Detection of ligands from a dynamic combinatorial library by X-ray crystallography

Angewandte Chemie - International Edition

Volumn 42, Issue 37, 2003, Pages 4479-4482

  Congreve, Miles S ^a   Davis, Deborah J ^a   Devine, Lindsay ^a   Granata, Cesare ^a   O'Reilly, Marc ^a   Wyatt, Paul G ^a   Jhoti, Harren ^a  

^a ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

Analytical methods; Combinatorial chemistry; Medicinal chemistry; Proteins; X ray diffraction

Indexed keywords

CRYSTALS; ENZYMES; X RAY CRYSTALLOGRAPHY;

LIGANDS;

COMPLEXATION;

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; HYDRAZINE DERIVATIVE; ISATIN DERIVATIVE; LIGAND; OXINDOLE;

ARTICLE; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; CRYSTALLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; DYNAMIC COMBINATORIAL LIBRARY; ENZYME BINDING; MOLECULAR RECOGNITION; PROTEIN BINDING; REACTION ANALYSIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BIOLOGICAL ASSAY; CDC2-CDC28 KINASES; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141670350     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351951     Document Type: Article

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