Endotoxemia and hepatic injury in a rodent model of hindlimb unloading

Journal of Applied Physiology

Volumn 95, Issue 4, 2003, Pages 1656-1663

  Rivera, C A ^a   Tcharmtchi, M H ^a   Mendoza, L ^a   Smith, C W ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Endotoxin; Hindlimb suspension; Liver

Indexed keywords

AMINOTRANSFERASE; AMYLOID A PROTEIN; ENDOTOXIN; HAPTOGLOBIN; LIPOPOLYSACCHARIDE BINDING PROTEIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTOXEMIA; HINDLIMB; HISTOPATHOLOGY; IMMOBILIZATION; INFLAMMATION; LIVER INJURY; MALE; MICROGRAVITY; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PORTAL VEIN BLOOD; PRIORITY JOURNAL; RAT; RAT STRAIN;

EID: 0141678346     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00302.2003     Document Type: Article

References (51)

1. Abraham S, Lin CY, Klein HP, Volkmann C, Tigranyan RA, and Vetrova EG. Studies of specific hepatic enzymes involved in the conversion of carbohydrates to lipids in rats exposed to prolonged spaceflight aboard COSMOS 1129. Physiologist 23: S55-S58, 1980.
2. Abraham S, Lin CY, Volkmann C, and Klein HP. Biochemical changes in rat liver after 18.5 days of spaceflight (41566). Proc Soc Exp Biol Med 172: 334-339, 1983.
3. Adachi Y, Moore LE, Bradford BU, Gao W, and Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108: 218-224, 1995.
4. Ahlers I, Tigranyan RA, Ahlersova E, Paulikova E, Datelinka I, Smajda B, Toropila M, and Praslicka M. The effect of space flight upon plasma and tissue lipids in rats. Moscow, USSR: The COSMOS biosatellite program, 1980, p. 247.
5. Amidon GL, DeBrincat GA, and Najib N. Effects of gravity on gastric emptying, intestinal transit, and drug absorption. J Clin Pharmacol 31: 968-973, 1991.
6. Bartold PM, Narayanan AS, and Page RC. Platelet-derived growth factor reduces the inhibitory effects of lipopolysaccharide on gingival fibroblast proliferation. J Periodontal Res 27: 499-505, 1992.
7. Berczi I. Neurohormonal host defense in endotoxin shock. Ann NY Acad Sci 840: 787-802, 1998.
8. Bergmeyer HU. Methods of Enzymatic Analysis. New York: Academic, 1988.
9. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
10. Brunner J, Dipiro JT, and Feldman S. Antipyrine pharmacokinetics in the tail-suspended rat model. J Pharmacol Exp Ther 274: 345-352, 1995.
11. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
12. 2+-sedimented microsomes from rat liver. Biochem Pharmacol 21: 3249-3256, 1972.
13. Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 192: 245-261, 1990.
14. Deever DB, Young RS, Wang S, Bradshaw BA, Miles J, Pettis CR, and Witten ML. Changes in organ perfusion and weight ratios in post-simulated microgravity recovery. Acta Astronaut 50: 445-452, 2002.
15. Feldman S and Brunner J. Small animal model of weightlessness for pharmacokinetic evaluation. J Clin Pharmacol 37: 677-683, 1994.
16. Fleming SD, Rosenkrans CFJ, and Chapes SK. Test of the antiorthostatic suspension model on mice: effects on the inflammatory cell response. Aviat Space Environ Med 61: 327-332, 1990.
17. Frangogiannis NG, Mendoza LH, Lindsey ML, Ballantyne CM, Michael LH, Smith CW, and Entman ML. Interleukin-10 is induced in the reperfused myocardium and may modulate the reaction to injury. J Immunol 165: 2798-2808, 2000.
18. Galleli A, Le Garrec Y, and Chedid L. Increased resistance and depressed delayed-type hypersensitivity to Listeria monocytogenes induced by pretreatment with lipopolysaccharide. Infect Immun 31: 88-94, 1981.
19. Gregory SH, Cousens LP, van Rooijen N, Dopp EA, Carlos TM, and Wing EJ. Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver. J Immunol 168: 308-315, 2002.
20. Gregory SH, Sagnimeni AJ, and Wing EJ. Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils. J Immunol 157: 2514-2520, 1996.
21. Iimuro Y, Frankenberg MV, Arteel GE, Bradford BU, Wall CA, and Thurman RG. Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males. Am J Physiol Gastrointest Liver Physiol 272: G1186-G1194, 1997.
22. Jorgensen JB, Lunde H, Jensen L, Whitehead AS, and Robertsen B. Serum amyloid A transcription in Atlantic salmon (Salmo salar L.) hepatocytes is enhanced by stimulation with macrophage factors, recombinant human IL-1 beta, IL-6 and TNF alpha or bacterial lipopolysaccharide. Dev Comp Immunol 24: 553-563, 2000.
23. Lang CH and Spitzer JA. Glucose kinetics and development of endotoxin tolerance during long-term continuous endotoxin infusion. Metabolism 36: 469-474, 1987.
24. Leach CS. Changes in total body water during spaceflight. J Clin Pharmacol 31: 1001-1006, 1991.
25. Looft-Wilson RC and Gisolfi CV. Rat small mesenteric artery function after hindlimb suspension. J Appl Physiol 88: 1199-1206, 2000.
26. Lopez S, Marco AJ, Prats N, and Czuprynski CJ. Critical role of neutrophils in eliminating Listeria monocytogenes from the central nervous system during experimental murine listeriosis. Infect Immun 68: 4789-4791, 2000.
27. Mackaness GB. Resistance to intracellular infection. J Infect Dis 123: 439-445, 1971.
28. Martin TP, Edgerton VR, and Grindeland RE. Influence of spaceflight on rat skeletal muscle. J Appl Physiol 65: 2318-2325, 1988.
29. Merrill AHJ, Hoel M, Wang E, Mullins RE, Hargrove JL, Jones DP, and Popova IA. Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887 [published erratum appears in FASEB J 4: 2539, 1990]. FASEB J 4: 95-100, 1990.
30. Merrill AHJ, Wang E, LaRocque R, Mullins RE, Morgan ET, Hargrove JL, Bonkovsky HL, and Popova IA. Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044. J Appl Physiol 73: 142S-147S, 1992.
31. Miller ES and Sonnenfeld G. Influence of suspension on the expression of protective immunological memory to murine Listeria monocytogenes infection. J Leukoc Biol 54: 578-583, 1993.
32. Miller ES and Sonnenfeld G. Influence of antiorthostatic suspension on resistance to murine Listeria monocytogenes infection. J Leukoc Biol 55: 371-378, 1994.
33. Milosevic N, Schawalder H, and Maier P. Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes. Eur J Pharmacol 368: 75-87, 1999.
34. Nanji AA, Mendenhall CL, and French SW. Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res 13: 15-19, 1989.
35. Nemeth S, Macho L, Palkovic M, Skottova N, and Tigranyan RA. Metabolic changes in rats subjected to space flight for 18.5 days in the biosatellite COSMOS 936. Adv Space Res 1: 219-224, 1981.
36. Nolan JP. Intestinal endotoxins as mediators of hepatic injury - an idea whose time has come again. Hepatology 10: 887-891, 1989.
37. Peterson TC and Renton KW. Kupffer cell factor mediated depression of hepatic parenchymal cell cytochrome P-450. Biochem Pharmacol 35: 1491-1497, 1986.
38. Qu W, Kauffman FC, and Thurman RG. Food restriction stimulates conjugation of p-nitrophenol in perfused rat liver. Arch Biochem Biophys 319: 451-456, 1995.
39. Rakhmilevich AL. Neutrophils are essential for resolution of primary and secondary infection with Listeria monocytogenes. J Leukoc Biol 57: 827-831, 1995.
40. Rivera CA, Bradford BU, Seabra V, and Thurman RG. Role of endotoxin in the hypermetabolic state after acute ethanol exposure. Am J Physiol Gastrointest Liver Physiol 275: G1252-G1258, 1998.
41. Rogers HW and Unanue ER. Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect Immun 61: 5090-5096, 1993.
42. Sampath R, Kukielka GL, Smith CW, Eskin SG, and McIntire LV. Shear stress mediated changes in the expression of leukocyte adhesion receptors on human umbilical vein endothelial cells in vitro. Ann Biomed Eng 23: 247-256, 1995.
43. Schumann RR, Kirschning CJ, Unbehaun A, Aberle HP, Knope HP, Lamping N, Ulevitch RJ, Herrmann F. The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins. Mol Cell Biol 16: 3490-3503, 1996.
44. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, Mathison JC, Tobias PS, and Ulevitch RJ. Structure and function of lipopolysaccharide binding protein. Science 249: 1429-1431, 1990.
45. Smith JA. Neutrophils, host defense, and inflammation: a double edged sword. J Leukoc Biol 56: 672-686, 1994.
46. Smith SM, Krauhs JM, and Leach CS. Regulation of body fluid volume and electrolyte concentrations in spaceflight. Adv Space Biol Med 6: 123-165, 1997.
47. Tipton CM. Animal models and their importance to human physiological responses in microgravity. Med Sci Sports Exerc 28: S94, 1996.
48. Tipton CM, Overton JM, Joyner MJ, and Hargens AR. Local fluid shifts in humans and rats: comparison of simulation models with actual weightlessness. Physiologist 30: S117-S120, 1987.
49. Wisse E. Ultrastructure and function of Kupffer cells and other sinusoidal cells in the liver. In: Kupffer Cells and Other Liver Sinusoidal Cells, edited by Wisse E and Knook DL. Amsterdam: Elsevier/North-Holland Biomedical, 1977, p. 33-60
50. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, and Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433, 1990.
51. Wronski TJ and Morey-Holton E. Skeletal response to simulated weightlessness: a comparison of suspension techniques. Aviat Space Environ Med 58: 63-68, 1987.