Cytokeratin 20 and guanylyl cyclase C mRNA is largely present in lymph node and liver specimens of colorectal cancer patients

International Journal of Cancer

Volumn 107, Issue 4, 2003, Pages 617-628

  Conzelmann, Michael ^a   Dieterle, Christoph P ^a   Linnemann, Ulrich ^b   Berger, Martin R ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Municipal Hospital Nurnberg Nord   (Germany)

Author keywords

Disseminated tumor cells (DTC); Hematogenic and lymphatic spread; RT PCR detection of epithelial markers

Indexed keywords

CYTOKERATIN 20; GUANYLATE CYCLASE; GUANYLYL CYCLASE C; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BONE MARROW METASTASIS; CANCER CLASSIFICATION; CANCER INCIDENCE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DISEASE MARKER; FEMALE; HEMATOPOIETIC CELL; HUMAN; HUMAN TISSUE; LIVER FUNCTION; LIVER METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PROTEIN LOCALIZATION; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL;

AGED; BONE MARROW; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANYLATE CYCLASE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; KERATIN-20; LIVER; LYMPH NODES; LYMPHATIC METASTASIS; MALE; NEOPLASM CIRCULATING CELLS; NEOPLASM STAGING; PROSPECTIVE STUDIES; RECEPTORS, PEPTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TUMOR MARKERS, BIOLOGICAL;

EID: 0142053906     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11425     Document Type: Article

References (45)

1. Midgley R, Kerr D. Colorectal cancer. Lancet 1999;353:391-9.
2. American Joint Committee on Cancer. Manual of staging for cancer, 4th ed. Philadelphia: Lippincott, 1992, 75-82.
3. Deans GT, Parks TG, Rowlands BJ, Spence RAJ. Prognostic factors in colorectal cancer. Br J Surg 1992;79:608-13.
4. Molnar B, Ladanyi A, Tanko L, Sréter L, Tulassay Z. Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients. Clin Cancer Res 2001;7:4080-5.
5. Leinung S, Würl P, Schönfelder A, Weiss C, Röder I, Schönfelder M. Detection of cytokeratin-positive cells in bone marrow in breast cancer and colorectal carcinoma in comparison with other prognostic factors of prognosis. J Hematother Stem Cell Res 2000;9:905-11.
6. Juhl H, Stritzel M, Wroblewski A, Henne-Bruns D, Kremer B, Schmiegel W, Neumaier M, Wagener C, Schreiber HW, Kalthoff H. Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients. Int J Cancer 1994;57:330-5.
7. Cutait R, Alves VAF, Lopes LC, Cutait DE, Borges JLA, Singer J, da Silva JH, Groffi FS. Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratins. Dis Colon Rectum 1991;34:917-20.
8. Dimmler A, Gerhards R, Betz C, Günther K, Reingruber B, Horbach T, Baumann I, Kirchner T, Hohenberger W, Papadopoulos T. Transcription of cytokeratins 8, 18, and 19 in bone marrow and limited expression of cytokeratins 7 and 20 by carcinoma cells: inherent limitations for RT-PCR in the detection of isolated tumor cells. Lab Invest 2001;81:1351-61.
9. Gunn J, McCall JL, Yun K, Wright PA. Detection of micrometastases in colorectal cancer patients by k19 and k20 reverse-transcription polymerase chain reaction. Lab Invest 1996;75:611-6.
10. Carrithers SL, Parkinson SJ, Scott BS, Goldstein SD, Park PK, Urbanski RW, Waldman SA. Escherichia coli heat-stable enterotoxin receptors. Dis Colon Rectum 1996;39:171-81.
11. Cagir B, Gelmann A, Park J, Fava T, Tenkelevitch A, Bittner EW, Weaver EJ, Palazzo JP, Weinberg D, Fry RD, Waldman SA. Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer. Ann Intern Med 1999;131:805-12.
12. Liefers GJ, Cleton-Jansen AM, Van de Velde CJH, Hermans J, Van Krieken HJM, Cornelisse CJ, Tollenaar RA. Micrometastases and survival in stage II colorectal cancer. N Engl J Med 1998;339:223-8.
13. Hayashi N, Ito I, Yanagisawa A, Kato Y, Nakamori S, Imaoka S, Watanabe H, Ogawa M, Nakamura Y. Genetic diagnosis of lymphnode metastasis in colorectal cancer. Lancet 1995;345:1257-9.
14. Schimanski CC, Linnemann U, Berger MR. Sensitive detection of k-ras mutations augments diagnosis of colorectal cancer metastases in the liver. Cancer Res 1999;59:5169-75.
15. Hardingham JE, Hewett PJ, Sage RE, Finch JL, Nutall JD, Kotasek D, Dobrovic A. Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease. Int J Cancer 2000;89:8-13.
16. Weitz J, Kienle P, Lacroix J, Willeke F, Benner A, Lehnert T, Herfarth C, von Knebel Doeberitz M. Dissemination of tumor cells in patients undergoing surgery for colorectal cancer. Clin Cancer Res 1998;4:343-8.
17. Koch M, Weitz J, Kienle P, Benner A, Willeke F, Lehnert T, Heffarth C, von Knebel Doeberitz M. Comparative analysis of tumor cell dissemination in mesenteric, central, and peripheral venous blood in patients with colorectal cancer. Arch Surg 2001;136:85-9.
18. Weitz J, Kienle P, Magener A, Koch M, Schroedel A, Willeke F, Autschbach F, Lacroix J, Lehnert T, Herfarth C, von Knebel Doeberitz M. Detection of disseminated tumor cells in lymph nodes, blood and bone marrow. Clin Cancer Res 1999;5:1830-6.
19. Moll R, Löwe A, Laufer J, Franke WW. Cytokeratin 20 in human carcinomas. Am J Pathol 1992;140:427-47.
20. Carrithers SL, Barber MT, Biswas S, Parkinson SJ, Park PK, Goldstein SD, Waldman SA. Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissue. Proc Natl Acad Sci USA 1996;93:14827-32.
21. Tot T. Adenocarcinomas metastatic to the liver: the value of cytokeratins 20 and 7 in the search for unknown primary tumors. Cancer 1999;85:171-7.
22. Tan J, Hytiroglou P, Wiezorek R, Park Y, Thung S, Arias B, Theise ND. Immunohistochemical evidence for hepatic progenitor cells in liver diseases. Liver 2002;22:365-73.
23. Jung R, Krueger W, Hosch S, Holweg M, Kroeger N, Gutensohn K, Wagener C, Neumaier M, Zander AR. Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro. Br J Cancer 1998;78:1194-8.
24. Pearlman J, Prawer S, Barber M, Parkinson S, Schulz S, Park J, Zook M, Waldman SA. A splice variant of the transcript for guanylyl cyclase C is expressed in human colon and colorectal cancer cells. Dig Dis Sci 2000;45:298-305.
25. Wigmore S, Madhavan K, Redhead D, Currie E, Garden O. Distribution of colorectal liver metastases in patients referred for hepatic resection. Cancer 2000;89:285-7.
26. Ratto C, Sofo L, Ippoliti M, Merico M, Doglietto G, Crucitti F. Prognostic factors in colorectal cancer. Dis Colon Rectum 1998;41:1033-49.
27. Burchill S, Bradbury M, Pittman K, Southgate J, Smith B, Selby P. Detection of epithelial cancer cells in peripheral blood by reverse transcriptase-polymerase chain reaction. Br J Cancer 1995;71:278-81.
28. Waldmann S, Cagir B, Rakinic J, Fry R, Goldstein S, Isenberg G, Barber M, Biswas S, Minimo C, Palazzo J, Park PK, Weinberg D. Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer. Br J Cancer 1998;41:310-5.
29. Bustin S, Gyselman V, Williams N, Dorudi S. Detection of cytokeratins 19/20 and guanylyl cyclase C in peripheral blood of colorectal cancer patients. Br J Cancer 1999;79:1813-20.
30. Jung R, Petersen K, Krueger W, Wolf M, Wagener C, Zander A, Neumaier M. Detection of micrometastasis by cytokeratin 20 RT-PCR is limited due to stable background transcription in granulocytes. Br J Cancer 1999;81:870-3.
31. Vlems F, Diepstra J, Cornelissen I, Ruers T, Ligtenberg M, Punt C, van Krieken JH, Wobbes T, van Muijen GN. Limitations of cytokeratin 20 RT-PCR to detect disseminated tumor cells in blood and bone marrow of patients with colorectal cancer: expression in controls and downregulation in tumor tissue. J Clin Pathol 2002;55:156-63.
32. Futamura M, Takagi Y, Koumura H, Kida H, Tanemura H, Shimokawa K, Saji S. Spread of colorectal cancer micrometastases in regional lymph nodes by reverse transcriptase-polymerase chain reactions for carcinoembryonic antigen and cytokeratin 20. J Surg Oncol 1998;68:34-40.
33. Rosenberg R, Hoos A, Mueller J, Nekarda H. Impact of cytokeratin 20 and carcinoembryonic antigen mRNA detection by RT-PCR in regional lymph nodes of patients with colorectal cancer. Br J Cancer 2000;83:1323-9.
34. Yamaguchi K, Takagi Y, Aoki S, Futamura M, Saji S. Significant detection of circulating cancer cells in the blood by reverse-transcriptase-polymerase chain reaction during colorectal cancer resection. Annals Surg 2000;232:58-65.
35. Funaki N, Tanaka J, Ohshio G, Onodera H, Maentani S, Imamura M. Cytokeratin 20 mRNA in peripheral venous blood of colorectal carcinoma patients. Br J Cancer 1998;77:1327-32.
36. Nakamori S, Kameyama M, Furukawa H, Takeda O, Sugai S, Imaoka S, Nakamura Y. Genetic detection of colorectal cancer cells in circulation and lymph nodes. Dis Colon Rectum 1997;40(Suppl):29-36.
37. Soeth E, Roeder C, Juhl H, Krueger U, Kremer B, Kalthoff H. The detection of disseminated tumor cells in bone marrow from colorectal cancer patients by a cytokeratin-20-specific nested reverse- transcriptase-polymerase-chain reaction is related to the stage of the disease. Int J Cancer 1996;69:278-82.
38. Denis M, Lipart C, LeBorgne J, LeHur P, Galmiche J, Denis M, Ruud E, Truchaud A, Lustenberger P. Detection of disseminated tumor cells in peripheral blood of colorectal cancer patients. Int J Cancer 1997;74:540-4.
39. Fujita S, Kudo N, Takayuki A, Moriya Y. Detection of cytokeratin 19 and 20 mRNA in peripheral blood from colorectal cancer patients and their prognosis. Int J Colorectal Dis 2001;16:141-6.
40. Wyld D, Selby P, Perren T, Jonas S, Allen-Mersh T, Wheeldon J, Burchill SA. Detection of colorectal cancer cells in peripheral blood by reverse-transcriptase polymerase chain reaction for cytokeratin 20. Int J Cancer 1998;79:288-93.
41. Oeberg A, Stenling R, Tavelin B, Lindmark G. Are lymph node micrometastases of any clinical significance in Dukes stages A and B colorectal cancer? Dis Colon Rectum 1998;41:1244-9.
42. Rosenberg R, Hoos A, Mueller J, Baier P, Stricker D, Werner M, Nekarda H, Siewert JR. Prognostic significance of cytokeratin 20 reverse transcriptase polymerase chain reaction in lymph nodes of node-negative colorectal cancer patients. J Clin Oncol 2002;20:1049-55.
43. Raj R, Moreno J, Gomella L. Utilization of polymerase chain reaction technology in the detection of solid tumors. Cancer 1999;82:1419-42.
44. Barbera-Guillem E, Smith I, Weiss L. Cancer-cell traffic in the liver. Growth kinetics of cancer cells after portal-vein delivery. Int J Cancer 1992;52:974-7.
45. Topal B, Penninckx F, Yap S. Colorectal cancer cells in the liver: from micro- to macrometastatic disease. Acta Chir Belg 2000;100:7-11.