Differential roles of VLA-4(CD49d/CD29) and LFA-1(CD11a/CD18) integrins and E- and P-selectin during developing and established active or adoptively transferred adjuvant arthritis in the rat

Immunology and Cell Biology

Volumn 81, Issue 5, 2003, Pages 397-408

  Issekutz, Andrew C ^a   Nakazato, Satoru ^b   Issekutz, Thomas B ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Inflammation; Leucocyte; Lymphocyte; Migration; Monocyte; Neutrophil; T cell

Indexed keywords

ALPHA4 INTEGRIN; BETA1 INTEGRIN; CHROMIUM 51; CONCANAVALIN A; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INDIUM 111; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY; PADGEM PROTEIN;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN FUNCTION; AUTOIMMUNE DISEASE; CELL TRANSFER; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; HISTOPATHOLOGY; IMMUNIZATION; IN VITRO STUDY; ISOTOPE LABELING; LYMPH NODE; MALE; MONOCYTE; MYCOBACTERIUM BUTYRICUM; NEUTROPHIL; NONHUMAN; PATHOGENESIS; RAT; REVIEW; SCORING SYSTEM; SPLEEN; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS, EXPERIMENTAL; E-SELECTIN; INTEGRIN ALPHA4BETA1; JOINTS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; P-SELECTIN; RATS; RATS, INBRED LEW; T-LYMPHOCYTES;

ANIMALIA; MYCOBACTERIUM; MYCOBACTERIUM BUTYRICUM;

EID: 0141890057     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.2003.01187.x     Document Type: Review

References (43)

1. Kubes P, Ward PA. Leukocyte recruitment and the acute inflammatory response. Brain Pathol. 2000; 10: 127-35.
2. Ley K, Tedder TF. Leukocyte interactions with vascular endothelium; new insights into selectin-mediated attachment and rolling. J. Immunol. 1995; 155: 525-8.
3. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu. Rev. Physiol. 1995; 57: 827-72.
4. Von Andrian UH, Mackay Cr. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 2000; 343: 1020-34.
5. Smith MD, Slavotinek J, Au V, Weedon H et al. Successful treatment of rheumatoid arthritis is associated with a reduction in synovial membrane cytokines and cell adhesion molecule expression. Rheumatology (Oxford) 2001; 40: 965-77.
6. Carson CW, Beall LD, Hunder GG, Johnson CM, Newman W. Soluble E-selectin is increased in inflammatory synovial fluid. J. Rheumatol. 1994; 21: 605-11.
7. Grober JS, Bowen BL, Ebling H et al. Monocyte-endothelial adhesion in chronic rheumatoid arthritis. In situ detection of selectin and integrin-dependent interactions. J. Clin. Invest. 1993; 91: 2609-19.
8. Ilgner S, Stiehl P. Strong LFA-1 and VCAM-1 expression in histological type II of rheumatoid arthritis. Cell. Mol. Biol. 2002; 48: OL243-9.
9. Bloom BJ, Nelson SM, Alario AJ, Miller LC, Schaller JG. Synovial fluid levels of E-selectin and intercellular adhesion molecule-1: relationship to joint inflammation in children with chronic arthritis. Rheumatol. Int. 2002; 22: 175-7.
10. Klimiuk PA, Sierakowski S, Latosiewicz R et al. Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis. Ann. Rheum. Dis. 2002; 61: 804-9.
11. Harris E, D. ed. Joints and connective tissue: The targets of rheumatoid arthritis. In: Harris E, D. ed. Rheumatoid Arthritis. Toronto: W.B. Saunders Company, 1997; 3-17.
12. Taurog JD, Argentieri DC, McReynolds RA. Adjuvant arthritis. Methods Enzymol. 1988; 162: 339-55.
13. Taurog JD, Sandberg GP, Mahowald ML. The cellular basis of adjuvant arthritis. II. Characterization of the cells mediating passive transfer. Cell. Immunol. 1983; 80: 198-204.
14. Taurog JD, Sandberg GP, Mahowald ML. The cellular basis of adjuvant arthritis. 1. Enhancement of cell-mediated passive transfer by concanavalin A and by immunosuppressive pretreatment of the recipient. Cell. Immunol. 1983; 75: 271-82.
15. Van Eden W, Hogervorst EJ, Hensen EJ, van der Zee R, van Embden JD, Cohen IR. A cartilage-mimicking T-cell epitope on a 65K mycobacterial heat-shock protein: adjuvant arthritis as a model for human rheumatoid arthritis. Curr. Top Microbiol. Immunol. 1989; 145: 27-43.
16. Issekutz AC, Issekutz TB. Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms. J. Exp. Med. 1995; 181: 1197-203.
17. Issekutz AC, Issekutz TB. A major portion of polymorphonuclear leukocyte and T lymphocyte migration to arthritic joints in the rat is via LFA-1/MAC-1-independent mechanisms. Clin. Immunol. Immunopathol. 1993; 67: 257-63.
18. Issekutz TB, Miyasaka M, Issekutz AC. Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation. J. Exp. Med. 1996; 183: 2175-84.
19. Walter UM, Issekutz AC. The role of E- and P-selectin in neutrophil and monocyte migration in adjuvant-induced arthritis in the rat. Eur. J. Immunol. 1997; 27: 1498-505.
20. Walter UM, Issekutz AC. Role of E- and P-selectin in migration of monocytes and polymorphonuclear leucocytes to cytokine and chemoattractant-induced cutaneous inflammation in the rat. Immunology 1997; 92: 290-9.
21. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell. Biol. 1995; 128: 1243-53.
22. Berlin C, Bargatze RF, Campbell JJ et al. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell. 1995; 80: 413-22.
23. Johnston B, Issekutz TB, Kubes P. The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J. Exp. Med. 1996; 183: 1995-2006.
24. Issekutz TB. Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo. J. Immunol. 1991; 147: 4178-84.
25. Issekutz AC, Issekutz TB. Quantitation and kinetics of polymorphonuclear leukocyte and lymphocyte accumulation in joints during adjuvant arthritis in the rat. Lab. Invest. 1991; 64: 656-63.
26. Issekutz AC, Mu JY, Liu G, Melrose J, Berg EL. E-selectin, but not P-selectin, is required for development of adjuvant-induced arthritis in the rat. Arthritis Rheum. 2001; 44: 1428-37.
27. Birner U, Issekutz TB, Walter U, Issekutz AC. The role of alpha (4) and LFA-1 integrins in selectin-independent monocyte and neutrophil migration to joints of rats with adjuvant arthritis. Int. Immunol. 2000; 12: 141-50.
28. Henderson RB, Lim LH, Tessier PA et al. The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils. J. Exp. Med. 2001; 194: 219-26.
29. Gaboury JP, Kubes P. Reductions in physiologic shear rates lead to CD11/CD18-dependent, selectin-independent leukocyte rolling in vivo. Blood 1994; 83: 345-50.
30. Wolitzky BA. The role of E-selectin and P-selectin in inflammatory disease. In: Peltz G, (ed). Leukocyte recruitment in inflammatory disease. New York: Springer; 1996; 211-45.
31. Bullard DC, Mobley JM, Justen JM et al. Acceleration and increased severity of collagen-induced arthritis in P- selectin mutant mice. J. Immunol. 1999; 163: 2844-9.
32. Leussink I, Zettl K, Jander S, Pepinsky B, Lobb R, Stoll G, Toyka V, Gold R. Blockade of signaling via the very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) causes increased T cell apoptosis in experimental autoimmune neuritis. Acta. Neuropathol. (Berl.) 2002; 103: 131-6.
33. Westermann J, Engelhardt B, Hoffman JC. Migration of T cells in vivo: molecular mechanisms and clinical implications. Ann. Intern. Med. 2001; 135: 279-95.
34. Kanda E, Jin ZH, Mizuchi D, Arai A, Miura O. Activation of Rac and tyrosine phosphorylation of cytokine receptors induced by cross-linking of integrin alpha4beta1 and cell adhesion in hematopoietic cells. Biochem. Biophys. Res. Commun. 2003; 301: 934-40.
35. May AE, Neumann FJ, Schomig A, Preissner KT. VLA-4 (alpha(4)beta(1)) engagement defines a novel activation pathway for beta(2) integrin-dependent leukocyte adhesion involving the urokinase receptor. Blood 2000; 96: 506-13.
36. Lobb RR, Abraham WM, Burkly LC et al. Pathophysiologic role of α4 integrins in the lung. Ann. N.Y. Acad. Sci. 1996; 796: 113-23.
37. Issekutz AC, Issekutz TB. The role of E-selectin, P-selectin, and very late activation antigen-4 in T lymphocyte migration to dermal inflammation. J. Immunol. 2002; 168: 1934-9.
38. Knibbs RN, Craig RA, Maly P et al. Alpha(1,3)-fucosyltransferase VII-independent synthesis of P- and E- selectin ligands on cultured T lymphoblasts. J. Immunol. 1998; 161: 6305-15.
39. Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J. Immunol. 1999; 162: 3193-201.
40. Schottelius AJ, Hamann A, Asadullah K. Role of fucosyltransferases in leukocyte trafficking: major impact for cutaneous immunity. Trends Immunol. 2003; 24: 101-4.
41. Berg EL, Yoshino T, Rott LS et al. The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J. Exp. Med. 1991; 174: 1461-6.
42. Jakubowski A, Ehrenfels BN, Pepinsky RB, Burkly LC. Vascular cell adhesion molecule-Ig fusion protein selectively targets activated alpha 4-integrin receptors in vivo. Inhibition of autoimmune diabetes in an adoptive transfer model in nonobese diabetic mice. J. Immunol. 1995; 155: 938-46.
43. Hamann A, Klugewitz K, Austrup F, Jablonski-Westrich D. Activation induces rapid and profound alterations in the trafficking of T cells. Eur. J. Immunol. 2000; 30: 3207-18.