Achromatopsia-associated Mutation in the Human Cone Photoreceptor Cyclic Nucleotide-gated Channel CNGB3 Subunit Alters the Ligand Sensitivity and Pore Properties of Heteromeric Channels

Journal of Biological Chemistry

Volumn 278, Issue 36, 2003, Pages 34533-34540

  Peng, Changhong ^a   Rich, Elizabeth D ^a   Varnum, Michael D ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; FLUORESCENCE; GENES; HUMAN ENGINEERING; ISOMERS; MUTAGENESIS; PATHOLOGY; PATIENT TREATMENT;

GENE ENCODING; HETEROMERIC CHANNELS;

BIOCHEMISTRY;

CYCLIC GMP; CYCLIC NUCLEOTIDE; DILTIAZEM; GREEN FLUORESCENT PROTEIN; PROTEIN; PROTEIN CNGB3; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CNGB3 PROTEIN, HUMAN; CYCLIC AMP; HYBRID PROTEIN; ION CHANNEL; LIGAND; MESSENGER RNA; PHOTOPROTEIN; POTASSIUM; RECOMBINANT PROTEIN;

ARTICLE; COLOR BLINDNESS; GENE; GENE MUTATION; HUMAN; HUMAN CELL; NULL CELL; PATHOGENICITY; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; RECEPTOR AFFINITY; RETINA CONE; S435F GENE; XENOPUS; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE; CHEMISTRY; COLOR VISION DEFECT; CONFOCAL MICROSCOPY; DIMERIZATION; DOSE RESPONSE; ELECTROPHYSIOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; OOCYTE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CELL MEMBRANE; COLOR VISION DEFECTS; CONES (RETINA); CYCLIC AMP; CYCLIC GMP; DILTIAZEM; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GREEN FLUORESCENT PROTEINS; HUMANS; ION CHANNELS; KINETICS; LIGANDS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PHOTORECEPTORS; POTASSIUM; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS;

EID: 0141668884     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305102200     Document Type: Article

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