메뉴 건너뛰기




Volumn 23, Issue 2 A, 2003, Pages 813-818

Farnesyltransferase inhibitors - A novel approach in the treatment of advanced pancreatic carcinomas

Author keywords

Clinical studies; Farnesyltransferase inhibitors; Pancreatic carcinoma; Ras oncogenes

Indexed keywords

3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ANTINEOPLASTIC AGENT; FLUOROURACIL; GEMCITABINE; L 778123; LONAFARNIB; PROTEIN; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TIPIFARNIB;

EID: 0038538402     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (19)

References (33)
  • 3
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancers: A review
    • Bos JL: Ras oncogenes in human cancers: a review. Cancer Res 49: 4682-4689, 1989.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 4
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
    • Rowinsky EK, Windle JJ and von Hoff DD: Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development. J Clin Oncol 17: 3631-3652, 1999.
    • (1999) J Clin Oncol , vol.17 , pp. 3631-3652
    • Rowinsky, E.K.1    Windle, J.J.2    Von Hoff, D.D.3
  • 6
    • 0025194466 scopus 로고
    • Inhibition of purified p21 ras farnesyl protein transferase by Cys-AAX tetrapeptides
    • Reiss Y, Goldstein JL, Seabra MC, Casely PJ and Brown MS: Inhibition of purified p21 ras farnesyl protein transferase by Cys-AAX tetrapeptides. Cell 62: 81-88, 1990.
    • (1990) Cell , vol.62 , pp. 81-88
    • Reiss, Y.1    Goldstein, J.L.2    Seabra, M.C.3    Casely, P.J.4    Brown, M.S.5
  • 7
    • 0033637047 scopus 로고    scopus 로고
    • Protein farnesyl transferase as a target for the development of anticancer drugs
    • Adjei AA: Protein farnesyl transferase as a target for the development of anticancer drugs. Drugs Fut 25: 1069-1079, 2000.
    • (2000) Drugs Fut , vol.25 , pp. 1069-1079
    • Adjei, A.A.1
  • 8
    • 0034730625 scopus 로고    scopus 로고
    • FTIs block the farnesylation of CENP-E and CENP-F, and alter the association of CENP-E with the microtubules
    • Ashar HR, James L and Gray K: FTIs block the farnesylation of CENP-E and CENP-F, and alter the association of CENP-E with the microtubules. J Biol Chem 275: 30451-30457, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 30451-30457
    • Ashar, H.R.1    James, L.2    Gray, K.3
  • 9
    • 0020132123 scopus 로고
    • Isolation of transforming sequence from a human bladder carcinoma cell line
    • Shih C and Weinberg RA: Isolation of transforming sequence from a human bladder carcinoma cell line. Cell 29: 161-169 (1982).
    • (1982) Cell , vol.29 , pp. 161-169
    • Shih, C.1    Weinberg, R.A.2
  • 10
    • 0027239613 scopus 로고
    • Function and regulation of ras
    • Lowy DR and Willumsen BM: Function and regulation of ras. Ann Rev Biochem 62: 851-891, 1993.
    • (1993) Ann Rev Biochem , vol.62 , pp. 851-891
    • Lowy, D.R.1    Willumsen, B.M.2
  • 11
    • 0027050783 scopus 로고
    • Biochemistry of protein prenylation
    • Casey PJ: Biochemistry of protein prenylation. J Lipid Res 33: 1731-1740, 1992.
    • (1992) J Lipid Res , vol.33 , pp. 1731-1740
    • Casey, P.J.1
  • 14
    • 0026611951 scopus 로고
    • p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein
    • Duronio V, Welham MJ, Abraham S, Dryden P and Schrader JW: p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein. Proc Natl Acad Sci USA 89: 1587-1591, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1587-1591
    • Duronio, V.1    Welham, M.J.2    Abraham, S.3    Dryden, P.4    Schrader, J.W.5
  • 15
    • 0026666233 scopus 로고
    • Farnesylcysteine, a constituent of the a and b subunits of the rabbit skeletal muscle phosphorylase kinase: Localization by conversion to S-ethylcysteine and by tandem mass spectrometry
    • Heilmeyer LM, Serwe M, Weber C, Metzger J, Hoffmann-Posorske E and Meyer HE: Farnesylcysteine, a constituent of the a and b subunits of the rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometry. Proc Natl Acad Sci USA 89: 9554-9558, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9554-9558
    • Heilmeyer, L.M.1    Serwe, M.2    Weber, C.3    Metzger, J.4    Hoffmann-Posorske, E.5    Meyer, H.E.6
  • 17
    • 0000144681 scopus 로고    scopus 로고
    • Phase I pharmacokinetic trial of the farnesyl transferase inhibitor SCH66366 plus gemcitabine in advanced cancers
    • Hurwitz HI, Amado R and Prager D: Phase I pharmacokinetic trial of the farnesyl transferase inhibitor SCH66366 plus gemcitabine in advanced cancers. Proc Am Soc Clin Oncol 19: 717, 2000.
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 717
    • Hurwitz, H.I.1    Amado, R.2    Prager, D.3
  • 19
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
    • Liu M, Bryant MS and Chen J: Antitumor activity of SCH66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res 58: 4947-4956, 1998.
    • (1998) Cancer Res , vol.58 , pp. 4947-4956
    • Liu, M.1    Bryant, M.S.2    Chen, J.3
  • 20
    • 0032539559 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothiones
    • Moasser MM, Sepp-Lorenzino L and Kohl NE: Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothiones. Proc Natl Acad Sci USA 95: 1369-1374, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1369-1374
    • Moasser, M.M.1    Sepp-Lorenzino, L.2    Kohl, N.E.3
  • 22
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
    • Rak J, Mitsuhhashi Y and Bayko L: Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 55: 4575-4580, 1995.
    • (1995) Cancer Res , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhhashi, Y.2    Bayko, L.3
  • 24
    • 0036131991 scopus 로고    scopus 로고
    • Overcoming drug resistance: Targeting more than one site
    • Karp JE and Mookerjee BP: Overcoming drug resistance: targeting more than one site. Leuk Res 1: 107-109, 2002.
    • (2002) Leuk Res , vol.1 , pp. 107-109
    • Karp, J.E.1    Mookerjee, B.P.2
  • 26
    • 0029921232 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor FTI-277 radiosensitizes H-ras transformed rat embryo fibroblasts
    • Bernhard EJ, Kao G and Cox AD: The farnesyl transferase inhibitor FTI-277 radiosensitizes H-ras transformed rat embryo fibroblasts. Cancer Res 56: 1727-1730, 1996.
    • (1996) Cancer Res , vol.56 , pp. 1727-1730
    • Bernhard, E.J.1    Kao, G.2    Cox, A.D.3
  • 27
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allee-specific oligonucleotide hybridization
    • Hruban RH, van Offerhaus GJ, Allison DC, Goodman SN, Kensler TW, Bose KK, Camerons JL and Bos JL: K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allee-specific oligonucleotide hybridization. Am J Pathol 143: 545-554, 1993.
    • (1993) Am J Pathol , vol.143 , pp. 545-554
    • Hruban, R.H.1    Van Offerhaus, G.J.2    Allison, D.C.3    Goodman, S.N.4    Kensler, T.W.5    Bose, K.K.6    Camerons, J.L.7    Bos, J.L.8
  • 28
    • 0028053024 scopus 로고
    • K-ras mutation in colorectal cancer: Relations to patient age, sex and tumour location
    • Breivik J, Meling GI, Spurkland A, Rognum TO and Gaudernack G: K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location. Br J Cancer 69: 367-371, 1994.
    • (1994) Br J Cancer , vol.69 , pp. 367-371
    • Breivik, J.1    Meling, G.I.2    Spurkland, A.3    Rognum, T.O.4    Gaudernack, G.5
  • 30
    • 0027425027 scopus 로고
    • p53 and-N-ras-mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive leukemia
    • Abo J, Inokuchi K, Dan K and Nomura T: p53 and-N-ras-mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive leukemia. Blood 82: 2829-2836, 1993.
    • (1993) Blood , vol.82 , pp. 2829-2836
    • Abo, J.1    Inokuchi, K.2    Dan, K.3    Nomura, T.4
  • 31
    • 0000375697 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of continuous daily oral SCH66336, a novel farnesyl transferase inhibitor, in patients with solid tumors
    • Eskens F, Awada A, Verweij J, Cutler DL, Hanauske A and Piccart M: Phase I and pharmacologic study of continuous daily oral SCH66336, a novel farnesyl transferase inhibitor, in patients with solid tumors. Proc Am Soc Clin Oncol 18: 600, 1999.
    • (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 600
    • Eskens, F.1    Awada, A.2    Verweij, J.3    Cutler, D.L.4    Hanauske, A.5    Piccart, M.6
  • 32
    • 0000097049 scopus 로고    scopus 로고
    • The farnesyl protein transferase (FPTase) inhibitor L-778123 in patients with solid cancers
    • Britten CD, Rowinsky E and Yao SL: The farnesyl protein transferase (FPTase) inhibitor L-778123 in patients with solid cancers. Proc Am Soc Clin Oncol 18: 155A, 1999.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Britten, C.D.1    Rowinsky, E.2    Yao, S.L.3
  • 33
    • 0000441628 scopus 로고    scopus 로고
    • Phase I clinical trial with the farnesyltransferase inhibitor BMS 214662 in patients with advanced solid tumors
    • Ryan DP, Eder JP and Supko JG: Phase I clinical trial with the farnesyltransferase inhibitor BMS 214662 in patients with advanced solid tumors. Proc Am Soc Clin Oncol 19: 720, 2000.
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 720
    • Ryan, D.P.1    Eder, J.P.2    Supko, J.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.