Lymphocyte modulation in a baboon model of immunosenescence

Clinical and Diagnostic Laboratory Immunology

Volumn 10, Issue 5, 2003, Pages 870-875

  Jayashankar, Lakshmi ^a   Brasky, Kathleen M ^a   Ward, John A ^b   Attanasio, Roberta ^a,c  

^a GEORGIA STATE UNIVERSITY   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c BROOKE ARMY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD30 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR; PHYTOHEMAGGLUTININ; VACCINE;

AGE; AGING; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BABOON; FEMALE; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; LIFESPAN; LYMPHOCYTE; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

AGING; ANIMALS; ANTIGENS, CD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNOGLOBULINS; IMMUNOPHENOTYPING; LYMPHOCYTES; MALE; PAPIO;

EID: 0141675192     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.10.5.870-875.2003     Document Type: Article

References (43)

1. Aspinall, R., and D. Andrew. 2000. Thymic involution in aging. J. Clin. Immunol. 20:250-256.
2. Attanasio, R., K. M. Brasky, S. H. Robbins, L. Jayashankar, R. J. Nash, and T. M. Butler. 2001. Age-related autoantibody production in a nonhuman primate model. Clin. Exp. Immunol. 123:361-365.
3. Attanasio, R., L. Jayashankar, C. N Engleman, and F. Scinicariello. 2002. Baboon immunoglobulin constant region heavy chains: identification of four IGHG genes. Immunogenetics 54:556-561.
4. Boothby, M., A. L. Mora, and L. M. Stephenson. 2001. Lymphokine-dependent proliferation of T-lymphoid cells: regulated responsiveness and role in vivo. Crit. Rev. Immunol. 21:487-522.
5. Bot, A., M. Shearer, S. Bot, M. Avriette, A. Garcia-Sastre, G. White, C. Woods, R. Kennedy, and C. Bona. 2001. Induction of immunological memory in baboons primed with DNA vaccine as neonates. Vaccine 28:1960-1967.
6. Boucher, N., T. Dufeu-Duchesne, E. Vicaut, D. Farge, R. B. Effros, and F. Schachter. 1998. CD28 expression in T cell aging and human longevity. Exp. Gerontol. 33:267-282.
7. Douziech, N., I. Seres, A. Larbi, E. Szikszay, P. M. Roy, M. Arcand, G. Dupuis, and T. Fulop, Jr. 2002. Modulation of human lymphocyte proliferative response with aging. Exp. Gerontol. 37:369-387.
8. Effros, R. B. 1997. Loss of CD28 expression on T lymphocytes: a marker of replicative senescence. Dev. Comp. Immunol. 21:471-478.
9. Effros, R. B. 2000. Costimulatory mechanisms in the elderly. Vaccine 18: 1661-1665.
10. Engwerda, C. R., B. S. Fox, and B. S. Handwerger. 1996. Cytokine production by T lymphocytes from young and aged mice. J. Immunol. 156:3621-3630.
11. Fagarasan, S., and T. Honjo. 2000. T-independent immune response: new aspects of B cell biology. Science 290:89-92.
12. Fahey, J. L., J. F. Schnelle, J. Boscardin, J. K. Thomas, M. E. Gorre, N. Aziz, H. Sadeghi, and P. Nishanian. 2000. Distinct categories of immunologic changes in frail elderly. Mech. Ageing Dev. 115:1-20.
13. Farah, I. O., and M. Nyindo. 1996. Schistosoma mansoni induces in the Kenyan baboon a novel intestinal pathology that is manifestly modulated by an irradiated cercarial vaccine. J. Parasitol. 82:601-607.
14. Gerli, R., D. Monti, O. Bistoni, A. M. Mazzone, G. Peri, A. Cossarizza, M. Di Gioacchino, M. E. Cesarotti, A. Doni, A. Mantovani, C. Franceschi, and R. Paganelli. 2000. Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. Mech. Ageing Dev. 121:37-46.
15. 197 conjugate vaccine. Infect. Immun. 65: 1710-1715.
16. Hainsey, B. M., G. B. Hubbard, M. M. Leland, and K. M. Brasky. 1993. Clinical parameters of the normal baboon (Papio species) and chimpanzees (Pan troglodytes). Lab. Anim. Sci. 43:236-243.
17. Harewood, W. J., A. Gillin, A. Hennessy, J. Armistead, J. S. Horvath, and D. Tiller. 1999. Biochemistry amd hematology values for the baboon (Papio hamadryas): the effects of sex, growth, development and age. J. Med. Primatol. 28:19-31.
18. Hobbs, M. V., and D. N. Ernst. 1997. T cell differentiation and cytokine expression in late life. Dev. Comp. Immunol. 21:461-470.
19. Hu, A., D. Ehleiter, R. Schwab, C. Russo, P. Szabo, and M. E. Weksler. 1993. Effects of age on the expressed B cell repertoire: role of B cell subsets. Int. Immunol. 5:1035-1039.
20. Krampera, M., F. Vinante, L. Tavecchia, L. Morosato, M. Chilosi, S. Romagnani, M. E. Zanolin, and G. Pizzolo. 1999. Progressive polarization towards a T helper/cytotoxic type-1 cytokine pattern during age-dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration. Clin. Exp. Immunol. 117:291-297.
21. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233-258.
22. Locher, C. P., S. A. Witt, B. G. Herndier, K. Tenner-Racz, P. Racz, and J. A. Levy. 2001. Baboons as an animal model for human immunodeficiency virus pathogenesis and vaccine development. Immunol. Rev. 183:127-140.
23. Locher, C. P., S. A. Witt, B. G. Herndier, N. W. Abbey, K. Tenner-Racz, P. Racz, N. B. Kiviat, K. K. Murthy, K. Brasky, M. Leland, and J. A. Levy. 2003. Increased virus replication and virulence after serial passage of human immunodeficiency virus type 2 in baboons. J. Virol. 77:77-83.
24. Locher, C. P., S. Fujimura, K. K. Murthy, K. Brasky, M. Leland, and J. A. Levy. 2003. Expression patterns of phenotypic markers on lymphocytes from human immunodeficiency virus type 2-infected baboons. AIDS Res. Hum. Retrovir. 19:31-40.
25. Martin, L. J., M. C. Mahaney, A. M. Bronikowski, K. Dee Carey, B. Dyke, and A. G. Commuzie. 2002. Lifespan in captive baboons is heritable. Mech. Ageing Dev. 123:1461-1467.
26. Miller, R. A. 1996. The aging immune system. Primer and prospectus. Science 273:70-74.
27. Miller, R. A. 1999. Aging and immune function, p. 947-966. In W. P. Paul (ed.), Fundamental immunology. Philadelphia, Pa.
28. Miller, R. A. 2000. Effects of aging of T lymphocyte activation. Vaccine 18:1654-1660.
29. Morris, J. C., and T. A. Waldmann. 2000. Advances in interleukin 2 receptor targeted treatment. Ann. Rheum. Dis. 59(Suppl. 1):i109-i114.
30. Nagel, J. E., R. K. Chopra, F. J. Chrest, M. T. McCoy, E. L. Schneider, N. J. Holbrook, and W. H. Adler. 1988. Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Investig. 81:1096-1102.
31. Paoletti, L. C., J. Pinel, R. C. Kennedy, and D. L. Kasper. 2000. Maternal antibody transfer in baboons and mice vaccinated with a group B streptococcal polysaccharide conjugate. J. Infect. Dis. 181:653-658.
32. Pehler, K., K. M. Brasky, T. M. Butler, and R. Attanasio. 2000. Mycobacterium tuberculosis-secreted protein antigens: immunogenicity in baboons. J. Clin. Immunol. 20:306-316.
33. Rea, I. M., M. Stewart, P. Campbell, H. D. Alexander, A. D. Crockard, and T. C. Morris. 1996. Changes in lymphocyte subsets, interleukin 2, and soluble interleukin 2 receptor in old and very old age. Gerontology 46:69-78.
34. Rudy, B. J., C. M. Wilson, S. Durako, A. B. Moscicki, L. Muenz, and S. D. Douglas. 2002. Peripheral blood lymphocyte subsets in adolescents: a longitudinal analysis from the REACH project. Clin. Diagn. Lab. Immunol. 9:959-965.
35. Scinicariello, F., L. Jayashankar, and R. Attanasio. 2002. Baboon immunoglobulin variable region heavy chains: identification of genes homologous to members of the human IGHV1-IGHV7 subgroups. Immunogenetics 53:815-820.
36. Shearer, M. H., A. H. Lucas, P. W. Anderson, K. D. Carey, H. B. Jenson, T. C. Chanh, J. R. Stanley, and R. C. Kennedy. 1997. The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines. Infect. Immun. 65:3267-3270.
37. Sindermann, J., A. Kruse, H. J. Frercks, R. M. Schutz, and H. Kirchner. 1993. Investigation of the lymphokine system in elderly individuals. Mech. Ageing Dev. 70:149-159.
38. Wang, C. Y., M. Shen, G. Tam, X. D. Fang, J. Ye, F. Shen, A. M. Walfield, J. J. Wang, M. L. Li, X. M. Li, M. Salas, M. H. Shearer, R. C. Kennedy, and C. V. Hanson. 2002. Synthetic AIDS vaccine by targeting HIV receptor. Vaccine 21:89-97.
39. Watts, A. M., J. R. Stanley, M. H. Shearer, P. S. Hefty, and R. C. Kennedy. 1999. Fetal immunization of baboons induces a fetal-specific antibody response. Nat. Med. 5:427-430.
40. Weksler, M., and P., Szabo. 2000. The effect of age on the B-cell repertoire. J. Clin. Immunol. 20:240-249.
41. Wick, G., P. Jansen-Durr, P. Berger, I. Blasko, and B. Grubeck-Loebenstein. 2000. Diseases of aging. Vaccine 18:1567-1583.
42. Xu, X., I. Beckman, K. Dimopoulost, M. Ahern, and J. Bradley. 1992. Agerelated changes in the expression of T cell activation antigen following phytohaemagglutinin stimulation. Exp. Clin. Immunogenet. 9:203-211.
43. Xu, X., I. Beckman, M. Ahern, and J. Bradley. 1993. A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry. Immunol. Cell Biol. 71:549-557.