Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 10, 2003, Pages 3275-3280

  Quenelle, Debra C ^a   Collins, Deborah J ^a   Kern, Earl R ^a,b  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CIDOFOVIR; CYTOSINE; DRUG DERIVATIVE; ORGANOPHOSPHORUS COMPOUND;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; CERCOPITHECUS; CONTROLLED STUDY; COWPOX; COWPOX VIRUS; DISEASE MODEL; DRUG ADMINISTRATION; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; GROWTH, DEVELOPMENT AND AGING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; POXVIRUS INFECTION; PRIORITY JOURNAL; SCID MOUSE; SMALLPOX; TIME OF DEATH; VACCINIA; VACCINIA VIRUS; VERO CELL; VIROLOGY; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; COWPOX; COWPOX VIRUS; CYTOSINE; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, VIRAL; FEMALE; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; VACCINIA; VERO CELLS;

EID: 0141994005     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.10.3275-3280.2003     Document Type: Article

References (27)

1. Boyle, J. J., R. F. Haff, and R. C. Stewart. 1966. Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice. Antimicrob. Agents Chemother. 6:536-539.
2. Bray, M., M. Martinez, D. F. Smee, D. Kefauver, E. Thompson, and J. W. Huggins. 2000. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge. J. Infect. Dis. 181:10-19.
3. Bray, M., M. Martinez, D. Kefauver, M. West, and C. Roy. 2002. Treatment of aerosolized cowpox virus infection in mice with aerosolized cidofovir. Antivir. Res. 54:129-142.
4. Breman, J., and D. A. Henderson. 1998. Poxvirus dilemmas-monkeypox, smallpox and biological terrorism. N. Engl. J. Med. 339:556-559.
5. Buller, R. M. L. 1985. The BALB/c mouse as a model to study orthopoxviruses. Curr. Top. Microbiol. Immunol. 122:148-153.
6. De Clercq, E. 2001. Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections. Clin. Microbiol. Rev. 14:382-397.
7. De Clercq, E., and P. De Somer. 1968. Effect of interferon, polyacrylic acid, and polymethacrylic acid on tail lesions in mice infected with vaccinia virus. Appl, Microbiol. 16:1314-1319.
8. De Clercq, E., A. Holy, and I. Rosenberg. 1989. Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo. Antimicrob. Agents Chemother. 33:185-191.
9. De Clercq, E., M. Luczak, D. Shugar, P. F. Torrence, J. A. Waters, and B. Witkop. 1976. Effect of cytosine arabinoside, iododeoxyuridine, ethyldeoxyuridine, thiocyanatodeoxyuridine, and ribavirin on tail lesion formation in mice infected with vaccinia virus. Proc. Soc. Exp. Biol. Med. 151:487-490.
10. Dewan, P. K., A. M. Fry, K. Laserson, B. C. Tierney, C. P. Quinn, J. A. Hayslett, L. N. Broyles, A. Shane, K. L. Winthrop, I. Walks, L. Siegel, T. Hales, V. A. Semenova, S. Romero-Steiner, C. Elie, R. Khabbaz, A. S. Khan, R. A. Hajjeh, and A. Schuchat. 2002. Inhalational anthrax outbreak among postal workers, Washington, D.C., 2001. Emerg. Infect. Dis. 10:1066-1072.
11. Heymann, D. L., M. Szczeniowski, and K. Esteves. 1988. Re-emergence of monkeypox in Africa: a review of the past six years. Br. Med. Bull. 54:693-702.
12. Jacobson, M. A., S. Wilson, H. Stanley, C. Holtzer, J. Cherrington, and S. Safrin. 1999. Phase I study of combination therapy with intravenous cidofovir and oral gangciclovir for cytomegalovirus retinitis in patients with AIDS. Clin. Infect. Dis. 28:528-533.
13. Kern, E. R., C. Hartline, E. Harden, K. Keith, N. Rodriguez, J. R. Beadle, and K. Y. Hostetler. 2002. Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir. Antimicrob. Agents Chemother. 46:991-995.
14. LeDuc, J. W., I. Damon, D. A. Relman, J. Huggins, and P. B. Jahrling. 2002. Smallpox research activities: U.S. interagency collaboration, 2001. Emerg. Infect. Dis. 8:743-745.
15. LeDuc, J. W., and P. B. Jahrling. 2001. Strengthening national preparedness for smallpox: an update. Emerg. Infect. Dis. 7:155-157.
16. Martinez, M. J., M. P. Bray, and J. W. Huggins. 2000. A mouse model of aerosol-transmitted orthopoxviral disease. Arch. Pathol. Lab. Med. 124:362-377.
17. Miller, C. G., D. E. Justus, S. Jayaraman, and G. J. Kotwal. 1995. Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis. Cell. Immunol. 162:326-332.
18. Miller, C. G., S. N. Shchelkunov, and G. J. Kotwal. 1997. The cowpox virus-encoded homolog of the vaccinia virus complement control protein is an inflammation modulatory protein. Virology 229:126-133.
19. Mims, C. A. 1968. The response of mice to the intravenous injection of cowpox virus. Br. J. Exp. Pathol. 49:24-32.
20. Neyts, J., and E. De Clercq. 2001. Efficacy of 2-amino-7-(1, 3-dihydroxy-2-propoxymethyl)purine for treatment of vaccinia virus (orthopoxvirus) infections in mice. Antimicrob. Agents Chemother. 45:84-87.
21. Neyts, J., and E. De Clercq. 1993. Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice. J. Med. Virol. 41:242-246.
22. Rybak, R. J., J. Zemlika, Y. Qiu, C. B. Hartline, and E. R. Kern. 1999. Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides. Antivir. Res. 43:175-188.
23. Smee, D. F., K. W. Bailey, and R. W. Sidwell. 2001. Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir. Antivir. Chem. Chemother. 12:71-76.
24. Smee, D. F., K. W. Bailey, and R. W. Sidwell. 2000. Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir. Antivir. Chem. Chemother. 11:303-309.
25. Smee, D. F., K. W. Bailey, M. H. Wong, and R. W. Sidwell. 2000. Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir. Antivir. Res. 47:171-177.
26. Smee, D. F., K. W. Bailey, M. H. Wong, and R. W. Sidwell. 2001. Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice. Antivir. Res. 52:55-62.
27. Wehrle, P. F., P. J. Posch, K. H. Richter, and D. A. Henderson. 1970. An airborne outbreak of smallpox in a German hospital and its significance with respect to recent outbreaks in Europe. Bull. W. H. O. 43:669-679.