Confirmation of brevetoxin metabolism in the Eastern oyster (Crassostrea virginica) by controlled exposures to pure toxins and to Karenia brevis cultures

Toxicon

Volumn 40, Issue 6, 2002, Pages 721-729

  Plakas, Steven M ^a   El Said, Kathleen R ^a   Jester, Edward L E ^a   Ray Granade, H ^a   Musser, Steven M ^a   Dickey, Robert W ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Brevetoxin; Brevetoxin metabolism; Cytotoxicity; Eastern oyster; Karenia brevis; Liquid chromatography mass spectrometry

Indexed keywords

BREVETOXIN; CYSTEINE BREVETOXIN CONJUGATE; MARINE TOXIN; SULFOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRASSOSTREA VIRGINICA; KARENIA BREVIS; METABOLISM; NEUROTOXICITY; NONHUMAN; OYSTER; PRIORITY JOURNAL; RED TIDE; SHELLFISH;

ANIMALS; BRAIN NEOPLASMS; CELL SURVIVAL; CHROMATOGRAPHY, LIQUID; DINOFLAGELLIDA; DOSE-RESPONSE RELATIONSHIP, DRUG; MARINE TOXINS; MICE; NEUROBLASTOMA; OSTREIDAE; OXOCINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TUMOR CELLS, CULTURED;

ANIMALIA; CRASSOSTREA; CRASSOSTREA VIRGINICA; KARENIA; KARENIA BREVIS; OSTREIDAE;

EID: 0036236297     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00267-7     Document Type: Article

References (11)

1. Brevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neurons
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3. Spread of Gymnodinium breve into the northern Gulf of Mexico
4. The relationship of brevetoxin length and A-ring functionality to binding and activity in neuronal sodium channels
5. Depolarizing action of a red tide dinoflagellate brevetoxin on axonal membranes
6. Brevetoxin B1, a new polyether marine toxin from the New Zealand shellfish Austrovenus stutchburyi
7. Study on neurotoxic shellfish poisoning involving the oyster, Crassostrea gigas, in New Zealand
8. Brevetoxin B3, a new brevetoxin analog isolated from the greenshell mussel Perna canaliculus involved in neurotoxic shellfish poisoning in New Zealand
9. Brevetoxin B4 isolated from greenshell mussels Perna canaliculus, the major toxin involved in neurotoxic shellfish poisoning in New Zealand
10. Isolation and structure of a new brevetoxin analog, brevetoxin B2, from greenshell mussels from New Zealand
11. Neurotoxic shellfish poisoning and brevetoxin metabolites: A case study from Florida