Design, synthesis and antimuscarinic activity of some imidazolium derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 20, 1999, Pages 3003-3008

  Miyachi, Hiroyuki ^a   Kiyota, Hiromi ^a   Segawa, Mitsuru ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; IMIDAZOLE DERIVATIVE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HEART; IN VITRO STUDY; NONHUMAN; SMOOTH MUSCLE; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; IMIDAZOLES; MUSCARINIC ANTAGONISTS; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0033581633     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00517-X     Document Type: Article

References (19)

1. Nathanson, N. M. Annu. Rev. Neurosci. 1987, 10, 195.
2. Hulme, E. C.; Birdsall, N. J. M.; Buckly, N. J. Anna. Rev. Pharmacol. Toxicol. 1990, 30, 633.
3. Mei, L.; Roeske, W. R.; Yamamura, H. I. Life Sci. 1989, 45, 1831
4. Levine, R. R.; Birdsall, N. J. M. Trends. Pharmacol. Sci. 1989, Dec., Supple., VII.
5. Schudt, C.; Boer, R., Eltze, M.; Riedel, R.; Glundler, G.; Birdsall, N. J. M. Eur. J. Pharmacol. 1989, 165, 87, 283, 90.
6. Hammer, R.; Berrie, C. P.; Birdsall, N. J. M.; Burgen, A. S. V.; Hulme, E. C. Nature. 1980, 283, 890.
7. Micheletti, R.; Montagna, E.; Giachetti, A. J. Pharm. Exp. Ther. 1987, 241, 628.
8. Kozikowski, A. P.; Fauq, A. H.; Miller, J. H.; Mckinney, M. Bioorg. Med. Chem. Letters. 1992, 2, 797.
9. Barlow, R.; Berry, K. J.; Glenton, P. A. M.; Nikolaou, N. M.; Soh, K. S. Br. J. Pharmacol. 1976, 58, 613.
10. Lambrecht, G.; Feifel, R.; Forth, B.; Strohmann, C.; Tacke, R.; Mutschler, E. Eur. J. Pharmacol. 1988, 152, 193.
11. Bonner, T. I. Trends Neurosci. 1989, 12, 148.
12. Wess, L. Trends. Pharmacol. Sci. 1993, 14, 308.
13. a) Miyachi, H.; Kiyota, H.; Segawa, M. Bioorg. Med. Chem. Letters. 1998, 8, 1807.
14. b) Miyachi, H.; Kiyota, H.; Segawa, M. Bioorg. Med. Chem. Letters. 1998, 8, 2163.
15. c) Miyachi, H.; Kiyota, H.; Uchiki, H.; Segawa, M. Bioorg. Med. Chem. 1999, 7, 1151.
16. Noronha-Blob, L.; Kachur, J. F. J. Pharmacol. Exp. Ther. 1991, 256, 562.
17. Langtry, H. D.; McTavish, D. Drugs. 1990, 40, 748. Terodiline was recently withdrawn from the market because of its cardiovascular side-effects.
18. Cereda, E.; Ezhara, A.; Quintero M. G.; Bellora, E.; Dubini, E.; Micheletti, R.; Schiavone, A.; Brambilla, A.; Schiavi, G. B.; Donetti, A. J. Med. Chem. 1990, 33, 2108.
19. Carter, J. P.; Noronha-Blob, L.; Audia, V. H.; Dupont, A. C.; McPherson, D. W.; Rzeszotarski, W. J.; Spagnuolo, C. J.; Waid, P. P.; Kaiser, C. J. Med. Chem. 1991, 34, 3065.