메뉴 건너뛰기




Volumn , Issue 65, 2003, Pages 145-155

The neuromelanin of human substantia nigra: Structure, synthesis and molecular behaviour

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL; IRON; LIPID; MELANIN; METAL; NEUROMELANIN; PESTICIDE; TOXIN; IRON CHELATING AGENT; LIPOFUSCIN; NERVE PROTEIN; NEUROPROTECTIVE AGENT;

EID: 0141975261     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0643-3_8     Document Type: Conference Paper
Times cited : (41)

References (83)
  • 1
    • 0026030199 scopus 로고
    • Biochemical of 1-methyl-4-phenyl-1,2,3,5-tetrahydropyridine toxicity: Could oxidative stress be involved in the brain?
    • Adams JD, Odunze IN (1991) Biochemical of 1-methyl-4-phenyl-1,2,3,5- tetrahydropyridine toxicity: could oxidative stress be involved in the brain? Biochem Pharmacol 41: 1099-1105
    • (1991) Biochem Pharmacol , vol.41 , pp. 1099-1105
    • Adams, J.D.1    Odunze, I.N.2
  • 2
    • 84981840783 scopus 로고
    • Melanin pigment in the central nervous system vertebrates
    • Adler A (1942) Melanin pigment in the central nervous system vertebrates. J Comp Neurol 76: 501
    • (1942) J Comp Neurol , vol.76 , pp. 501
    • Adler, A.1
  • 3
    • 0028115611 scopus 로고
    • Evidence for a glicid-lipid matrix in human neuromelanin, potentially responsible for the enhanced iron sequestering ability of substantia nigra
    • Aime S, Fasano M, Bergamasco B, Lopiano L, Valente G (1994) Evidence for a glicid-lipid matrix in human neuromelanin, potentially responsible for the enhanced iron sequestering ability of substantia nigra. J Neurochem 62: 369-371
    • (1994) J Neurochem , vol.62 , pp. 369-371
    • Aime, S.1    Fasano, M.2    Bergamasco, B.3    Lopiano, L.4    Valente, G.5
  • 4
    • 0014541594 scopus 로고
    • The histochemical relationship of neuromelanin and lipofuscin
    • Barden H (1969) The histochemical relationship of neuromelanin and lipofuscin. J Neuropathol Exp Neurol Baltimore 28: 419-441
    • (1969) J Neuropathol Exp Neurol Baltimore , vol.28 , pp. 419-441
    • Barden, H.1
  • 5
    • 0002117756 scopus 로고
    • Histochemical relationship and nature of neuromelanin
    • Barden H (1975) Histochemical relationship and nature of neuromelanin. Aging 1: 79-117
    • (1975) Aging , vol.1 , pp. 79-117
    • Barden, H.1
  • 6
    • 0014087823 scopus 로고
    • Studies on neuromelanin I. A melanin system in the human adult brainstem
    • Bazelon M, Fenichel GM (1967) Studies on neuromelanin I. A melanin system in the human adult brainstem. Neurology 17: 512-519
    • (1967) Neurology , vol.17 , pp. 512-519
    • Bazelon, M.1    Fenichel, G.M.2
  • 7
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington: Clinical, morphological and neurochemical correlations
    • Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington: clinical, morphological and neurochemical correlations. J Neurol Sci 20: 415-455
    • (1973) J Neurol Sci , vol.20 , pp. 415-455
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3    Jellinger, K.4    Seitelberger, F.5
  • 8
    • 0019428018 scopus 로고
    • A brainstem atlas of catecolaminergic neurons in man, using melanin as natural marker
    • Bogerts B (1981) A brainstem atlas of catecolaminergic neurons in man, using melanin as natural marker. J Comp Neurol 197: 63-80
    • (1981) J Comp Neurol , vol.197 , pp. 63-80
    • Bogerts, B.1
  • 9
    • 0032769875 scopus 로고    scopus 로고
    • The structure of neuromelanin and its iron binding site studied by infrared spectroscopy
    • Bridelli MG, Tampellini D, Zecca L (1999) The structure of neuromelanin and its iron binding site studied by infrared spectroscopy. Febs Lett 457: 18-22
    • (1999) Febs Lett , vol.457 , pp. 18-22
    • Bridelli, M.G.1    Tampellini, D.2    Zecca, L.3
  • 11
    • 0028491919 scopus 로고
    • X-Ray characterization of melanins-II
    • Cheng J, Moss SC and Eisner M (1994) X-Ray characterization of melanins-II. Pigment Cell Res 7: 263-273
    • (1994) Pigment Cell Res , vol.7 , pp. 263-273
    • Cheng, J.1    Moss, S.C.2    Eisner, M.3
  • 13
    • 0022536563 scopus 로고
    • The melanoneurons of the human cerebellum (nucleus pigmentosus cerebellaris) and homologues in the monkey
    • Cowen D (1986) The melanoneurons of the human cerebellum (nucleus pigmentosus cerebellaris) and homologues in the monkey. J Neuropathol Exp Neurol 45: 205-221
    • (1986) J Neuropathol Exp Neurol , vol.45 , pp. 205-221
    • Cowen, D.1
  • 14
    • 0002441031 scopus 로고
    • A spectroscopy study of the equine brain melanins
    • Milano
    • Cozzi B, Tozzi F (1985) A spectroscopy study of the equine brain melanins. Archo Vet It, Milano 36: 34-40
    • (1985) Archo Vet It , vol.36 , pp. 34-40
    • Cozzi, B.1    Tozzi, F.2
  • 15
    • 0023791524 scopus 로고
    • Neuromelanin in the substantia nigra of adult horses
    • Cozzi B, Pellegrini M, Droghi A (1988) Neuromelanin in the substantia nigra of adult horses. Anat Anz Jena 166: 53-61
    • (1988) Anat Anz Jena , vol.166 , pp. 53-61
    • Cozzi, B.1    Pellegrini, M.2    Droghi, A.3
  • 17
    • 0022539310 scopus 로고
    • Selectivity of the parkinsonian neurotoxin MPTP: Toxic metabolite MPP+ binds to neuromelanin
    • D'Amato RJ, Lipman ZP, Snyder SH (1986) Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin. Science 231: 987-989
    • (1986) Science , vol.231 , pp. 987-989
    • D'Amato, R.J.1    Lipman, Z.P.2    Snyder, S.H.3
  • 18
    • 0022967142 scopus 로고
    • Neuromelanic pigment in substantia nigra neurons of rats and dogs
    • DeMattei M, Levi AC, Fariello RG (1986) Neuromelanic pigment in substantia nigra neurons of rats and dogs. Neurosci Lett 72: 37-42
    • (1986) Neurosci Lett , vol.72 , pp. 37-42
    • DeMattei, M.1    Levi, A.C.2    Fariello, R.G.3
  • 19
    • 0024356620 scopus 로고
    • Increased nigral iron content and alteration in other metal ions occurring in brain in Parkinson's disease
    • Dexter DT, Wells FR, Lees AJ, Jenner I, Marsden CD (1989) Increased nigral iron content and alteration in other metal ions occurring in brain in Parkinson's disease. J Neurochem 52: 1830-1836
    • (1989) J Neurochem , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3    Jenner, I.4    Marsden, C.D.5
  • 21
    • 84937088414 scopus 로고
    • Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson's disease
    • Duffy PE, Tennyson VM (1965) Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson's disease. J Neuropathol Exp Neurol 24: 398-414
    • (1965) J Neuropathol Exp Neurol , vol.24 , pp. 398-414
    • Duffy, P.E.1    Tennyson, V.M.2
  • 22
    • 0027243726 scopus 로고
    • Purified human neuromelanin, synthetic dopamine melanin as a potential model pigment, and the normal human substantia nigra: Characterization by electron paramagnetic resonance spectroscopy
    • Enochs WS, Nilges MJ, Swartz HM (1993) Purified human neuromelanin, synthetic dopamine melanin as a potential model pigment, and the normal human substantia nigra: characterization by electron paramagnetic resonance spectroscopy. J Neurochem 61: 68-79
    • (1993) J Neurochem , vol.61 , pp. 68-79
    • Enochs, W.S.1    Nilges, M.J.2    Swartz, H.M.3
  • 23
    • 0028174370 scopus 로고
    • The roles of neuromelanin binding of metal ions, and oxidative cytotoxicity in the pathogenesis of Parkinson's disease: A hypothesis
    • Enochs WS, Sarna T, Zecca L, Riley PA, Swartz HM (1994) The roles of neuromelanin binding of metal ions, and oxidative cytotoxicity in the pathogenesis of Parkinson's disease: a hypothesis. J Neural Transm [PD-Sect] 7: 83-100
    • (1994) J Neural Transm [PD-Sect] , vol.7 , pp. 83-100
    • Enochs, W.S.1    Sarna, T.2    Zecca, L.3    Riley, P.A.4    Swartz, H.M.5
  • 24
    • 0014318797 scopus 로고
    • Studies on neuromelanin. II. Melanin in the brainstems of infants and children
    • Fenichel GM, Bazelon M (1968) Studies on neuromelanin. II. Melanin in the brainstems of infants and children. Neurology 18: 817-820
    • (1968) Neurology , vol.18 , pp. 817-820
    • Fenichel, G.M.1    Bazelon, M.2
  • 25
    • 0001393031 scopus 로고
    • On the nature of pigment granules in the cell of the locus coeruleus and substantia nigra
    • Foley JM, Baxter D (1958) On the nature of pigment granules in the cell of the locus coeruleus and substantia nigra. J Neuropathol Exp Neurol 7: 586-598
    • (1958) J Neuropathol Exp Neurol , vol.7 , pp. 586-598
    • Foley, J.M.1    Baxter, D.2
  • 26
    • 0022573434 scopus 로고
    • Occurrence and distribution of 5-S-cysteinyl derivates of dopamine, dopa and dopac in brains of eight mammalian species
    • Fornsted B, Rosengren E, Carlsson A (1986) Occurrence and distribution of 5-S-cysteinyl derivates of dopamine, dopa and dopac in brains of eight mammalian species. Neuropharmacology 25: 451-454
    • (1986) Neuropharmacology , vol.25 , pp. 451-454
    • Fornsted, B.1    Rosengren, E.2    Carlsson, A.3
  • 28
    • 0029845140 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man
    • Gerlach M, Riederer P (1996) Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man. J Neural Transm 103: 987-1041
    • (1996) J Neural Transm , vol.103 , pp. 987-1041
    • Gerlach, M.1    Riederer, P.2
  • 29
    • 0028990740 scopus 로고
    • Mössbauer spectroscopic studies of human neuromelanin isolated from the substantia nigra
    • Gerlach M, Trautwein AX, Zecca L, Youdim MBH, Riederer P (1995) Mössbauer spectroscopic studies of human neuromelanin isolated from the substantia nigra. J Neurochem 65: 923-926
    • (1995) J Neurochem , vol.65 , pp. 923-926
    • Gerlach, M.1    Trautwein, A.X.2    Zecca, L.3    Youdim, M.B.H.4    Riederer, P.5
  • 30
    • 0026638825 scopus 로고
    • Melanin, tyrosine hydroxylase, calbindin and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuronal susceptibility in Parkinson's disease
    • Gibb WRG (1992) Melanin, tyrosine hydroxylase, calbindin and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuronal susceptibility in Parkinson's disease. Brain Res 581: 283-291
    • (1992) Brain Res , vol.581 , pp. 283-291
    • Gibb, W.R.G.1
  • 31
    • 0025124659 scopus 로고
    • The anatomy of the human substantia nigra in relation to selective neuronal vulnerability
    • Streifler MB, Korczyn AD, Melamed E and Youdim MBH (eds) Raven Press, New York
    • Gibb WRG, Fearnley JM, Lees AJ (1990) The anatomy of the human substantia nigra in relation to selective neuronal vulnerability. In: Streifler MB, Korczyn AD, Melamed E and Youdim MBH (eds) Advances in neurology, vol 53. Parkinson's disease: anatomy, pathology and therapy. Raven Press, New York, pp 31-34
    • (1990) Advances in Neurology, Vol 53. Parkinson's Disease: Anatomy, Pathology and Therapy , vol.53 , pp. 31-34
    • Gibb, W.R.G.1    Fearnley, J.M.2    Lees, A.J.3
  • 32
    • 0026746512 scopus 로고
    • Neuromelanin containing neurons of the substantia nigra accumulate iron and aluminium in Parkinson's disease: A LAMMA study
    • Good PF, Olanow CW, Perl DP (1992) Neuromelanin containing neurons of the substantia nigra accumulate iron and aluminium in Parkinson's disease: a LAMMA study. Brain Res 593: 343-346
    • (1992) Brain Res , vol.593 , pp. 343-346
    • Good, P.F.1    Olanow, C.W.2    Perl, D.P.3
  • 33
    • 0018716807 scopus 로고
    • On the origin and significance of neuromelanin
    • Graham DG (1979) On the origin and significance of neuromelanin. Arch Pathol Lab Med (July) 103: 359-362
    • (1979) Arch Pathol Lab Med (July) , vol.103 , pp. 359-362
    • Graham, D.G.1
  • 34
    • 0031017290 scopus 로고    scopus 로고
    • Generation of reactive oxygen species by tyrosine hydroxilase: A possible contribution to the degeneration of dopaminergic neurons
    • Haavik J, Almas B, Flatmark T (1997) Generation of reactive oxygen species by tyrosine hydroxilase: a possible contribution to the degeneration of dopaminergic neurons. J Neurochem 68 (1): 328-332
    • (1997) J Neurochem , vol.68 , Issue.1 , pp. 328-332
    • Haavik, J.1    Almas, B.2    Flatmark, T.3
  • 35
    • 0028812293 scopus 로고
    • Enzymatic oxidation of dopamine: The role of prostaglandin H synthase
    • Hastings TG (1995) Enzymatic oxidation of dopamine: the role of prostaglandin H synthase. J Neurochem 64: 919-924
    • (1995) J Neurochem , vol.64 , pp. 919-924
    • Hastings, T.G.1
  • 36
    • 0014381841 scopus 로고
    • Electron microscopic studies on pigment granules in the substantia nigra and locus coeruleus of the Japanese monkey (macaca fuscata yukui)
    • Hirosawa K (1968) Electron microscopic studies on pigment granules in the substantia nigra and locus coeruleus of the Japanese monkey (macaca fuscata yukui). Z Zellforsch 88: 187-203
    • (1968) Z Zellforsch , vol.88 , pp. 187-203
    • Hirosawa, K.1
  • 38
    • 0023263919 scopus 로고
    • Biochemical pathophysiology of Parkinson's disease
    • Hornykiewicz O (1986) Biochemical pathophysiology of Parkinson's disease. Adv Neurol 45: 19-22
    • (1986) Adv Neurol , vol.45 , pp. 19-22
    • Hornykiewicz, O.1
  • 39
    • 0032480361 scopus 로고    scopus 로고
    • Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?
    • Ikemoto K, Nagatsu I, Ito S, King RA, Nishimura A, Nagatsu T (1998) Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra? Neurosci Lett 253: 198-200
    • (1998) Neurosci Lett , vol.253 , pp. 198-200
    • Ikemoto, K.1    Nagatsu, I.2    Ito, S.3    King, R.A.4    Nishimura, A.5    Nagatsu, T.6
  • 41
    • 0026662141 scopus 로고
    • Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?
    • Kastner A, Hirsch EC, Lejeune O, Javoy-Agid F, Rascol O, Agid Y (1992) Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? J Neurochem 59: 1080-1089
    • (1992) J Neurochem , vol.59 , pp. 1080-1089
    • Kastner, A.1    Hirsch, E.C.2    Lejeune, O.3    Javoy-Agid, F.4    Rascol, O.5    Agid, Y.6
  • 42
    • 0031738324 scopus 로고    scopus 로고
    • X-ray absorption fine-structure spectroscopy studies of iron sites in synthetic and natural neuromelanin
    • Kropf AJ, Bunker BA, Eisner M, Moss SC, Zecca L, Stroppolo A, Crippa PR (1998) X-ray absorption fine-structure spectroscopy studies of iron sites in synthetic and natural neuromelanin. Biophys J 75: 3135-3142
    • (1998) Biophys J , vol.75 , pp. 3135-3142
    • Kropf, A.J.1    Bunker, B.A.2    Eisner, M.3    Moss, S.C.4    Zecca, L.5    Stroppolo, A.6    Crippa, P.R.7
  • 44
    • 0022976953 scopus 로고
    • MPTP: Current concepts and controversies
    • Langston JW, Irwin I (1986) MPTP: current concepts and controversies. Clin Neuropharmacol 9: 485-507
    • (1986) Clin Neuropharmacol , vol.9 , pp. 485-507
    • Langston, J.W.1    Irwin, I.2
  • 45
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to product of meperidine-analog synthesis
    • Langston JW, Ballard P, Tetrud JW, Irwin I (1983) Chronic parkinsonism in humans due to product of meperidine-analog synthesis. Science 219: 979-980
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 46
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of human years after 1-metyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston JW, Forno LS, Tetrud J, Reeves AG, Kaplan JA, Karluk D (1999) Evidence of active nerve cell degeneration in the substantia nigra of human years after 1-metyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann Neurol 46: 598-605
    • (1999) Ann Neurol , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 49
    • 0016242482 scopus 로고
    • Lipoprotein pigments- their relationship to ageing in the human nervous system. II. The melanin content of pigmented nerve cells
    • Mann DMA, Yates PO (1974) Lipoprotein pigments- their relationship to ageing in the human nervous system. II. The melanin content of pigmented nerve cells. Brain 97: 489-498
    • (1974) Brain , vol.97 , pp. 489-498
    • Mann, D.M.A.1    Yates, P.O.2
  • 50
    • 0020509931 scopus 로고
    • Possible role of neuromelanin in the pathogenesis of Parkinson's disease
    • Mann DM, Yates PO (1983) Possible role of neuromelanin in the pathogenesis of Parkinson's disease. Mech Ageing Dev 21: 193-203
    • (1983) Mech Ageing Dev , vol.21 , pp. 193-203
    • Mann, D.M.1    Yates, P.O.2
  • 52
    • 0000902523 scopus 로고
    • Pigmentation in the nuculeus substantiae nigrae of mammals
    • Marsden CD (1961) Pigmentation in the nuculeus substantiae nigrae of mammals. J Anat 95: 1080-1089
    • (1961) J Anat , vol.95 , pp. 1080-1089
    • Marsden, C.D.1
  • 54
    • 0028969650 scopus 로고
    • Prostaglandin H synthetase-mediated metabolism of dopamine: Implication for Parkinson's Disease
    • Mattammal MB, Strong R, Lakshmi VM, Chung HD, Stephenson AH (1995) Prostaglandin H synthetase-mediated metabolism of dopamine: implication for Parkinson's Disease. J Neurochem 64: 1645-1654
    • (1995) J Neurochem , vol.64 , pp. 1645-1654
    • Mattammal, M.B.1    Strong, R.2    Lakshmi, V.M.3    Chung, H.D.4    Stephenson, A.H.5
  • 56
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer disease brains
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer disease brains. Neurology 38 (8): 1285-1291
    • (1988) Neurology , vol.38 , Issue.8 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 57
    • 0013914715 scopus 로고
    • Light and electron microscopic studies of pigment in human and rhesus monkey substantia nigra and locus coeruleus
    • Moses HL, Ganote CE, Beaver DL, Shuffman SS (1966) Light and electron microscopic studies of pigment in human and rhesus monkey substantia nigra and locus coeruleus. Anat Rec 155: 167-184
    • (1966) Anat Rec , vol.155 , pp. 167-184
    • Moses, H.L.1    Ganote, C.E.2    Beaver, D.L.3    Shuffman, S.S.4
  • 58
    • 0031914408 scopus 로고    scopus 로고
    • Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India
    • Muthane UB, Yasha TC, Shankar SK (1998) Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India. Ann Neurol 43: 283-287
    • (1998) Ann Neurol , vol.43 , pp. 283-287
    • Muthane, U.B.1    Yasha, T.C.2    Shankar, S.K.3
  • 60
    • 0030625743 scopus 로고    scopus 로고
    • The role of peroxidase in neuromelanin synthesis: A review
    • Okun MR (1997) The role of peroxidase in neuromelanin synthesis: a review. Physiol Chem Phys and Med NMR 29: 15-22
    • (1997) Physiol Chem Phys and Med NMR , vol.29 , pp. 15-22
    • Okun, M.R.1
  • 61
    • 0025964041 scopus 로고
    • The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method
    • Pakkenberg B, Moller A, Gundersen HJG, Mouritzen DA, Pakkenberg H (1991) The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J Neurol Neurosurg Psychiatry 54: 30-35
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 30-35
    • Pakkenberg, B.1    Moller, A.2    Gundersen, H.J.G.3    Mouritzen, D.A.4    Pakkenberg, H.5
  • 63
    • 0018190446 scopus 로고
    • Binding of dopaminergic drugs by the neuromelanin of the substantia nigra, synthetic melanins and melanin granules
    • Salazar M, Sokoloski TD, Patil PN (1978) Binding of dopaminergic drugs by the neuromelanin of the substantia nigra, synthetic melanins and melanin granules. Fed Proc 37: 2403-2407
    • (1978) Fed Proc , vol.37 , pp. 2403-2407
    • Salazar, M.1    Sokoloski, T.D.2    Patil, P.N.3
  • 65
    • 84981838147 scopus 로고
    • Melanin pigmentation of the substantia nigra in primates
    • Schrerer HJ (1939) Melanin pigmentation of the substantia nigra in primates. J Comp Neurol 71: 91
    • (1939) J Comp Neurol , vol.71 , pp. 91
    • Schrerer, H.J.1
  • 66
    • 17044461766 scopus 로고    scopus 로고
    • Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: An electron paramagnetic resonance spectroscopy study
    • Shima T, Sarna T, Stroppolo A, Gerbasi R, Swartz HM, Zecca L (1997) Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy study. Free Radic Biol Med 23: 110-119
    • (1997) Free Radic Biol Med , vol.23 , pp. 110-119
    • Shima, T.1    Sarna, T.2    Stroppolo, A.3    Gerbasi, R.4    Swartz, H.M.5    Zecca, L.6
  • 67
    • 0023224837 scopus 로고
    • Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,5-tetraydropiridine
    • Singer TP, Castagnoli N, Ramsay RR, Trevor AJ (1987) Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,5- tetraydropiridine. J Neurochem 49: 1-8
    • (1987) J Neurochem , vol.49 , pp. 1-8
    • Singer, T.P.1    Castagnoli, N.2    Ramsay, R.R.3    Trevor, A.J.4
  • 68
    • 0030597715 scopus 로고    scopus 로고
    • On the function of neuromelanin
    • Smythies J (1996) On the function of neuromelanin. Proc Roy Soc Lond B 263: 487-489
    • (1996) Proc Roy Soc Lond B , vol.263 , pp. 487-489
    • Smythies, J.1
  • 69
    • 0025963530 scopus 로고
    • Selective increase of iron in Substantia nigra zone compacta of parkinsonian brain
    • Sofic E, Paulus W, Jellinger K, Riederer P, Youdim MBH (1991) Selective increase of iron in Substantia nigra zone compacta of parkinsonian brain. J Neurochem 56: 978-982
    • (1991) J Neurochem , vol.56 , pp. 978-982
    • Sofic, E.1    Paulus, W.2    Jellinger, K.3    Riederer, P.4    Youdim, M.B.H.5
  • 71
    • 0026636487 scopus 로고
    • Modulation by neuromelanins of the availability and reactivity of metal ions
    • Swartz HM, Sarna T, Zecca L (1992) Modulation by neuromelanins of the availability and reactivity of metal ions. Ann Neurol 32: S69-S75
    • (1992) Ann Neurol , vol.32
    • Swartz, H.M.1    Sarna, T.2    Zecca, L.3
  • 72
    • 0031883023 scopus 로고    scopus 로고
    • New evidence for presence of tyrosinase in substantia nigra, forebrain, and midbrain
    • Tief K, Schmidt A, Beerman F (1998) New evidence for presence of tyrosinase in substantia nigra, forebrain, and midbrain. Mol Brain Res 53: 307-310
    • (1998) Mol Brain Res , vol.53 , pp. 307-310
    • Tief, K.1    Schmidt, A.2    Beerman, F.3
  • 73
    • 0016371033 scopus 로고
    • Biochemistry of neuromelanin
    • Van Woert MH, Ambani LM (1974) Biochemistry of neuromelanin. Adv Neurol 5: 215-223
    • (1974) Adv Neurol , vol.5 , pp. 215-223
    • Van Woert, M.H.1    Ambani, L.M.2
  • 74
    • 0026091762 scopus 로고
    • Cysteinyldopamine is not incorporated into neuromelanin
    • Wakamatsu K, Ito S and Nagatsu T (1991) Cysteinyldopamine is not incorporated into neuromelanin. Neurosci Lett 131: 57-60
    • (1991) Neurosci Lett , vol.131 , pp. 57-60
    • Wakamatsu, K.1    Ito, S.2    Nagatsu, T.3
  • 76
    • 0028999659 scopus 로고
    • The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems
    • Zareba M, Bober A, Korytowski W, Zecca L, Sarna T (1995) The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems. Biochim Biophys Acta 1271: 343-348
    • (1995) Biochim Biophys Acta , vol.1271 , pp. 343-348
    • Zareba, M.1    Bober, A.2    Korytowski, W.3    Zecca, L.4    Sarna, T.5
  • 77
    • 0027260711 scopus 로고
    • Total and paramagnetic metals in human substantia nigra and its neuromelanin
    • Zecca L, Swartz HM (1993) Total and paramagnetic metals in human substantia nigra and its neuromelanin. J Neural Transm [PD-Sect] 5: 203-213
    • (1993) J Neural Transm [PD-Sect] , vol.5 , pp. 203-213
    • Zecca, L.1    Swartz, H.M.2
  • 78
    • 0026544108 scopus 로고
    • The chemical characterization of melanin contained in substantia nigra of human brain
    • Zecca L, Mecacci C, Seraglia R, Parati E (1992) The chemical characterization of melanin contained in substantia nigra of human brain. Biochim Biophys Acta 1138: 6-10
    • (1992) Biochim Biophys Acta , vol.1138 , pp. 6-10
    • Zecca, L.1    Mecacci, C.2    Seraglia, R.3    Parati, E.4
  • 79
    • 0028006428 scopus 로고
    • Iron and other metals in neuromelanin, substantia nigra, and putamen of human brain
    • Zecca L, Pietra R, Goj C, Mecacci C, Radice D, Sabbioni E (1994) Iron and other metals in neuromelanin, substantia nigra, and putamen of human brain. J Neurochem 62: 1097-1101
    • (1994) J Neurochem , vol.62 , pp. 1097-1101
    • Zecca, L.1    Pietra, R.2    Goj, C.3    Mecacci, C.4    Radice, D.5    Sabbioni, E.6
  • 81
    • 0034024975 scopus 로고    scopus 로고
    • The interaction of human substantia nigra neuromelanin with lipids and peptides
    • Zecca L, Costi P, Mecacci C, Ito S, Terreni T, Sonnino S (2000) The interaction of human substantia nigra neuromelanin with lipids and peptides. J Neurochem 74: 1758-1765
    • (2000) J Neurochem , vol.74 , pp. 1758-1765
    • Zecca, L.1    Costi, P.2    Mecacci, C.3    Ito, S.4    Terreni, T.5    Sonnino, S.6
  • 82
    • 0035103932 scopus 로고    scopus 로고
    • Iron, neuromelanin and ferritin in substantia nigra of normal subjects at different ages. Consequences for iron storage and neurodegenerative disorders
    • Zecca L, Gallorini L, Schünemann V, Trautwein AX, Gerlach M, Riederer P, Vezzoni P, Tampellini D (2001) Iron, neuromelanin and ferritin in substantia nigra of normal subjects at different ages. Consequences for iron storage and neurodegenerative disorders. J Neurochem 76: 1766-1773
    • (2001) J Neurochem , vol.76 , pp. 1766-1773
    • Zecca, L.1    Gallorini, L.2    Schünemann, V.3    Trautwein, A.X.4    Gerlach, M.5    Riederer, P.6    Vezzoni, P.7    Tampellini, D.8
  • 83
    • 0037116582 scopus 로고    scopus 로고
    • The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
    • Zecca L, Fariello R, Riederer P, Sulzer D, Gatti A, Tampellini D (2002) The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease. FEBS Lett 510: 216-220
    • (2002) FEBS Lett , vol.510 , pp. 216-220
    • Zecca, L.1    Fariello, R.2    Riederer, P.3    Sulzer, D.4    Gatti, A.5    Tampellini, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.