A generic model for 11C labelled radiopharmaceuticals for imaging receptors in the human brain

Radiation Protection Dosimetry

Volumn 105, Issue 1-4, 2003, Pages 587-591

  Nosslin, B ^a   Johansson, L ^b   Leide Svegborn, S ^a   Liniecki, J ^c   Mattsson, S ^a   Taylor, D M ^d  

^a LUND UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c MEDICAL UNIVERSITY OF LODZ   (Poland)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; BRAIN RECEPTOR; CARBON 11; CARFENTANIL; EPIDEPRIDE; FLUMAZENIL; ISOREMOXIPRIDE; METHYLPHENIDATE; OMEWAY 100634; OPIATE RECEPTOR AFFECTING AGENT; PIPERIDINE DERIVATIVE; RACLOPRIDE; RADIOPHARMACEUTICAL AGENT; SEROTONIN RECEPTOR AFFECTING AGENT; SPIPERONE; UNCLASSIFIED DRUG; CARBON; DIAGNOSTIC AGENT; MEMBRANE PROTEIN;

ARTICLE; BLADDER; BRAIN TISSUE; CONTROLLED STUDY; DOSIMETRY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RETENTION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; DRUG UPTAKE; GALLBLADDER; HUMAN; IMAGE ANALYSIS; KIDNEY; MODEL; NONHUMAN; OVARY; POSITRON EMISSION TOMOGRAPHY; PREDICTION; RADIATION DOSE DISTRIBUTION; TISSUE DISTRIBUTION; URINARY EXCRETION; BIOLOGICAL MODEL; BRAIN; BRAIN MAPPING; COMPARATIVE STUDY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER SIMULATION; EVALUATION; METABOLISM; METHODOLOGY; NERVE CELL; RADIATION DOSE; RADIOMETRY; SCINTISCANNING; VALIDATION STUDY;

BRAIN; BRAIN MAPPING; CARBON RADIOISOTOPES; COMPUTER SIMULATION; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; NEURONS; RADIATION DOSAGE; RADIOMETRY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0141675104     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.rpd.a006308     Document Type: Article

References (26)

1. Iyo, M., Namba, H., Fukushi, K., Shinotoh, H., Nagatsuka, S., Suhara, T., Sudo, Y., Suzuki, K. and Irie, T. Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease. Lancet, 349, 1805-1809 (1997).
2. 11C]methylpiperidin-4-yl acetate without arterial blood sampling: methodology of shape analysis and its diagnostic power for Alzheimer's disease. J. Cereb. Blood Flow Metab. 21, 295-306 (2001).
3. 11C]NMPB), a muscarinic acetylcholine receptor antagonist. Nucl. Med. Biol. 22, 13-17 (1995).
4. 11C-Ro 15 3890: PET study in human volunteers. Human Psychopharmacol. 4, 215-220 (1989).
5. 11C]RO 15 1788 to central type benzodiazepine receptors in human brain: quantitative evaluation by PET. J. Cereb. Blood Flow Metab. 8, 304-313 (1988).
6. Verhoeff, N. P. L. G., Sokote, E. B., Hengst, D., Stubbs, J. B. and van Royen, E. A. Dosimetry of iodine-123 iomazenil in humans. J. Nucl. Med. 20, 580-584 (1993).
7. Westera, G., Buck, A., Burger, C., Leenders, K. L., von Schultness, G. K. and Schubiger, A. P. Carbon-11 and iodine-123 labelled iomazenil: a direct PET-SPECT comparison. Eur. J. Nucl. Med. 23, 5-12 (1996).
8. Farde, L., Hall, H., Ehrin, E and Sedvall, G. Quantitative analysis of D2 dopamine receptor binding in the living human brain. Science 231, 258-261 (1986).
9. 11C-raclopride-PET investigation. (Abstract 1038). J. Nucl. Med. 42(Suppl.), 246P.
10. 2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients. Psychopharmacol. 133, 394-404 (1997).
11. 11C]FLB 457 binding to extrastriatal dopamine receptors in the human brain. J. Cerebral Blood Flow Metab. 19, 1164-1173 (1999).
12. Votaw, J. R., Ansari, M. S., Scott Mason, N., Schmidt, D., de Paulis, T., Holburn, G., Clanton, J. A., Votlaw, D. B., Manning, R. G. and Kessler, R. M. Dosimetry of iodine-123-epidepride: a dopamine D2 receptor ligand. J. Nucl. Med. 36, 1316-1321 (1995).
13. ICRP. Radiation dose to patients from radiopharmaceuticals. Publication 53. Ann. ICRP 18(1-4), 53 (1953).
14. 11C]Methylspiperone, a ligand binding to dopamine receptors: radiochemical synthesis and biodistribution studies in mice. J. Nucl. Med. 25, 1222-1227 (1984).
15. Volkow, N. D., Ding, Y.-S., Fowler, J. S., Wang, G.-J., Logan, J., Gatley, S. J., Schlyer, D. J. and Pappas, N. A new PET ligand for the dopamine transporter: studies in human brain. J. Nucl. Med., 36, 2162-2168 (1995).
16. 11C]carfentanil binding to opiate receptors in humans by positron emission tomography. J. Cereb. Blood Flow Metab. 10, 484-492 (1990).
17. Kim, S., Wagner, H. N. Jr, Villemagne, V. L., Kao, P.-F., Dannals, R. F., Ravert, H. T., Joh, T., Dixon, R. B. and Civelik, A. C. Longer occupancy of opoid receptors by nalmefene compared to naloxane as measured in vivo by a dual detector system. J. Nucl. Med. 38, 1726-1731 (1997).
18. McClain, D. A. and Hug, C. C., Jr. Intravenous fentanyl kinetics. Clin. Pharmacol. Ther. 28, 106-114 (1980).
19. 11C]WAY-100635. Med. Chem. Res. 5, 208-227 (1995).
20. 1A receptors: radiosyntheses, and in vitro and in vivo evaluation. Nucl. Med. Biol. 25, 769-776 (1998).
21. 11C]WAY-100635, in monkey and human plasma by HPLC: comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET. Nucl. Med. Biol. 23, 627-634 (1996).
22. 1A receptors with PET: WAY-100635 and analogues. Nucl. Med. Biol. 27, 463-466 (2000).
23. 11C]McN5652: a serotonin transporter radioligand. J. Cereb. Blood Flow Metab. 19, 967-981 (1999).
24. 11C]DASB. Eur. J. Nucl. Med. 27, 1719-1722 (2000).
25. 11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography. Nucl. Med. Biol. 29, 509-515 (2002).
26. ICRP. Radiation dose to patients from radiopharmaceuticals: addendum to ICRP Publication 53. Publication 80. Ann. ICRP 28(3) (1998).