Graves' immunoglobulins activate phospholipase A2 by recognizing specific epitopes on thyrotropin receptor

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 9, 1999, Pages 3283-3292

  Di Cerbo, Alfredo ^a   Di Paola, Rosa ^a   Menzaghi, Claudia ^a   De Filippis, Vito ^a   Tahara, Kazuo ^b   Corda, Daniela ^c   Kohn, Leonard D ^b  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ARACHIDONIC ACID; CYCLIC AMP; EPITOPE; IMMUNOGLOBULIN G; LUTEINIZING HORMONE RECEPTOR; PHOSPHOLIPASE A2; THYROID HORMONE; THYROID STIMULATING IMMUNOGLOBULIN; THYROTROPIN; THYROTROPIN RECEPTOR;

ADOLESCENT; ADULT; AGED; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CELL FUNCTION; CELL GROWTH; CHIMERA; CHO CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; FEMALE; GENETIC TRANSFECTION; GOITER; GRAVES DISEASE; HUMAN; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; RECEPTOR BINDING; THYROID CELL;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0033304961     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.9.3283     Document Type: Article

References (34)

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3. Autoantibodies to the thyrotropin receptor
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5. Subgroups of Graves' patients identified on the basis of the biochemical activities of their immunoglobulins
6. Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: These determinants have no homologous sequence on gonadotropin receptors
7. Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor
8. Presence of heterogeneous thyroid-stimulating antibodies in sera from individual Graves' patients as shown by synthesized thyrotropin receptor peptide application: Evidence showing two independent epitopes and a possible recognition of two epitopic regions by one antibody molecule
9. Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease
10. Discrete characteristics of antibodies raised against thyrotropin receptor-related peptides whose sequences are not conserved in the luteinizing hormone/chorionic gonadotropin receptor
11. A synthetic oligopeptide derived from human thyrotropin receptor sequence binds to Graves' immunoglobulin and inhibits thyroid stimulating antibody activity but lacks interactions with TSH
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14. Antireceptor immunity
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