Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands

Farmaco

Volumn 58, Issue 9, 2003, Pages 739-748

  De Amici, Marco ^a   Conti, Paola ^a   Fasoli, Ezio ^a   Barocelli, Elisabetta ^b   Ballabeni, Vigilio ^b   Bertoni, Simona ^b   Impicciatore, Mariannina ^b   Roth, Bryan L ^c   Ernsberger, Paul ^c   De Micheli, Carlo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Cloned receptors; Functional assays; Muscarinic ligands; Muscarinic receptor subtypes; Oxotremorine analogues

Indexed keywords

2 [4 (2 METHYL 1H IMIDAZOL 1 YL) 2 BUTYNYL]ISOXAZOLIDIN 3 ONE SESQUIFUMARATE; 2 [4 (2,3 DIMETHYL 1H IMIDAZOLIUM 1 YL) 2 BUTYNYL]ISOXAZOLIDIN 3 ONE IODIDE; 3 [4 (1 PYRROLIDINYL) 1 METHYL 2 BUTYNYL]OXY DELTA 2 ISOXAZOLINE; 3 [4 (2 METHYL 1H IMIDAZOL 1 YL) 2 BUTYNYL]OXY DELTA 2 ISOXAZOLINE SESQUIFUMARATE; 3 [4 (2 METHYL 1H IMIDAZOL 1 YL) 2 BUTYNYL]OXYISOXAZOLE SESQUIFUMARATE; 3 [4 (2,3 DIMETHYL 1H IMIDAZOLIUM 1 YL) 2 BUTYNYL]OXY DELTA 2 ISOXAZOLINE IODIDE; 3 [4 (2,3 DIMETHYL 1H IMIDAZOLIUM 1 YL) 2 BUTYNYL]OXYISOXAZOLE IODIDE; 3 [4 [2 METHYL 3 (4 BROMOBENZYL) 1H IMIDAZOLIUM 1 YL] 2 BUTYNYL]OXYISOXAZOLE BROMIDE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; OXOTREMORINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; NONHUMAN;

EID: 0141788102     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(03)00113-7     Document Type: Article

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