Cutting edge: Effector memory CD8+ T cells in the lung airways retain the potential to mediate recall responses

Journal of Immunology

Volumn 171, Issue 7, 2003, Pages 3338-3342

  Ely, Kenneth H ^a   Roberts, Alan D ^a   Woodland, David L ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ADOPTIVE TRANSFER; AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; INFECTION CONTROL; LUNG LAVAGE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; LYMPHOID TISSUE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENDAI VIRUS; VIRUS INFECTION; VIRUS REPLICATION;

EID: 0142031446     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.7.3338     Document Type: Article

References (22)

1. + T-cell memory determined by clonal burst size. Nature 369:652.
2. + T cells in primary and secondary influenza pneumonia. Immunity 8:683.
3. Lukacher, A. E., V. L. Braciale, and T. J. Braciale. 1984. In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J. Exp. Med. 160:814.
4. Ostler, T., T. Hussell, C. D. Surh, P. Openshaw, and S. Ehl. 2001. Long-term persistence and reactivation of T cell memory in the lung of mice infecred with respiratory syncytial virus. Eur. J. Immunol. 31:2574.
5. + T cells persist in the lungs following recovery from respiratory virus infections. J. Immunol. 166:1813.
6. Liang, S., K. Mozdzanowska, G. Palladino, and W. Gerhard. 1994. Heterosubtypic immunity to influenza type A virus in mice: effector mechanisms and their longevity. J. Immunol. 152:1653.
7. + T cells that persist in the lungs. J. Exp. Med. 193:981.
8. + T cells to the lung airways during respiratory virus infections. J. Immunol. 170:1423.
9. Harris, N. L., V. Watt, F. Ronchese, and G. Le Gros. 2002. Differential T cell function and fare in lymph node and nonlymphoid tissues. J. Exp. Med. 1-95:317.
10. Lefrancois, L. 2002. Dual personality of memory T cells. Trends Immunol. 23:226.
11. Altman, J. D., P. H. Moss, P. R. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94.
12. Thatte, J., V. Dabak, M. B. Williams, T. J. Braciale, and K. Ley. 2003. LFA-1 is required for retention of effector CD8 T cells in mouse lungs. Blood 101:4916.
13. + cells. J. Exp. Med. 195:1523.
14. + T cells. J. Exp. Med. 196:935.
15. Becker, T. C., E. J. Wherry, D. Boone, K. Murali-Krishna, R. Antia, A. Ma, and R. Ahmed. 2002. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J. Exp. Med. 195:1541.
16. Perera, L. P., C. K. Goldman, and T. A. Waldmann. 1999. IL-15 induces the expression of chemokines and their receptors in T lymphocytes. J. Immunol. 162:2606.
17. Schluns, K. S., K. Williams, A. Ma, X. X. Zheng, and L. Lefrancois. 2002. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J. Immunol. 168:4827.
18. Wherry, E. J., T. C. Becker, D. Boone, M. K. Kaja, A. Ma, and R. Ahmed. 2002. Homeostatic proliferation but nor the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Rα. Adv. Exp. Med. Biol. 512:165.
19. Borron, P. J., E. C. Crouch, J. F. Lewis, J. R. Wright, F. Possmayer, and L. J. Fraher. 1998. Recombinant rat surfactanr-associated protein D inhibits human T lymphocyte proliferation and IL-2 production. J. Immunol. 161:4599.
20. Kremlev, S. G., T. M. Umstead, and D. S. Phelps. 1994. Effects of surfactant protein A and surfactant lipids on lymphocyte proliferation in vitro. Am. J. Physiol. 267:L357.
21. Wilsher, M. L., D. A. Hughes, and P. L. Haslam. 1988. Immunoregulatory properties of pulmonary surfactant: effect of lung lining fluid on proliferation of human blood lymphocytes. Thorax 43:354.
22. Yao, L. J., L. J. Fraher, R. A. Veldhuizen, S. Samuelson, P. Borron, J. Malloy, L. McCaig, and J. F. Lewis. 2001. Effects of alveolar surfactant aggregates on T-lymphocyte proliferation. Biochim. Biophys. Acta 1535:266.