Inulin stimulates NO synthesis via activation of PKC-α and protein tyrosine kinase, resulting in the activation of NF-κB by IFN-γ-primed RAW 264.7 cells

Journal of Nutritional Biochemistry

Volumn 14, Issue 10, 2003, Pages 598-605

  Koo, Hyun Na ^a,b   Hong, Seung Heon ^b   Seo, Han Geuk ^c   Yoo, Taek Soo ^b   Lee, Ki Nam ^b   Kim, Nam Song ^d   Kim, Cheorl Ho ^e   Kim, Hyung Min ^a  

^a Kyung Hee University   (South Korea)

^b Wonkwang University   (South Korea)

^c Gyeongsang National University   (South Korea)

^d Wonkwang University School of Medicine   (South Korea)

^e Dongguk University   (South Korea)

Author keywords

Inulin; NF kappa B (Nuclear factor kappa B); Nitric Oxide (NO); PKC (protein kinase C) alpha; Protein tyrosine kinase; RAW 264.7 cells

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INULIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C ALPHA; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TYRPHOSTIN;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG POTENTIATION; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; MACROPHAGE; MOUSE; NONHUMAN; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

EID: 0141888291     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2003.07.002     Document Type: Article

References (36)

1. De Bruyn A., Alvarez A.P., Sandra P., DeLeenheer L. Isolation and identification of O-á-D-fructosuranosyl-(2→1)-D-fructose a product of the enzymatic hydrolysis of the inulin from Chicorium intybus . Carbohydrate Res. 235:1992;303-308.
2. Reddy B.S., Hamid R., Rao C.V. Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis. 18:1997;1371-1374.
3. Roberfroid M.B., Van Loo J.A., Gibson G.R. The bifidogenic nature of chicory inulin and its hydrosis products. J Nutr. 128:1998;11-19.
4. Reddy B.S. Possible mechanisms by which pro- and prebiotics influence colon carcinogenesis and tumor growth. J Nutr. 129:1999;1478S-1482S.
5. Kim M., Shin H.K. The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats. J Nutr. 128:1998;1731-1736.
6. Ohta K., Hamada S., Nakamura T. Production of high concentrations of ethanol from inulin by simultaneous saccharification and fermentation using Aspergillus niger and Saccharomyces cerevisiae. Appl Environ Microbiol. 59:1993;729-733.
7. Son K., Kim Y.M. In vivo cisplatin-exposed macrophages increase immunostimulant-induced nitric oxide synthesis for tumor cell killing. Cancer Res. 55:1995;5524-5527.
8. Hajri A., Metzger E., Vallat F., Coffy S., Flatter E., Evrard S., Marescaux J., Aprahamian M. Role of nitric oxide in pancreatic tumour growth in vivo and in vitro studies . Br J Cancer. 78:1998;841-849.
9. Nascimento F.R., Ribeiro-Dias F., Russo M. Cytotoxic activity of BCG-activated macrophages against L929 tumor cells is nitric oxide-dependent. Braz J Med Biol Res. 31:1998;1593-1596.
10. Ribeiro-Dias F., Russo M., Nascimento F.R., Barbuto J.A., Timenetsky J., Jancar S. Thioglycollate-elicited murine macrophages are cytotoxic to Mycoplasma arginini-infected YAC-1 tumor cells. Braz J Med Biol Res. 31:1998;1425-1428.
11. Palmer R.M., Ashton D.S., Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 333:1988;664-666.
12. Hibbs J.B., Taintor R.R., Vavrin Z. Macrophage cytotoxicity role for L-arginine deiminase and imino nitrogen oxidation to nitrite . Science. 235:1987;473-476.
13. Chen C.C., Wang J.K., Lin S.B. Antisense oligonucleotides targeting protein kinase C-alpha, -beta I, or -delta but not -eta inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages involvement of a nuclear factor kappa B-dependent mechanism . J Immunol. 161:1998;6206-6214.
14. Fujihara M., Connolly N., Ito N., Suzuki T. Properties of protein kinase C isoforms (beta II, epsilon, and zeta) in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production. J Immunol. 152:1994;1898-1906.
15. Liu M.K., Herrera-Velit P., Brownsey R.W., Reiner N.E. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J Immunol. 153:1994;2642-2652.
16. Zheng L., Zomerdijk T.P., Aarnoudse C., van Furth R., Nibbering P.H. Role of protein kinase C isozymes in Fc gamma receptor-mediated intracellular killing of Staphylococcus aureus by human monocytes. J Immunol. 155:1995;776-784.
17. Mishak H., Kolch W., Goodnight J., Davidson W.F., Rapp U., Rose-John S., Mushinski J.F. Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific. J Immunol. 147:1991;3981-3987.
18. Adamson P., Tighe M., Pearson J. Protein kinase inhibitors act downstream of IL-1 alpha and LPS stimulated MAP-kinase phosphorylation to inhibit expression of E-selection on human umbilical vain endothelial cells. Cell Adhes Commun. 3:1996;511-525.
19. Corbett J.A., Kwon G., Marino M., Rodi C.P., Sullivan P., Turk J., McDaniel L. Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets. Am J Physiol. 270:1996;1581-1587.
20. Mishra S., Mathur R., Hamburger A.W. Modulation of the cytoxic activity of tumor necrosis factor by protein tyrosine kinase and protein tyrosine phosphatase inhibitors. Lyphokine Cytokine Res. 13:1994;77-83.
21. Chen F., Sun S.C., Kuh D.C., Gaydos L.J., Demers L.M. Essential role of NF-kappa B activation in silica-induced inflammatory mediator production in macrophages. Biochem Biophys Res Commun. 214:1995;985-992.
22. Baeuerle P.A., Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 12:1994;141-179.
23. Mulsch A., Schray-Utz B., Mordvintcev P.I., Hauschildt S., Busse R. Diethyldithiocarbamate inhibits induction of macrophage NO synthase. FEBS Lett. 321:1993;215-218.
24. Kim H.M., Lee Y.M. Role of TGF-beta 1 on the IgE-dependent anaphylaxis reaction. J Immunol. 162:1999;4960-4965.
25. Jeong H., Koo H., Oh E., Chae H., Kim H., Suh S., Kim C., Cho K., Park B., Park S., Lee Y., Kim H. Nitric oxide production by high molecular weight water-soluble chitosan via nuclear factor-kappaB activation. Int J Immunopharmacol. 22:2000;923-933.
26. Peunova N., Enikolopov G. Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells. Nature. 375:1995;68-73.
27. Garthwaite J., Charles S.L., Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature. 336:1988;385-388.
28. Weinstein S.L., Sanghera J.S., Lemke K., DeFranco A.L., Pelech S.L. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J Biol Chem. 267:1992;14955-14962.
29. Xie Q.W., Kashiwabara Y., Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem. 269:1994;4705-4708.
30. Nishiya T., Uehara T., Kaneko M., Nomura Y. Involvement of nuclear factor-κB (NF-κB) signaling in the expression of inducible nitric oxide synthase (iNOS) gene in rat C6 glioma cells. Biochem Biophys Res Commun. 275:2000;268-273.
31. Belosevic M., Finbloom D.S., Meltzer M.S., Nacy C.A. IL-2 a cofactor for induction of activated macrophage resistance to infection . J Immunol. 145:1990;831-839.
32. Nathan C., Xie Q.W. Regulation of the biosynthesis of nitric oxide. J Biol Chem. 269:1994;13725-13728.
33. Lowenstein C.J., Alley E.W., Raval P., Snowman A.M., Snyder S.H., Russell S.W., Murphy W.J. Macrophage nitric oxide synthase gene two upstream regions mediate induction by interferon-γ and lipopolysaccharide . Proc Natl Acad USA. 90:1993;9730-9734.
34. Didonato J.A., Mercurio F., Karin M. Phosphorylation of IκB-α precedes but is not sufficient for its dissociation from NF-κB. Mol Cell Biol. 15:1995;1302-1311.
35. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:1992;3051-3064.
36. Roberfroid M.B. Chicory fructooligosaccharides and the gastrointestinal tract. Nutrition. 16:2000;677-679.