A rapid assay for the brevetoxin group of sodium channel activators based on fluorescence monitoring of synaptoneurosomal membrane potential

Toxicon

Volumn 42, Issue 2, 2003, Pages 191-198

  David, Laurence S ^a   Plakas, Steven M ^b   El Said, Kathleen R ^b   Jester, Edward L E ^b   Dickey, Robert W ^b   Nicholson, Russell A ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Brevetoxins; Membrane potential; Mouse brain synaptoneurosomes; NSP toxin assay; Rhodamine 6G; Voltage sensitive sodium channels

Indexed keywords

BREVETOXIN; VERATRIDINE; FLUORESCENT DYE; MARINE TOXIN; OXOCIN DERIVATIVE; PTYCHODISCUS BREVIS T2 TOXIN; RHODAMINE; RHODAMINE 6G; SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; CYTOTOXICITY; DEPOLARIZATION; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; MUSSEL; NONHUMAN; OYSTER; PRIORITY JOURNAL; SPIKE; SYNAPTIC POTENTIAL; ANIMAL; BIVALVE; CELL MEMBRANE POTENTIAL; CHEMISTRY; DINOFLAGELLATE; DRUG EFFECT; DRUG POTENTIATION; FLUORESCENCE; METABOLISM; MOUSE STRAIN; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; SYNAPTOSOME; TIME;

OSTREIDAE;

ANIMALS; BIVALVIA; DINOFLAGELLIDA; FLUORESCENCE; FLUORESCENT DYES; MALE; MARINE TOXINS; MEMBRANE POTENTIALS; MICE; MICE, INBRED STRAINS; OSTREIDAE; OXOCINS; REFERENCE VALUES; RHODAMINES; SENSITIVITY AND SPECIFICITY; SODIUM CHANNELS; SYNAPTOSOMES; TIME FACTORS; VERATRIDINE;

EID: 0141975288     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(03)00133-8     Document Type: Article

References (42)

1. 2-(5). J. Neurochem. 48:1987;522-559.
2. Atchison N.D., Luke V.S., Narahashi T., Vogel S.M. Nerve membrane sodium channels as the target site of brevetoxins at neuromuscular junctions. Br. J. Pharmacol. 89:1986;731-738.
3. Auchi T., Daimatsu T., Nakaya K., Nakamura Y. Fluorescence changes of rhodamine 6G associated with changes in membrane potential in synaptosomes. Biochim. Biophys. Acta. 685:1982;289-296.
4. Aune T. Health effects associated with algal toxins from seafood. Arch. Toxicol. Suppl. 19:1997;389-397.
5. Baden D.G. Brevetoxins: unique polyether dinoflagellate toxins. FASEB J. 3:1989;1807-1817.
6. Borison H.E., McCarthy L.E., Ellis S. Neurological analysis of respiratory, cardiovascular and neuromuscular effects of brevetoxin in cats. Toxicon. 23:1985;517-524.
7. Catterall W.A., Risk M. Toxin T46 from Ptychodiscus brevis (formerly Gymnodinium breve) enhances activation of voltage-sensitive sodium channels by veratridine. Mol. Pharmacol. 19:1980;345-348.
8. Cattet M., Geraci J.R. Distribution and elimination of ingested brevetoxin (PbTx-3) in rats. Toxicon. 31:1993;1483-1486.
9. Dickey R., Jester E., Granade R., Mowdy D., Moncrieff C., Rebarchik D., Robl M., Musser S., Poli M. Monitoring brevetoxins during a Gymnodinium breve Red Tide: comparison of sodium channel-specific cytotoxicity assay and mouse bioassay for determination of neurotoxic shellfish toxins in shellfish extracts. Nat. Toxins. 7:1999;157-165.
10. Dortch Q., Moncrieff C.A., Mendenhall W.M., Parsons M.L., Franks J.S., Hemphill K.W. Spread of Gymnodinium breve into the northern Gulf of Mexico. Regeura B., Blanco J., Fernandez M.L., Wyatt T. VIII International Conference on Harmful Marine Algae. 1998;143-144 Xunta de Galicia and IOC of UNESCO, Vigo, Spain.
11. Ellis S. Introduction to symposium - Brevetoxins: chemistry, and pharmacology of 'red tide' toxins from Ptychodiscus brevis (formerly Gymnodinium breve). Toxicon. 23:1985;469-472.
12. Geesey M., Tester P.A. Gymnodinium breve: ubiquitous in Gulf of Mexico waters? Smayda T.J., Shimizu Y. Toxic phytoplankton blooms in the sea. 1993;251-255 Elsevier, New York.
13. Harris R.A., Allen A.M. Functional coupling of γ-aminobutyric acid receptors to chloride channels in brain membranes. Science. 228:1985;1100-1108.
14. Huang J.M.C., Wu C.H. Pharmacological actions of brevetoxin from Ptychodiscus brevis on nerve membranes. Oikachi T., Anderson D.M., Nemoto T. Red Tides, Environmental Science and Toxicology. 1989;379-386 Elsevier, New York.
15. Hughes J.M. Epidemiology of shellfish poisoning in the United States, 1971-1977. Taylor D.L., Seliger H.H. Toxic Dinoflagellate Blooms. 1979;23-28 Elsevier/North Holland, New York.
16. 1, a polyether marine toxin from the New Zealand shellfish, Austrovenus stutchburyi. Tetrahedron Lett. 36:1995;725-728.
17. Jeglitsch G., Rein K., Baden D.G., Adams D.J. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons. J. Pharmacol. Exp. Ther. 284:1998;516-525.
18. Koley J., Sinha S., Basak A.K., Das M., Dube S.N., Majumder P.K., Gupta A.K., Dasgupta S., Koley B. Cardiovascular and respiratory changes following exposure to a synthetic toxin of Ptychodiscus brevis. Eur. J. Pharmacol. 293:1995;483-486.
19. + channel. FEBS Lett. 219:1987;355-359.
20. Manger R.L., Leja L.S., Lee S.Y., Hungerford J.M., Hokama Y., Dickey R.W., Granade R.H., Lewis R., Yasumoto T., Wekell M. Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts. J. AOAC Int. 78:1995;521-527.
21. McFarren E.F., Tanabe H., Silva F.J., Wilson W.B., Campbell J.E., Lewis K.H. The occurrence of a ciguatera-like poison in oysters, clams and Gymnodinium breve cultures. Toxicon. 3:1965;111-123.
22. Morris P.D. Clinical and epidemiological features of neurotoxic shellfish poisoning in North Carolina. Am. J. Public Health. 81:1991;471-474.
23. Music S.I., Howell J.T., Brumback C.L. Red tide, its public health implications. J. Fla. Med. Ass. 60:1973;27-29.
24. Nicholson R.A., Li G.H., Buenaventura E., Graham D. A rapid and sensitive assay for paralytic shellfish poison (PSP) toxins using mouse brain synaptoneurosomes. Toxicon. 40:2002;831-838.
25. Parmentier J.L., Narahashi T., Wilson W.A., Trieff N.M., Ramanujam V.M.S., Risk M., Ray S.M. Electrophysiological and biochemical characteristics of Gymnodinium breve toxins. Toxicon. 16:1978;235-244.
26. Peterson G.L., et al. A simplification of the protein assay of Lowry et al. which is more generally applicable. Anal. Biochem. 83:1977;346-356.
27. Pierce R.H. Red tide (Ptychodiscus brevis) toxin aerosols: a review. Toxicon. 24:1986;955-965.
28. Plakas S.M., El Said K.R., Jester E.L.E., Granade H.R., Musser S.M., Dickey R.W. Confirmation of brevetoxin metabolism in the Eastern oyster (Crassostrea virginica) by controlled exposures to pure toxins and to Karenia brevis cultures. Toxicon. 40:2002;721-729.
29. Poli M.A., Mende T.J., Baden D.G. Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes. Mol. Pharmacol. 30:1986;129-135.
30. Poli M.A., Templeton C.B., Pace J., Hines H.B. Detection, metabolism and pathophysiology of brevetoxins. Hall S., Strichartz G. ACS Symposium Series 418. ACS Symposium Series 418. 1990;176-191 American Chemical Society, Washington, DC.
31. Poli M.A., Rein K.S., Baden D.G. Radioimmunoassay for PbTx-2-type brevetoxins: epitope specificity of two anti-PbTx sera. J. AOAC Int. 78:1995;538-542.
32. Risk M., Norris P.J., Coutinho-Netto J., Bradford H.F. Actions of Ptychodiscus brevis Red Tide toxin on metabolic and transmitter-releasing properties of synaptosomes. J. Neurochem. 39:1982;1485-1488.
33. Sharkey R.G., Jover E., Couraud F., Baden D.G., Catterall W.A. Allosteric modulation of neurotoxin binding to voltage-sensitive sodium channels by Gymnodinium breve toxin 2. Mol. Pharmacol. 31:1987;273-278.
34. Steidinger K.A., Baden D.G. Toxic marine minoflagellates. Spector D.L. Dinoflagellates. 1984;201-261 Academic Press, New York.
35. Recommended Procedures for the Examination of Sea Water and Shellfish. fourth ed Recommended Procedures for the Examination of Sea Water and Shellfish. 1970;The American Public Health Association, Washington, DC. pp. 61-66.
36. Templeton C.B., Poli M.A., LeClaire R.D. Cardiorespiratory effects of brevetoxin (PbTx-2) in conscious tethered rats. Toxicon. 27:1989;1043-1049.
37. Templeton C.B., Poli M.A., Solow R. Prophylactic and therapeutic use of an antibrevetoxin (PbTx-2) antibody in conscious rats. Toxicon. 27:1989;1389-1395.
38. Trainer V.L., Baden D.G. An enzyme immunoassay for the detection of Florida red tide brevetoxins. Toxicon. 29:1991;1387-1394.
39. Trainer V.L., Poli M.A. In: Animal Toxins: Facts and Protocols (Methods and Tools in Biosciences and Medicine). 2000.
40. Trainer V.L., Thomsen W.J., Catterall W.A., Baden D.G. Photoaffinity labelling of the brevetoxin receptor on sodium channels in rat brain synaptosomes. Mol. Pharmacol. 40:1991;988-994.
41. Van Dolah F.M., Finley E.L., Haynes B.L., Doucette G.J., Moeller P.D., Ramsdell J.S. Development of rapid and sensitive high throughput pharmacologic assays for marine phycotoxins. Nat. Toxins. 2:1994;189-196.
42. A receptors and voltage-gated sodium channels in vitro: a putative ligand for depressant drug sites in CNS. Br. J. Pharmacol. 129:2000;283-290.