Primary chemically induced tumors induce profound immunosuppression concomitant with apoptosis and alterations in signal transduction in T cells and NK cells

Cancer Research

Volumn 59, Issue 12, 1999, Pages 2950-2956

  Horiguchi, Shigetoshi ^a,b   Petersson, Max ^a,b   Nakazawa, Tsutomu ^a,b   Kanda, Minoru ^a,b   Zea, Arnold H ^c   Ochoa, Auguste C ^c   Kiessling, Rolf ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED CANCER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER IMMUNOLOGY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; IMMUNE DEFICIENCY; IMMUNOREACTIVITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD3; APOPTOSIS; CARCINOGENS; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; IMMUNE TOLERANCE; KILLER CELLS, NATURAL; METHYLCHOLANTHRENE; MICE; NEOPLASM TRANSPLANTATION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SARCOMA, EXPERIMENTAL; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS;

EID: 0033564834     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Baxevanis, C. N., and Papamichail, M. Characterization of the anti-tumor immune response in human cancers and strategies for immunotherapy. Crit. Rev. Oncol. Hematol., 16: 157-179, 1994.
2. Stutman, O. Immunodepression and malignancy. Adv. Cancer Res., 22: 261-422, 1975.
3. Elsasser-Beile, U., von Kleist, S., Fischer, R., Martin, M., Wetterauer, U., Gallati, H, and Monting, J. S. Impaired cytokine production in whole blood cell cultures of patients with urological carcinomas. J. Cancer Res. Clin. Oncol., 119: 430-433, 1993.
4. Bateman, W. J., Donnellan, I., Fraser, I. A., Wong, L. S., and Morris, A. G. Lymphocytes infiltrating colorectal cancer have low proliferative capacity but can secrete normal levels of interferon gamma. Cancer Immunol. Immunother., 41: 61-67, 1995.
5. Mizoguchi, H., O'Shea, J. J., Longo, D. L., Loeffler, C. M., McVicar, D. W., and Ochoa, A. C. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science (Washington DC), 258: 1795-1798, 1992.
6. Nakagomi, H., Petersson, M., Magnusson, I., Juhlin, C., Matsuda, M., Mellstedt, H., Taupin, J. L., Vivier, E., Anderson, P., and Kiessling, R. Decreased expression of the signal-transducing ζ chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res., 53: 5610-5612, 1993.
7. Finke, J. H., Zea, A. H., Stanley, J., Longo, D. L., Mizoguchi, H., Tubbs, R. R., Wiltrout, R. H., O'Shea, J. J., Kudoh, S., and Klein, E. Loss of T-cell receptor ζ chain and p56lck in T-cells infiltrating human renal cell carcinoma. Cancer Res., 53: 5613-5616, 1993.
8. Lai, P., Rabinowich, H., Crowley-Nowick, P. A., Bell, M. C., Mantovani, G., and Whiteside, T. L. Alternation in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma. Clin. Cancer Res., 2: 161, 1996.
9. Gunji, Y., Hori, S., Aoe, T., Asano, T. Ochiai, T., Isono, K., and Saito, T. High frequency of cancer patients with abnormal assembly of the T cell receptor-CD3 complex in peripheral blood T lymphocytes. Jpn. J. Cancer Res., 85: 1189-1192, 1994.
10. Kono, K., Ressing, M. E., Brandt, R. M., Melief, C. J., Potkul, R. K., Andersson, B., Petersson, M., Kast, M. W., and Kiessling, R. Decreased expression of signal transducing ζ chain on peripheral T cells and NK cells in patients with cervical cancer. Clin. Cancer Res., 2: 1825-1828, 1996.
11. Zea, A. H., Curti, B. D., Longo, D. L., Alvord, W. G., Strobi, S. L., Mizoguchi, H., Creekmore, S. P., and Ochoa, J. J. Alteration in T-cell receptor and signal transduction molecules in melanoma patients. Clin. Cancer Res., 1: 1327-1335, 1995.
12. Matsuda, M., Petersson, M., Lenkei, R., Taupin, J. L., Magnusson, I., Mellstedt, H., Anderson, P., and Kiessling, R. Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating, gut mucosal and peripheral lymphocytes: correlation with the stage of the disease. Int. J. Cancer, 61: 765-772, 1995.
13. Mulder, W. M., Bloemena, E., Stukart, M. J., Kummer, J. A., Wagstaff, J., and Scheper, R. J. T cell receptor-ζ and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma. Gut, 40: 113-119, 1997.
14. Levey, D. L., and Srivastava, P. K. Alterations in T cells of cancer-bearers: whence specificity? Immunol. Today, 17: 365-368, 1996.
15. Levey, D. L., and Srivastava, P. K. T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 ζ despite suppressed cytolytic activity. J. Exp. Med., 182: 1029-1036, 1995.
16. Ressing, M. E., Offringa, R., Toes, R. E., Ossendorp, F., de Jong, J. H., Brandt, R. M., Kast, W. M., and Melief, C. J. Immunotherapy of cancer by peptide-based vaccines for the induction of tumor-specific T cell immunity. Immunotechnology, 2: 241-251, 1996.
17. Rosenberg, S. A., Lotze, M. T., Muul, L. M., Chang, A. E., Avis, F. P., Leitman, S., Linehan, W. M., Robertson, C. N., Lee, R. E., and Rubin, J. T. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N. Engl. J. Med., 316: 889-897, 1987.
18. Klein, G. H. O., Sjogren, E., and Hellstrom, K. E. Demonstration of resistance against Methylcholanthrene-induced sarcomas in primary autologous host. Cancer Res., 20: 1561, 1960.
19. Hansen, M. B., Nielsen, S. E., and Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods, 119: 203-210, 1989.
20. Pawelec, G., Zeuthen, J., and Kiessling R. Escape from host-antitumor immunity. Crit. Rev. Oncog., 8: 111-141, 1997.
21. Alfred, L. J., Wojdani, A., Nieto, M., Perez, R., and Yoshida, G. A chemical carcinogen, 3-melhylcholanthrene, alters T-cell function and induces T-suppressor cells in a mouse model system. Immunology, 50: 207-213, 1983.
22. Levy, R. L., Barrington, M. H., Lerner, R. A., Griffin, G. F., and Whitmire, C. E. Immunosuppressive effects of 3-methylcholanthrene given intratracheally in various inbred strains of mice. Cancer Res., 37: 3892-3894, 1977.
23. Ressing, M. E., van Driel, W. J., Celis, E., Sette, A., Brandt, M. P., Hartman, M., Anholts, J. D., Schreuder, G. M., ter Harmsel, W. B., Fleuren, G. J., Trimbos, B. J., Kast, W. M., and Melief, C. J. Occasional memory cytotoxic T-cell responses of patients with human papillomavirus type 16-positive cervical lesions against a human leukocyte antigen-A*0201-restricted E7-encoded epitope. Cancer Res., 56: 582-588, 1996.
24. Scheibenbogen, C., Lee, K. H., Stevanovic, S., Witzens, M., Willhauck, M., Waldmann, V., Naeher, H., Rammensee, H. G., and Keilholz, U. Analysis of the T cell response to tumor and viral peptide antigens by an IFN-γ-ELISPOT assay. Int. J. Cancer, 71: 932-936, 1997.
25. Salvadori, S., and Zier, K. Molecular basis of T cell dysfunction in cancer is influenced by the paracrine secretion of tumor-derived IL-2. J. Immunol., 156: 2927-2932, 1996.
26. Kono, K., Salazar-Onfray, F., Petersson, M., Hansson, J., Masucci, G., Wasserman, K., Nakazawa, T., Anderson, P., and Kiessling, R. Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing ζ molecules and inhibits tumor-specific T cell- and natural killer cell-mediated cytotoxicity. Eur. J. Immunol., 26: 1308-1313, 1996.
27. Otsuji, M., Kimura, Y., Aoe, T., Okamoto, Y., and Saito, T. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses. Proc. Natl. Acad. Sci. USA, 93: 13119-13124, 1996.
28. Walker, P. R., Saas, P., and Dietrich, P. Y. Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back. J. Immunol., 158: 4521-4524, 1997.
29. Hansson, M., Asea, A., Ersson, U., Hermodsson, S., and Hellstrand, K. Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites. J. Immunol., 156: 42-47, 1996.
30. Wesch, D., Marx, S., and Kabelitz, D. Monocyte-dependent death of freshly isolated T lymphocytes: induction by phorbolester and mitogens and differential effects of catalase. J. Immunol., 161: 1248-1256, 1998.
31. Rabinowich, H., Reichert, T. E., Kashii, Y., Gastman, B. R., Bell, M. C., and Whiteside, T. L. Lymphocyte apoptosis induced by Fas ligand-expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes. J. Clin. Invest., 101: 2579-2588, 1998.
32. Bauer, M. K. A., Vogt, M., Los, M., Siegel, J., Wesselborg, S., and Schulze-Osthoff, K. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression. J. Biol. Chem., 273: 8048-8055, 1998.
33. Vogt, M., Bauer, M. K., Ferrari, D., and Schulze-Osthoff, K. Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO-1/Fas) ligand expression in microglial cells. FEBS Lett., 429: 67-72, 1998.
34. Franco, J. L., Ghosh, P., Wiltrout, R. H., Carter, C. R., Zea, A. H., Momozaki, N., Ochoa, A. C., Longo, D. L., Sayers, T. J., and Komschlies, K. L. Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice. Cancer Res., 55: 3840-3846, 1995.