Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia

International Journal of Radiation Oncology Biology Physics

Volumn 57, Issue 3, 2003, Pages 813-819

  Ahn, Ki Jung ^a   Lee, Chung K ^a   Choi, Eun Kyung ^b   Griffin, Robert ^a   Song, Chang W ^a   Park, Heon Joo ^a,c,d  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b University of Ulsan College of Medicine   (South Korea)

^c Inha University School of Medicine   (South Korea)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Hyperthermia; Perillyl alcohol; SCK tumor cells

Indexed keywords

ALCOHOLS; CELL CULTURE; CELLS; GROWTH KINETICS; HYPERTHERMIA THERAPY; PATIENT TREATMENT; TUMORS;

CANCER CELLS;

ONCOLOGY;

PERILLYL ALCOHOL;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL; CANCER GROWTH; CANCER SURVIVAL; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; EVALUATION; FEMALE; HEATING; HYPERTHERMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0141727521     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(03)00737-5     Document Type: Article

References (50)

1. Elegbede J.A., Elson C.E., Qureshi A., et al. Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. Carcinogenesis. 5:1984;661-665.
2. Crowell P.L., Gould M.N. Chemoprevention and therapy of cancer by d-limonene. CRC Crit Rev Oncog. 5:1994;1-22.
3. Crowell P.L. Prevention and therapy of cancer by dietary monoterpenes. J Nutr. 129:1999;775S-778S.
4. Belanger J.T. Perillyl alcohol Applications in oncology . Altern Med Rev. 3:1998;448-457.
5. Gould M.N. Cancer chemoprevention and therapy by monoterpenes. Environ Health Perspect. 105:1997;977-979.
6. Clark S.S., Perman S.M., Sahin M.B., et al. Antileukemia activity of perillyl alcohol (POH) Uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest . Leukemia. 16:2002;213-222.
7. 2+ signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. Cell Immunol. 201:2000;6-13.
8. Stark M.J., Burke Y.D., McKinzie J.H., et al. Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol. Cancer Lett. 96:1995;15-21.
9. Stayrook K.R., McKinzie J.H., Burke Y.D., et al. Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells. Carcinogenesis. 18:1997;1655-1658.
10. Unlu S., Mason C.D., Schachter M., et al. Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. J Cardiovasc Pharmacol. 35:2000;341-344.
11. Shin M.B., Perman S.M., Jenkins G., et al. Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl transformed myeloid cell lines. Leukemia. 13:1999;1581-1591.
12. Ariazi E.A., Satomi Y., Ellis M.J., et al. Activation of the transforming growth factor β signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Cancer Res. 59:1999;1917-1928.
13. Reddy B.S., Wang C.X., Samaha H., et al. Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. Cancer Res. 57:1997;420-425.
14. Mills J.J., Chari R.S., Boyer I.J., et al. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res. 55:1995;979-983.
15. Ripple G.H., Gould M.N., Arzoomanian R.Z., et al. Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. Clin Cancer Res. 6:2000;390-396.
16. Hudes G.R., Szarka C.E., Adams A., et al. Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. Clin Cancer Res. 6:2000;3071-3080.
17. Jirtle R.L., Haag J.D., Ariazi E.A., et al. Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor β1 levels during monoterpene-induced regression of mammary tumors. Cancer Res. 53:1993;3849-3852.
18. Grasl-Kraupp B., Rossmanith W., Ruttkay-Nedecky B., et al. Levels of transforming growth factor β and transforming growth factor β receptors in rat liver during growth, regression by apoptosis and neoplasia. Hepatology. 28:1998;717-726.
19. Yu W., Heim K., Qian M., et al. Evidence for role of transforming growth factor-beta in RRR-alpha-tocopheryl succinate-induced apoptosis of human MDA-MB-435 breast cancer cells. Nutr Cancer. 27:1997;267-278.
20. Bassing C.H., Yingling J.M., Howe D.J., et al. A transforming growth factor-β type I receptor that signals to activate gene expression. Science. 263:1994;87-89.
21. Lin H., Wang X.F., Eaton H.G., et al. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell. 68:1992;775-785.
22. Wang X.F., Lin H.Y., Eaton N.G., et al. Expression cloning and characterization of the TGF-β III receptor. Cell. 67:1991;797-805.
23. Wrana J.L., Attisano L., Wieser R., et al. Mechanism of activation of the TGF-β receptor. Nature (Lond). 370:1994;341-347.
24. Lopez-Casillas F., Wrana J.L., Massague J. Betaglycan presents ligand to the TGF-β signaling receptor. Cell. 73:1993;1435-1444.
25. Shi W., Gould M.N. Induction of cytostasis in mammary carcinoma cells treated with anticancer agent perillyl alcohol. Carcinogenesis. 23:2002;131-142.
26. Crowell P.L., Chang R.R., Ren Z., et al. Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. J Biol Chem. 266:1991;17679-17685.
27. Hohl R.J., Lewis K. Differential effects of monoterpenes and lovastatin on RAS processing. J Biol Chem. 270:1995;17508-17512.
28. Crowell P.L., Ren Z., Lin S., et al. Structure activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. Biochem Pharmacol. 47:1994;1405-1415.
29. Schultz S., Buhling F., Ansorge S. Prenylated proteins and lymphocyte proliferation Inhibition by d-limonene and related monoterpenes . Eur J Immunol. 24:1994;301-307.
30. Haag J.D., Gould M.N. Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. Cancer Chemother Pharmacol. 34:1994;477-483.
31. Kato K., Cox A.D., Hisaka M.M., et al. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci U S A. 89:1992;6403-6407.
32. Perone R., Esteve P., Jimenez B., et al. Tumorigenic activity of rho genes from Aplysia californica. Oncogene. 8:1993;1285-1292.
33. Ren Z., Gould M.N. Modulation of small G protein isoprenylation by anticancer monoterpenes in in situ mammary gland epithelial cells. Carcinogenesis. 19:1998;827-832.
34. Ren Z., Gould M.N. Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. Cancer Lett. 76:1994;185-190.
35. Harima Y., Nagata K., Harima K., et al. A randomised clinical trial of radiation therapy versus thermoradiotherapy in stage IIIb cervical carcinoma. Int J Hyperthermia. 17:2001;97-105.
36. Overgaard J., Gonzalez D.G., Hume S.P., et al. Randomized trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. Lancet. 345:1995;540-543.
37. Vernon C.C., Hand J.W., Field S.B., et al. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer Results from five randomized controlled trials . Int J Radiat Oncol Biol Phys. 35:1996;731-744.
38. van der Zee J., Gonzales G.D., van Rhoon G.C., et al. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours A prospective, randomized, multicentre trial. Dutch Hyperthermic Group . Lancet. 355:2000;1119-1125.
39. Song C.W. Effect of local hyperthermia on blood flow and microenvironment A review . Cancer Res. 44:1984;4721s-4730s.
40. Song C.W., Park H.J., Griffin R.J. Improvement of tumor oxygenation by mild hyperthermia Review . Radiat Res. 155:2001;515-528.
41. Urano M., Kuroda M., Nishimura Y. For the clinical application of thermochemotherapy given at mild temperatures. Int J Hyperthermia. 15:1999;79-107.
42. Dahl O., Mella O. Hyperthermia alone or combined with cisplatin in addition to radiotherapy for advanced uterine cervical cancer. Int J Hyperthermia. 18:2002;25-30.
43. Prosnitz L., Jones E. Test the value of hyperthermia in patients with carcinoma of the cervix being treated with concurrent chemotherapy and radiation. Int J Hyperthermia. 18:2002;13-18.
44. Kang M.S., Song C.W., Levitt S.H. Role of vascular function in response of tumors in vivo to hyperthermia. Cancer Res. 40:1980;1130-1135.
45. Takasu T., Lyons J.C., Park H.J., et al. Apoptosis and perturbation of cell cycle progression in an acidic environment after hyperthermia. Cancer Res. 58:1998;2504-2508.
46. Ohtsubo T., Park H.J., Lyons J.C., et al. Effect of acidic environment and p53 on apoptosis induction by hyperthermia. Int J Hyperthermia. 16:2000;481-491.
47. Ohtsubo T., Igawa H., Saito T., et al. Enhancement of cell killing by induction of apoptosis after treatment with mild hyperthermia at 42°C and cisplatin. Radiat Res. 156:2001;103-109.
48. Park H.J., Lyons J.C., Ohtsubo T., et al. Cell cycle progression and apoptosis after irradiation in an acidic environment. Cell Death and Differentiation. 7:2000;729-738.
49. Boon Piet J.M., van der Boon D., Mulder G.J. Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. Toxicol Appl Pharmacol. 167:2000;55-62.
50. Lyons J.C., Ross B.D., Song C.W. Enhancement of hyperthermia effect in vivo by amiloride and DIDS. Int J Radiat Oncol Biol Phys. 25:1993;95-103.