메뉴 건너뛰기




Volumn 81, Issue 5, 1996, Pages 1758-1767

Epitopes for Thyroid-Stimulating Antibodies in Graves' Sera: A Possible Link of Heterogeneity to Differences in Response to Antithyroid Drug Treatment *

Author keywords

[No Author keywords available]

Indexed keywords

CRICETINAE; CRICETULUS GRISEUS;

EID: 0029937902     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.81.5.8626830     Document Type: Article
Times cited : (64)

References (37)
  • 1
    • 0027015541 scopus 로고
    • Molecular basis for the autoreactivity against thyroid stimulating hormone receptor
    • Kohn LD, Kosugi S, Ban T, et al. 1992 Molecular basis for the autoreactivity against thyroid stimulating hormone receptor. Int Rev Immunol. 9:135-165.
    • (1992) Int Rev Immunol. , vol.9 , pp. 135-165
    • Kohn, L.D.1    Kosugi, S.2    Ban, T.3
  • 3
    • 0003127304 scopus 로고
    • Antireceptor immunity
    • Rayner D, Cooke A, Champion B, eds. Austin/Georgetown: Landes Biomedical
    • Kohn LD, Giuliani C, Montani V, et al. 1995 Antireceptor immunity. In: Rayner D, Cooke A, Champion B, eds. Thyroid immunity. Austin/Georgetown: Landes Biomedical; 115-170.
    • (1995) Thyroid Immunity , pp. 115-170
    • Kohn, L.D.1    Giuliani, C.2    Montani, V.3
  • 4
    • 0026522437 scopus 로고
    • Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid stimulating antibodies and with thyroid stimulating blocking antibodies in idiopathic myxedema: These determinants have no homologous sequence on gonadotropin receptors
    • Kosugi S, Ban T, Akamizu T, Kohn LD. 1992 Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid stimulating antibodies and with thyroid stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors. Mol Endocrinol. 6:168-180.
    • (1992) Mol Endocrinol. , vol.6 , pp. 168-180
    • Kosugi, S.1    Ban, T.2    Akamizu, T.3    Kohn, L.D.4
  • 5
    • 0027532027 scopus 로고
    • Identification of thyroid stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor
    • Kosugi S, Ban T, Kohn LD. 1993 Identification of thyroid stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor. Mol Endocrinol. 7:114-130.
    • (1993) Mol Endocrinol. , vol.7 , pp. 114-130
    • Kosugi, S.1    Ban, T.2    Kohn, L.D.3
  • 6
    • 0025951486 scopus 로고
    • Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or Immunoglobulins from idiopathic myxedema patients
    • Tahara K, Ban T, Minegishi T, Kohn LD. 1991 Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or Immunoglobulins from idiopathic myxedema patients. Biochem Biophys Res Commun. 179:70-77.
    • (1991) Biochem Biophys Res Commun. , vol.179 , pp. 70-77
    • Tahara, K.1    Ban, T.2    Minegishi, T.3    Kohn, L.D.4
  • 7
    • 1542711622 scopus 로고
    • Demonstration of two types of thyroid stimulating antibodies with different epitopes on the human thyrotropin receptor
    • Tahara K, Yamamoto K, Yoshida S. 1992 Demonstration of two types of thyroid stimulating antibodies with different epitopes on the human thyrotropin receptor [Abstract]. Thyroid. 2(Suppl):113.
    • (1992) Thyroid , vol.2 , Issue.SUPPL. , pp. 113
    • Tahara, K.1    Yamamoto, K.2    Yoshida, S.3
  • 8
    • 1542397031 scopus 로고
    • Three types of thyroid stimulating antibodies recognize different epitopes on the human thyrotropin receptor
    • Nagataki S, Mori T, Torizuka K, eds. Amsterdam: Elsevier
    • Tahara K, Yamamoto K, Kohn LD, et al. 1993 Three types of thyroid stimulating antibodies recognize different epitopes on the human thyrotropin receptor. In: Nagataki S, Mori T, Torizuka K, eds. 80 years of Hashimoto's disease. Amsterdam: Elsevier; 675-677.
    • (1993) 80 Years of Hashimoto's Disease , pp. 675-677
    • Tahara, K.1    Yamamoto, K.2    Kohn, L.D.3
  • 9
    • 0028582049 scopus 로고
    • The extracellular domain of the lutropin/choriogonadotropin receptor has distinct sites important for agonist activity and high affinity binding: The agonist site is fully responsive to thyrotropin
    • Hidaka A, Ban T, Panesar NS, Minegishi T, Kohn LD, Tahara K. 1994 The extracellular domain of the lutropin/choriogonadotropin receptor has distinct sites important for agonist activity and high affinity binding: the agonist site is fully responsive to thyrotropin. Thyroid. 4:447-457.
    • (1994) Thyroid , vol.4 , pp. 447-457
    • Hidaka, A.1    Ban, T.2    Panesar, N.S.3    Minegishi, T.4    Kohn, L.D.5    Tahara, K.6
  • 10
    • 1542711619 scopus 로고
    • Clinical determination and/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line FRTL-5. US Patent 4:609,622
    • Kohn LD, Valente WA, Grollman EF, Aloj SM, Vitti P. 1986 Clinical determination and/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line FRTL-5. US Patent 4:609,622.
    • (1986)
    • Kohn, L.D.1    Valente, W.A.2    Grollman, E.F.3    Aloj, S.M.4    Vitti, P.5
  • 12
    • 0021268211 scopus 로고
    • A receptor assay for the measurement of TSH receptor antibodies in unextracted serum
    • Oxf.
    • Southgate K, Creagh F, Teece M, Kingwood C, Smith BR. 1984 A receptor assay for the measurement of TSH receptor antibodies in unextracted serum. Clin Endocrinol (Oxf). 20:539-548.
    • (1984) Clin Endocrinol , vol.20 , pp. 539-548
    • Southgate, K.1    Creagh, F.2    Teece, M.3    Kingwood, C.4    Smith, B.R.5
  • 13
    • 0023266068 scopus 로고
    • A sensitive and practical assay for thyroid-stimulating antibodies using FRTL-5 thyroid cells
    • Copenh.
    • Kasagi K, Konishi J, Iida Y, et al. 1987 A sensitive and practical assay for thyroid-stimulating antibodies using FRTL-5 thyroid cells. Acta Endocrinol (Copenh). 115:30-36.
    • (1987) Acta Endocrinol , vol.115 , pp. 30-36
    • Kasagi, K.1    Konishi, J.2    Iida, Y.3
  • 14
    • 1542711618 scopus 로고
    • Measurements of thyroid growth immunoglobulins in Graves' disease and their relationship with thyroid stimulating antibody and thyrotropin binding inhibitor immunoglobulins
    • Lee M, Koh C-S, Eastman CJ, Nagataki S, eds. Seoul: Korea Publishing
    • Shong YK, Cho BY, Lee HK, Koh C-S, Min HK, Lee M. 1989 Measurements of thyroid growth immunoglobulins in Graves' disease and their relationship with thyroid stimulating antibody and thyrotropin binding inhibitor immunoglobulins. In: Lee M, Koh C-S, Eastman CJ, Nagataki S, eds. Progress in thyroidology 1989. Seoul: Korea Publishing; 25-28.
    • (1989) Progress in Thyroidology 1989 , pp. 25-28
    • Shong, Y.K.1    Cho, B.Y.2    Lee, H.K.3    Koh, C.-S.4    Min, H.K.5    Lee, M.6
  • 15
    • 1542397074 scopus 로고
    • Assay of thyroid stimulating antibodies using cultured rat thyroid cells (FRTL-5) in Graves' disease: Fundamental assessments and clinical significance
    • Cho BY, Shong YK, Lee HK, Koh C-S, Min HK, Lee M. 1988 Assay of thyroid stimulating antibodies using cultured rat thyroid cells (FRTL-5) in Graves' disease: fundamental assessments and clinical significance. Korean J Intern Med. 34:183-195.
    • (1988) Korean J Intern Med. , vol.34 , pp. 183-195
    • Cho, B.Y.1    Shong, Y.K.2    Lee, H.K.3    Koh, C.-S.4    Min, H.K.5    Lee, M.6
  • 16
    • 1542606565 scopus 로고
    • TSH receptor autoantibodies affecting thyroid cell function
    • Pinchera A, Ingbar SH, McKenzie JM, Fenzie GF, eds. New York/London: Plenum Press
    • Fenzie GF, Vitti P, Marcocci C, Chiovato L, Macchia E. 1986 TSH receptor autoantibodies affecting thyroid cell function. In: Pinchera A, Ingbar SH, McKenzie JM, Fenzie GF, eds. Thyroid autoimmunity. New York/London: Plenum Press; 83-90.
    • (1986) Thyroid Autoimmunity , pp. 83-90
    • Fenzie, G.F.1    Vitti, P.2    Marcocci, C.3    Chiovato, L.4    Macchia, E.5
  • 17
    • 1542606567 scopus 로고
    • Studies on antiTSH receptor antibodies in autoimmune thyroid disease
    • Lee M, Koh C-S, Eastman CJ, Nagataki S, eds. Seoul: Korea Publishing
    • Mitani Y, Shigemasa C, Taniguchi S, et al. 1989 Studies on antiTSH receptor antibodies in autoimmune thyroid disease. In: Lee M, Koh C-S, Eastman CJ, Nagataki S, eds. Progress in thyroidology 1989. Seoul: Korea Publishing; 143-146.
    • (1989) Progress in Thyroidology 1989 , pp. 143-146
    • Mitani, Y.1    Shigemasa, C.2    Taniguchi, S.3
  • 18
    • 0020603445 scopus 로고
    • Characterization of the optimal stimulatory effects of Graves' monoclonal and serum immunoglobulin G on adenosine 3′,5′-monophosphate production in FRTL-5 thyroid cells: A potential clinical assay
    • Vitti P, Rotella CM, Valente WA, et al. 1983 Characterization of the optimal stimulatory effects of Graves' monoclonal and serum immunoglobulin G on adenosine 3′,5′-monophosphate production in FRTL-5 thyroid cells: a potential clinical assay. J Clin Endocrinol Metab. 57:782-791.
    • (1983) J Clin Endocrinol Metab. , vol.57 , pp. 782-791
    • Vitti, P.1    Rotella, C.M.2    Valente, W.A.3
  • 19
    • 0027413478 scopus 로고
    • Detection of thyroid stimulating antibody using Chinese hamster ovary cells transfected with cloned human thyrotropin receptor
    • Vitti P, Elisei R, Tonacchera M, et al. 1993 Detection of thyroid stimulating antibody using Chinese hamster ovary cells transfected with cloned human thyrotropin receptor. J Clin Endocrinol Metab. 76:499-503.
    • (1993) J Clin Endocrinol Metab. , vol.76 , pp. 499-503
    • Vitti, P.1    Elisei, R.2    Tonacchera, M.3
  • 20
    • 0008200308 scopus 로고
    • New procedures for detecting Graves' immunoglobulins
    • Walfish P, Wall R, Volpe R, eds. New York: Academic Press
    • Kohn LD, Valente WA, Alvarez FV, et al. 1985 New procedures for detecting Graves' immunoglobulins. In: Walfish P, Wall R, Volpe R, eds. Autoimmunity and the thyroid. New York: Academic Press; 217-247.
    • (1985) Autoimmunity and the Thyroid , pp. 217-247
    • Kohn, L.D.1    Valente, W.A.2    Alvarez, F.V.3
  • 21
    • 0006500345 scopus 로고
    • Monoclonal antibodies to the thyrotropin receptor: Stimulating and blocking antibodies derived from the lymphocytes of patients with Graves' disease
    • Valente WA, Vitti P, Yavin Z, et al. 1982 Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves' disease. Proc Natl Acad Sci USA. 79:6680-6684.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 6680-6684
    • Valente, W.A.1    Vitti, P.2    Yavin, Z.3
  • 22
    • 0022556761 scopus 로고
    • Monoclonal antibody studies defining the organ and properties of autoantibodies in Graves' disease
    • Kohn LD, Alvarez F, Marcocci C, et al. 1986 Monoclonal antibody studies defining the organ and properties of autoantibodies in Graves' disease. Ann NY Acad Sci. 475:157-173.
    • (1986) Ann NY Acad Sci. , vol.475 , pp. 157-173
    • Kohn, L.D.1    Alvarez, F.2    Marcocci, C.3
  • 23
    • 0026464910 scopus 로고
    • Mutation of alanine 623 in the 3rd cytoplasmic loop of the rat TSH receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies
    • Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD. 1992 Mutation of alanine 623 in the 3rd cytoplasmic loop of the rat TSH receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies. J Biol Chem. 267:24153-24156.
    • (1992) J Biol Chem. , vol.267 , pp. 24153-24156
    • Kosugi, S.1    Okajima, F.2    Ban, T.3    Hidaka, A.4    Shenker, A.5    Kohn, L.D.6
  • 24
    • 0027250914 scopus 로고
    • Substitutions of different regions of the 3rd cytoplasmic loop of the TSH receptor have selective effects on constitutive, TSH- and TSH receptor autoantibody-stimulated phosphoinositide and cAMP signal generation
    • Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD. 1993 Substitutions of different regions of the 3rd cytoplasmic loop of the TSH receptor have selective effects on constitutive, TSH- and TSH receptor autoantibody-stimulated phosphoinositide and cAMP signal generation. Mol Endocrinol. 7:1009-1020.
    • (1993) Mol Endocrinol. , vol.7 , pp. 1009-1020
    • Kosugi, S.1    Okajima, F.2    Ban, T.3    Hidaka, A.4    Shenker, A.5    Kohn, L.D.6
  • 25
    • 0028326850 scopus 로고
    • The middle portion of the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation
    • Kosugi S, Kohn LD, Akamizu T, Mori T. 1994 The middle portion of the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation. Mol Endocrinol. 8:498-509.
    • (1994) Mol Endocrinol. , vol.8 , pp. 498-509
    • Kosugi, S.1    Kohn, L.D.2    Akamizu, T.3    Mori, T.4
  • 26
    • 0024323633 scopus 로고
    • Mechanisms by which low salt condition increases sensitivity of thyroid stimulating antibody assay
    • Kosugi S, Mori T, Imura H. 1989 Mechanisms by which low salt condition increases sensitivity of thyroid stimulating antibody assay. Endocrinology. 125:410-417.
    • (1989) Endocrinology , vol.125 , pp. 410-417
    • Kosugi, S.1    Mori, T.2    Imura, H.3
  • 27
    • 0027174708 scopus 로고
    • Immunoglobulin G that interferes with thyroid stimulating antibody measurements can be eliminated specifically by incubation with synthetic peptides corresponding to partial sequences of the human thyrotropin receptor
    • Ueda Y, Sugawa H, Akamizu T, et al. 1993 Immunoglobulin G that interferes with thyroid stimulating antibody measurements can be eliminated specifically by incubation with synthetic peptides corresponding to partial sequences of the human thyrotropin receptor. Thyroid. 3:111-117.
    • (1993) Thyroid , vol.3 , pp. 111-117
    • Ueda, Y.1    Sugawa, H.2    Akamizu, T.3
  • 28
    • 0028961403 scopus 로고
    • Presence of heterogeneous thyroid stimulating antibodies in sera from individual Graves' patients as shown by synthesized TSH-R peptide application
    • Ueda Y, Sugawa H, Akamizu T, et al. 1995 Presence of heterogeneous thyroid stimulating antibodies in sera from individual Graves' patients as shown by synthesized TSH-R peptide application. Eur J Endocrinol. 132:62-68.
    • (1995) Eur J Endocrinol. , vol.132 , pp. 62-68
    • Ueda, Y.1    Sugawa, H.2    Akamizu, T.3
  • 29
    • 0026402135 scopus 로고
    • The extra cellular domain of the TSH receptor has an immunogenic epitope reactive with Graves' sera but unrelated to receptor function as well as epitopes having different roles for high affinity TSH binding and the activity of thyroid stimulating antibodies
    • Kosugi S, Akamizu T, Takai S, Prabhakar B, Kohn LD. 1991 The extra cellular domain of the TSH receptor has an immunogenic epitope reactive with Graves' sera but unrelated to receptor function as well as epitopes having different roles for high affinity TSH binding and the activity of thyroid stimulating antibodies. Thyroid. 1:321-330.
    • (1991) Thyroid. , vol.1 , pp. 321-330
    • Kosugi, S.1    Akamizu, T.2    Takai, S.3    Prabhakar, B.4    Kohn, L.D.5
  • 30
    • 0026002412 scopus 로고
    • Site directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors: Relationship of functional and immunogenic domains
    • Kosugi S, Ban T, Akamizu T, Kohn LD. 1991 Site directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors: relationship of functional and immunogenic domains. J Biol Chem. 266:19413-19418.
    • (1991) J Biol Chem. , vol.266 , pp. 19413-19418
    • Kosugi, S.1    Ban, T.2    Akamizu, T.3    Kohn, L.D.4
  • 31
    • 0025721846 scopus 로고
    • Further characterization of a high-affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients
    • Kosugi S, Ban T, Akamizu T, Kohn LD. 1991 Further characterization of a high-affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients. Biochem Biophys Res Commun. 180:1118-1124.
    • (1991) Biochem Biophys Res Commun. , vol.180 , pp. 1118-1124
    • Kosugi, S.1    Ban, T.2    Akamizu, T.3    Kohn, L.D.4
  • 32
    • 0025939913 scopus 로고
    • Prokaryotic expression of the thyrotropin receptor and identification of the immunogenic region of the protein using synthetic peptides
    • Takai O, Desai RK, Seetharamaiah GS, et al. 1991 Prokaryotic expression of the thyrotropin receptor and identification of the immunogenic region of the protein using synthetic peptides. Biochem Biophys Res Commun. 179:319-326.
    • (1991) Biochem Biophys Res Commun. , vol.179 , pp. 319-326
    • Takai, O.1    Desai, R.K.2    Seetharamaiah, G.S.3
  • 33
    • 0027451585 scopus 로고
    • Dual mechanism of perturbation of thyrotropin mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR derived peptides
    • Desai RK, Dallas JS, Gupta MK, et al. 1993 Dual mechanism of perturbation of thyrotropin mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR derived peptides. J Clin Endocrinol Metab. 77:658-663.
    • (1993) J Clin Endocrinol Metab. , vol.77 , pp. 658-663
    • Desai, R.K.1    Dallas, J.S.2    Gupta, M.K.3
  • 34
    • 0025163684 scopus 로고
    • 2 isomerase-like activities together with altered basal and thyrotropin-responsive thymidine incorporation into DNA
    • 2 isomerase-like activities together with altered basal and thyrotropin-responsive thymidine incorporation into DNA. Endocrinology. 127:1526-1540.
    • (1990) Endocrinology , vol.127 , pp. 1526-1540
    • Bellur, S.1    Tahara, K.2    Saji, M.3    Grollman, E.F.4    Kohn, L.D.5
  • 35
    • 0020564433 scopus 로고
    • Antibodies that promote thyroid growth: A distinct population of thyroid-stimulating autoantibodies
    • Valente WA, Vitti P, Rotella CM, et al. 1983 Antibodies that promote thyroid growth: a distinct population of thyroid-stimulating autoantibodies. N Engl J Med. 309:1028-1034.
    • (1983) N Engl J Med. , vol.309 , pp. 1028-1034
    • Valente, W.A.1    Vitti, P.2    Rotella, C.M.3
  • 36
    • 0026517788 scopus 로고
    • Immunoglobulins from Graves' patients stimulate phospholipase-A2 in FRTL5 thyroid cells
    • Di Cerbo A, Di Girolamo M, Guardabasso V, et al. 1992 Immunoglobulins from Graves' patients stimulate phospholipase-A2 in FRTL5 thyroid cells. J Clin Endocrinol Metab. 74:585-592.
    • (1992) J Clin Endocrinol Metab. , vol.74 , pp. 585-592
    • Di Cerbo, A.1    Di Girolamo, M.2    Guardabasso, V.3
  • 37
    • 0029119115 scopus 로고
    • Subgroups of Graves' patients identified on the basis of the biochemical activities of their immunoglobulins
    • Di Cerbo A, Di Paola R, Bonati M, et al. 1995 Subgroups of Graves' patients identified on the basis of the biochemical activities of their immunoglobulins. J Clin Endocrinol Metab. 80:2785-2790.
    • (1995) J Clin Endocrinol Metab. , vol.80 , pp. 2785-2790
    • Di Cerbo, A.1    Di Paola, R.2    Bonati, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.