Alloantigen presentation by ethylcarbodiimide-treated dendritic cells induces T cell hyporesponsiveness, and prolongs organ graft survival

Clinical Immunology

Volumn 108, Issue 3, 2003, Pages 190-198

  Kaneko, Katsuhiko ^a   Morelli, Adrian E ^a   Wang, Zhiliang ^a   Thomson, Angus W ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Antigen presentation; Dendritic cells; Ethylcarbodiimide; T cells; Transplantation

Indexed keywords

ALLOANTIGEN; ETHYLCARBODIIMIDE; IMIDE; UNCLASSIFIED DRUG;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; BONE MARROW CELL; CLUSTER ANALYSIS; CONTROLLED STUDY; DENDRITIC CELL; GRAFT SURVIVAL; IMMUNOPHENOTYPING; LYMPHOID CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0141788727     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6616(03)00141-4     Document Type: Article

References (33)

1. Steinman R.M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:1991;271-296.
2. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:1998;245-252.
3. Larsen C.P., Morris P.J., Austyn J.M. Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection. J. Exp. Med. 171:1990;307-314.
4. Lechler R.I., Batchelor J.R. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J. Exp. Med. 155:1982;31-41.
5. Austyn J.M., Hankins D.F., Larsen C.P., Morris P.J., Rao A.S., Roake J.A. Isolation and characterization of dendritic cells from mouse heart and kidney. J. Immunol. 152:1994;2401-2410.
6. Woo J., Lu L., Rao A.S., Li Y., Subbotin V., Starzl T.E., Thomson A.W. Isolation, phenotype, and allostimulatory activity of mouse liver dendritic cells. Transplantation. 58:1994;484-491.
7. dim, B7-2) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation. 60:1995;1539-1545.
8. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192:2000;1213-1222.
9. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193:2001;233-238.
10. Rastellini C., Lu L., Ricordi C., Starzl T.E., Rao A.S., Thomson A.W. Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation. 60:1995;1366-1370.
11. -) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation. 62:1996;659-665.
12. Lutz M.B., Suri R.M., Niimi M., Ogilvie A.L., Kukutsch N.A., Rossner S., Schuler G., Austyn J.M. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur. J. Immunol. 30:2000;1813-1822.
13. Hackstein H., Morelli A.E., Thomson A.W. Designer dendritic cells for tolerance induction guided not misguided missiles . Trends Immunol. 22:2001;437-442.
14. Morelli A.E., Hackstein H., Thomson A.W. Potential of tolerogenic dendritic cells for transplantation. Semin. Immunol. 13:2001;323-335.
15. K.L. Carraway, D.E. Koshland, Carbodiimide modification of proteins, in: W. Hirsch, S.N. Timasheff (Eds.), Methods in Enzymology, vol. XXV, Academic Press, New York, pp. 616.
16. Vandenbark A.A., Celnik B., Vainiene M., Miller S.D., Offner H. Myelin antigen-coupled splenocytes suppress experimental autoimmune encephalomyelitis in Lewis rats through a partially reversible anergy mechanism. J. Immunol. 155:1995;5861-5867.
17. Vandenbark A.A., Barnes D., Finn T., Bourdette D.N., Whitham R., Robey I., Kaleeba J., Bebo B.F. Jr., Miller S.D., Offner H., Chou Y.K. Differential susceptibility of human T(h)1 versus T(h) 2 cells to induction of anergy and apoptosis by ECDI/antigen-coupled antigen-presenting cells. Int. Immunol. 12:2000;57-66.
18. Karpus W.J., Peterson J.D., Miller S.D. Anergy in vivo down-regulation of antigen-specific CD4+ Th1 but not Th2 cytokine responses . Int. Immunol. 6:1994;721-730.
19. Jenkins M.K., Schwartz R.H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:1987;302-319.
20. Elliott C., Wang K., Miller S., Melvold R. Ethylcarbodiimide as an agent for induction of specific transplant tolerance. Transplantation. 58:1994;966-968.
21. Morelli A.E., Zahorchak A.F., Larregina A.T., Colvin B.L., Logar A.J., Takayama T., Falo L.D., Thomson A.W. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood. 98:2001;1512-1523.
22. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., Muramatsu S., Steinman R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1992;1693-1702.
23. Morelli A.E., Antonysamy M.A., Takayama T., Hackstein H., Chen Z., Qian S., Zurowski N.B., Thomson A.W. Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells modulation by tacrolimus . J. Immunol. 165:2000;226-237.
24. Grakoui A., Bromley S.K., Sumen C., Davis M.M., Shaw A.S., Allen P.M., Dustin M.L. The immunological synapse a molecular machine controlling T cell activation . Science. 285:1999;221-227.
25. Al-Alwan M.M., Rowden G., Lee T.D., West K.A. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J. Immunol. 166:2001;1452-1456.
26. Miller S.D., Wetzig R.P., Claman H.N. The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells. J. Exp. Med. 149:1979;758-773.
27. Aiello F.B., Longo D.L., Overton R., Takacs L., Durum S.K. A role for cytokines in antigen presentation IL-1 and IL-4 induce accessory functions of antigen-presenting cells . J. Immunol. 144:1990;2572-2581.
28. Kennedy M.K., Tan L.J., Dal Canto M.C., Tuohy V.K., Lu Z.J., Trotter J.L., Miller S.D. Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides. J. Immunol. 144:1990;909-915.
29. P.A. Morel, M. Feili-Hariri, P.T. Coates, A.W. Thomson, Dendritic cells, T cell tolerance and therapy of adverse immune reactions, Clin. Exp. Immunol. (2003) in press.
30. Bonham C.A., Peng L., Liang X., Chen Z., Wang L., Ma L., Hackstein H., Robbins P.D., Thomson A.W., Fung J.J., Qian S., Lu L. Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J. Immunol. 169:2002;3382-3391.
31. O'Rourke R.W., Kang S.M., Lower J.A., Feng S., Ascher N.L., Baekkeskov S., Stock P.G. A dendritic cell line genetically modified to express CTLA4-Ig as a means to prolong islet allograft survival. Transplantation. 69:2000;1440-1446.
32. Ferguson T.A., Herndon J., Elzey B., Griffith T.S., Schoenberger S., Green D.R. Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J. Immunol. 168:2002;5589-5595.
33. Morelli A.E., Larregina A.T., Shufesky W.J., Zahorchak A.F., Logar A.J., Papworth G.D., Wang Z., Watkins S.C., Falo L.D. Jr., Thomson A.W. Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells dependence on complement receptors and effect on cytokine production . Blood. 101:2003;611-620.