Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo

Journal of Clinical Investigation

Volumn 97, Issue 3, 1996, Pages 621-632

  Leroux, Jean Yves ^a,e   Guerassimov, Alexei ^a   Cartman, Annie ^a   Delaunay, Nathalie ^a   Webber, Carolyn ^a   Rosenberg, Lawrence C ^b   Banerjee, Subhashis ^a,d   Poole, A Robin ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b MONTEFIORE MEDICAL CENTER   (United States)

^c SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^d BASF Bioresearch Corporation   (United States)

^e CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Aggrecan; Arthritis; Keratan sulfate; T lymphocytes

Indexed keywords

CD4 ANTIGEN; KERATAN SULFATE; PROTEOGLYCAN;

ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; FEMALE; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; INFLAMMATION; MOUSE; NONHUMAN; POLYARTHRITIS; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; SPONDYLITIS; T LYMPHOCYTE ACTIVATION;

AGGRECANS; ALKYLATION; ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ARTHRITIS; BIOLOGICAL TRANSPORT; CARTILAGE; CATTLE; EPITOPES; EXTRACELLULAR MATRIX PROTEINS; FEMALE; KERATAN SULFATE; LECTINS, C-TYPE; MICE; MICE, INBRED BALB C; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEOGLYCANS; SPONDYLITIS; T-LYMPHOCYTES;

EID: 0030038422     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118458     Document Type: Article

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