BL, Cronan, JE & Greenberg, EP (1996) Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischen LuxI protein. Proc. Natl. Acad. Sci. 93: 9505-9509
36. Swift, S, Winson, MK, Chan, PF, Bainton, NJ, Birdsall, M, Reeves, PJ, Rees, CED, Chhabra, SR, Hill, PJ, Throup, JP, Bycroft, BW, Salmond, GPC, Williams, P & Stewart, GSAB (1993) A novel strategy for the isolation of luxI homlogues: evidence for the widespread distribution of a luxR:luxI superfamily in enteric bacteria. Mol. Microbiol. 10: 511-520
37. Thomson, NR, Cox, A, Bycroft,B W, Stewart, GSAB, Williams, P & Salmond, GPC (1997) The Rap and Hor proteins of Erwinia, Serratia and Yersinia: a novel subgroup in a growing superfamily of proteins regulating diverse physiological processes in bacterial pathogens. Mol. Microbiol. 26: 531-544
38. Williams, P, Bainton, NJ, Swift, S, Chhabra, SR, Winson, MK, Stewart, GSAB, Salmond, GPC & Bycroft, BW (1992) Small molecule-mediated density-dependent control of gene expression in prokaryotes: bioluminescence and the biosynthesis of carbapenem antibiotics. FEMS Microbiol. Letts. 100: 161-168
39. Williamson, JM, Inamine, E, Wilson, KE, Douglas, AW, Liesch, JM & Albers-Schonberg, G (1985) Biosynthesis of the β-lactam antibiotic, thienamycin, by Streptomyces cattleya. J. Biol. Chem. 260: 4637-4647