A new retroelement constituted by a natural alternatively spliced RNA of murine replication-competent retroviruses

EMBO Journal

Volumn 22, Issue 18, 2003, Pages 4866-4875

  Houzet, Laurent ^a,b   Battini, Jean Luc ^a   Bernard, Eric ^b   Thibert, Valerie ^a   Mougel, Marylène ^a,b  

^a CNRS   (France)

^b Dept of Infections Retrovirales   (France)

Author keywords

Defective retrovirus; Gag translation; RNA encapsidation; Viral RNA splicing; Virion assembly

Indexed keywords

GAG PROTEIN; POLYPROTEIN; SD' RNA; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EMBRYO; HOST RANGE; HUMAN; HUMAN CELL; LIFE CYCLE; MOUSE; MURINE LEUKEMIA VIRUS; NEW SPLICE DONOR ASSOCIATED RETROELEMENT; NONHUMAN; PRIORITY JOURNAL; RETROPOSON; RETROVIRUS; RNA SPLICING; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; VIRION; VIRUS ASSEMBLY; VIRUS GENE; VIRUS REPLICATION; VIRUS STRAIN;

ALTERNATIVE SPLICING; ANIMALS; LEUKEMIA VIRUS, MURINE; MICE; RESTRICTION MAPPING; RETROELEMENTS; RNA, MESSENGER; RNA, VIRAL; VIRAL PROTEINS; VIRUS REPLICATION;

ANIMALIA; MURINAE; MURINE LEUKEMIA VIRUS; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 0141848658     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg450     Document Type: Article

References (43)

1. Aldovini, A. and Young, R.A. (1990) Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of non infectious virus. J. Virol., 64, 1920-1926.
2. Alin, K. and Goff, S.P. (1996a) Amino acid substitutions in the CA protein of Moloney murine leukemia virus that block early events in infection. Virology, 222, 339-351.
3. Alin, K. and Goff, S.P. (1996b) Mutational analysis of interactions between the Gag precursor proteins of murine leukemia viruses. Virology, 216, 418-424.
4. Audit, M., Dejardin, J., Hohl, B., Sidobre, C., Hope, T.J., Mougel, M. and Sitbon, M. (1999) Introduction of a cis-acting mutation in the capsid-coding gene of moloney murine leukemia virus extends its leukemogenic properties. J. Virol., 73, 10472-10479.
5. Berlioz, C. and Darlix, J.L. (1995) An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors. J. Virol., 69, 2214-2222.
6. Brown, P.O., Bowerman, B., Varmus, H.E. and Bishop, J.M. (1989) Retroviral integration: structure of the initial covalent product and its precursor and a role for the viral IN protein. Proc. Natl Acad. Sci. USA, 86, 2525-2529.
7. Butler, S.L., Hansen, M.S. and Bushman, F.D. (2001) A quantitative assay for HIV DNA integration in vivo. Nat. Med., 7, 631-634.
8. Chen, B.K., Rousso, I., Shim, S. and Kim, P.S. (2001) Efficient assembly of an HIV-1/MLV Gag-chimeric virus in murine cells. Proc. Natl Acad. Sci. USA, 98, 15239-15244.
9. Corbin, A. and Darlix, J.L. (1996) Functions of the 5′ leader of murine leukemia virus genomic RNA in virion structure, viral replication and pathogenesis and MLV-derived vectors. Biochimie, 78, 632-638.
10. Corbin, A., Prats, A.C., Darlix, J.L. and Sitbon, M. (1994) A nonstructural gag-encoded glycoprotein precursor is necessary for efficient spreading and pathogenesis of murine leukemia viruses. J. Virol., 68, 3857-3867.
11. Cosset, F.L., Morling, F.J., Takeuchi, Y., Weiss, R.A., Collins, M.K. and Russell, S.J. (1995) Retroviral retargeting by envelopes expressing an N-terminal binding domain. J. Virol., 69, 6314-6322.
12. D'Souza, V., Melamed, J., Habib, D., Pullen, K., Wallace, K. and Summers, M.F. (2001) Identification of a high affinity nucleocapsid protein binding element within the Moloney murine leukemia virus Psi-RNA packaging signal: implications for genome recognition. J. Mol. Biol., 314, 217-232.
13. Dejardin, J., Bompard-Marechal, G., Audit, M., Hope, T.J., Sitbon, M. and Mougel, M. (2000) A novel subgenomic murine leukemia virus RNA transcript results from alternative splicing. J. Virol., 74, 3709-3714.
14. Edwards, S.A. and Fan, H. (1979) gag-related polyproteins of Moloney murine leukemia virus: evidence for independent synthesis of glycosylated and unglycosylated forms. J. Virol., 30, 551-563.
15. Evans, L.H., Dresler, S. and Kabat, D. (1977) Synthesis and glycosylation of polyprotein precursors to the internal core proteins of Friend murine leukemia virus. J. Virol., 24, 865-874.
16. Fan, H. (1997) Leukemogenesis by Moloney murine leukemia virus: a multistep process. Trends Microbiol., 5, 74-82.
17. Felder, M.P., Laugier, D., Yatsula, B., Dezelee, P., Calothy, G. and Marx, M. (1994) Functional and biological properties of an avian variant long terminal repeat containing multiple A to G conversions in the U3 sequence. J. Virol., 68, 4759-4767.
18. Gorelick, R.J., Nigida, S.M., Bess, J.W., Arthur, L.O., Henderson, L.E. and Rein, A. (1990) Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J. Virol., 64, 3207-3211.
19. Graham, F.L. and van der Eb, A.J. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52. 456-467.
20. Hermida-Matsumoto, L. and Resh, M.D. (2000) Localization of human immunodeficiency virus type 1 Gag and Env at the plasma membrane by confocal imaging. J. Virol., 74, 8670-8679.
21. Jones, T.A., Blaug, G., Hansen, M. and Barklis, E. (1990) Assembly of gag-β-galactosidase proteins into retrovirus particles. J. Virol., 64, 2265-2279.
22. Jonsson, C.B., Donzella, G.A., Gaucan, E., Smith, C.M. and Roth, M.J. (1996) Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysis. J. Virol., 70, 4585-4597.
23. Kieman, R.E., Ono, A., Englund, G. and Freed, E.O. (1998) Role of matrix in an early postentry step in the human immunodeficiency virus type 1 life cycle. J. Virol., 72, 4116-4126.
24. Leis, J. et al. (1988) Standardized and simplified nomenclature for proteins common to all retroviruses. J. Virol., 62, 1808-1809.
25. Lund, A.H. et al. (2002) Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat. Genet., 32, 160-165.
26. Mann, R., Mulligan, R.C. and Baltimore, D. (1983) Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell, 33, 153-159.
27. Mougel, M., Zhang, Y. and Barklis, E. (1996) Cis-active structural motifs involved in specific encapsidation of Moloney murine leukemia virus RNA. J. Virol., 70, 5043-5050.
28. Muriaux, D. and Rein, A. (2003) Encapsidation and transduction of cellular genes by retroviruses. Front. Biosci., 8, D135-D142.
29. Prats, A.C., DeBilly, G., Wang, P. and Darlix, J.L. (1989) CUG initiation codon used for the synthesis of a cell surface antigen coded by murine leukemia virus. J. Mol. Biol., 205, 363-372.
30. Saib, A., Peries, J. and de The, H. (1993) A defective human foamy provirus generated by pregenome splicing. EMBO J., 12, 4439-4444.
31. Saib, A., Koken, M.H., van der Spek, P., Peries, J. and de The, H. (1995) Involvement of a spliced and defective human foamy virus in the establishment of chronic infection. J. Virol., 69, 5261-5268.
32. Saris, C.J.M., van Eenbergen, J., Liskamp, R.M.J. and Bloemers, H.P.J. (1983) Structure of glycosylated and unglycosylated Gag and Gag-Pol precursor proteins of Moloney murine leukemia virus. J. Virol., 46, 841-859.
33. Shen-Ong, G.L. (1987) Alternative internal splicing in c-myb RNAs occurs commonly in normal and tumor cells. EMBO J., 6, 4035-4039.
34. Sitbon, M., Ellerbrok, H., Pozo, F., Nishio, J., Hayes, S.F., Evans, L. and Chesebro, B. (1990) Sequences in the U5-gag-pol region influence early and late pathogenic effects of Friend and Moloney murine leukemia viruses. J. Virol., 64, 2135-2140.
35. Soneoka, Y., Cannon, P.M., Ramsdale, E.E., Griffiths, J.C., Romano, G., Kingsman, S.M. and Kingsman, A.J. (1995) A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res., 23, 628-633.
36. Stuhlmann, H. and Berg, P. (1992) Homologous recombination of copackaged retrovirus RNAs during reverse transcription. J. Virol., 66, 2378-2388.
37. Suzuki, T., Shen, H., Akagi, K., Morse, H.C., Malley, J.D., Naiman, D.Q., Jenkins, N.A. and Copeland, N.G. (2002) New genes involved in cancer identified by retroviral tagging. Nat. Genet., 32, 166-174.
38. Tanese, N., Roth, M.J. and Goff, S.P. (1986) analysis of retroviral pol gene products with antisera raised against fusion proteins produced in E.coli. J. Virol., 59, 328-340.
39. VanBeveren, C., Goddard, J.G., Bems, A. and Verma, I.M. (1980) Structure of Moloney murine leukemia viral DNA: nucleotide sequence of the 5′ long terminal repeat and adjacent cellular sequences. Proc. Natl Acad. Sci. USA, 77, 3307-3311.
40. Wills, J.W. and Craven, R.C. (1991) Form, function and use of retroviral Gag proteins. AIDS, 5, 639-654.
41. Wolff, L. (1997) Contribution of oncogenes and tumor suppressor genes to myeloid leukemia. Biochim. Biophys. Acta, 1332, 67-104.
42. Yap, M.W., Kingsman, S.M. and Kingsman, A.J. (2000) Effects of stoichiometry of retroviral components on virus production. J. Gen. Virol., 81, 2195-2202.
43. Yuan, B., Li, X. and Goff, S.P. (1999) Mutations altering the moloney murine leukemia virus p12 Gag protein affect virion production and early events of the virus life cycle. EMBO J., 18, 4700-4710.