Use of inhaler devices in pediatric asthma

Pediatric Drugs

Volumn 5, Issue 9, 2003, Pages 629-638

  De Benedictis, Fernando Maria ^a   Selvaggio, David ^a  

^a Salesi Children's Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; CORTICOSTEROID;

AEROSOL; ASTHMA; CLINICAL TRIAL; DRUG DELIVERY SYSTEM; EXHALATION; HUMAN; METERED DOSE INHALER; NEBULIZATION; NEBULIZER; POWDER INHALER; PRIORITY JOURNAL; REVIEW;

ADMINISTRATION, INHALATION; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; HUMANS; METERED DOSE INHALERS; NEBULIZERS AND VAPORIZERS; POWDERS;

EID: 0141649476     PISSN: 11745878     EISSN: None     Source Type: Journal    
DOI: 10.2165/00148581-200305090-00005     Document Type: Review

References (74)

1. Canny GJ, Levison H. Aerosols: therapeutic use and delivery in childhood asthma. Ann Allergy 1998; 60: 11-9
2. Newman SP, Clark SW. Therapeutic aerosol: physical and practical considerations. Thorax 1983; 38: 881-6
3. Barry PW, O'Callaghan C. Nebuliser therapy in childhood. Thorax 1997; 52: S78-88
4. Janssens HM, De Jongste JC, Hop WC, et al. Extra-fine particles improve lung delivery of inhaled steroids in infants: a study in an upper airway model. Chest 2003; 123 (6): 2083-8
5. Janssens HM, de Jongste JC, Fokkens WJ, et al. The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infants. J Aerosol Med 2001; 14 (4): 433-41
6. Stocks J, Hislop AA. Structure and function of the respiratory system: developmental aspects and their relevance to aerosol therapy. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Lung biology in health and disease: drug delivery to the lung. New York: Marcel Dekker, 2002: 47-89
7. Biggart E, Bush A. Antiasthmatic drug delivery in children. Pediatr Drugs 2002; 4: 85-93
8. O'Callaghan C, Barry PW. The science of nebulised drug delivery. Thorax 1997; 52: S31-44
9. Smaldone GC, LeSoeuef PN. Nebulization: the device and clinical consideration. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Lung biology in health and disease: drug delivery to the lung. New York: Marcel Dekker, 2002: 269-302
10. Denyer J. Adaptive aerosol delivery in practice. Eur Respir Rev 1997; 51: 388-9
11. McCallion ON, Taylor KM, Thomas M, et al. Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers. Pharm Res 1995; 12: 1682-8
12. Wood JA, Wilson RS, Bray C. Changes in salbutamol concentration in the reservoir solution of a jet nebulizer. Br J Dis Chest 1986; 80: 164-9
13. O'Callaghan C. Particle size of beclomethasone dipropionate produced by two nebulisers and two spacing devices. Thorax 1990; 45: 109-11
14. Nikander K, Turpeinen M, Wollmer P. The conventional ultrasonic nebulizer proved inefficient in nebulizing a suspension. J Aerosol Med 1999; 12: 47-53
15. Collis GG, Cole CH, Le Souef PN. Dilution of nebulised aerosols by air entrainment in children. Lancet 1990; 336: 341-3
16. Iles R, Lister P, Edmunds AT. Crying significantly reduces absorption of aerosolized drug in infants. Arch Dis Child 1999; 81: 163-5
17. Everard ML, Hardy JG, Milner AD. Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation. Thorax 1993; 48: 1045-6
18. Everard ML, Clark AR, Milner AD. Drug delivery from jet nebulisers. Arch Dis Child 1992; 67: 586-91
19. National Heart Lung and Blood Institute. Global strategy for asthma management and prevention. Bethesda (MD): National Institutes of Health, 2002 (Rev. ed.)
20. Ilangovan P, Pedersen S, Godfrey S, et al. Treatment of severe steroid dependent pre-school asthma with nebulised budesonide suspension. Arch Dis Child 1993; 68: 356-9
21. The Nebuliser Project Group of the British Thoracic Society Standard of Care Committee. Current best practice for nebuliser treatment. Thorax 1997; 52: S4-S24
22. ERS Task Force. European Respiratory Society guidelines on the use of nebulizers. Eur Respir J 2001; 18: 228-42
23. O'Callaghan C, Wright P. The metered-dose inhaler. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Lung biology in health and disease: drug delivery to the lung. New York: Marcel Dekker, 2002: 337-70
24. Goldin JG, Tashkin DP, Kleerup EC, et al. Comparative effect of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways assessment with functional helical thin-section computed tomography. J Allergy Clin Immunol 1999; 104: S258-67
25. Melchor R, Biddiscombe MF, Mak VHF, et al. Lung deposition patterns of directly labeled salbutamol in normal subjects and in patients with reversible airflow obstruction. Thorax 1993; 48: 506-11
26. Schultz RK. Drug delivery characteristics of metered-dose inhalers. J Allergy Clin Immunol 1995; 96: 284-7
27. Everard ML, Devadason SG, Summers QA, et al. Factors affecting total and "respirable" dose delivered by a salbutamol metered does inhaler. Thorax 1995; 50: 746-9
28. Pedersen S. Inhalers and nebulizers: which to choose and why. Respir Med 1996; 90: 69-77
29. McFadden ER. Improper patient techniques with metered dose inhalers: clinical consequences and solutions to misuse. J Allergy Clin Immunol 1995; 96: 273-83
30. O'Callaghan C, Everard ML, Bush A, et al. Salbutamol dry powder inhaler: efficacy, tolerability, and acceptability study. Pediatr Pulmonol 2002; 33: 189-93
31. Anderson PJ. Delivery options and devices for aerosolized therapeutics. Chest 2001; 120: S89-93
32. Ruggins NR, Milner AD, Swarbrick A. An assessment of a new breath actuated inhaler device in acutely wheezy children. Arch Dis Child 1993; 68: 477-80
33. Borgström L, Bisgaard H, O'Callaghan C, et al. Dry-powder inhalers. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Lung biology in health and disease: drug delivery to the lung. New York: Marcel Dekker, 2002: 421-48
34. Svartengren K, Lindestad P, Svartengren M, et al. Added external resistance reduces oropharyngeal deposition and increases lung deposition of aerosol particles in asthmatics. Am J Respir Crit Care Med 1995; 152: 32-7
35. Bisgaard H, Klug B, Sumby B, et al. Fine particle mass from the Diskus inhaler and Turbuhaler inhaler in children with asthma. Eur Respir J 1998; 11: 1111-5
36. Nielsen K, Auk IL, Bojsen K, et al. Clinical effect of Diskus™ dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children. Eur Respir J 1998; 11: 350-4
37. Borgström L. On the use of dry powder inhalers in situations perceived as constrained. J Aerosol Med 2001; 14: 281-7
38. Bisgaard H, Anhøj J, Wildhaber JH. Spacer devices. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Lung biology in health and disease: drug deliyery to the lung. New York: Marcel Dekker, 2002: 389-420
39. Thorsson L, Edsbacker S. Lung deposition of budesonide from a pressurized metered-dose inhaler attached to a spacer. Eur Respir J 1998; 12: 1340-5
40. Barry PW, O'Callaghan C. Multiple actuations of salbutamol MDI into a spacer device reduce the amount of drug recovered in the respirable range. Eur Respir J 1994; 7: 1707-9
41. Barry PW, O'Callaghan C. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler. Br J Clin Pharmacol 1995; 40: 76-8
42. Wildhaber JH, Devadason SG, Eber E, et al. Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants. Thorax 1996; 51: 985-8
43. Rau JL, Restrepo RD, Deshpande V. Inhalation of single vs multiple metered-dose bronchodilator actuations from reservoir devices. Chest 1996; 109: 969-974
44. Barry PW, Robertson CF, O'Callaghan C. Optimum use of a spacer device. Arch Dis Child 1993; 69: 693-4
45. Berlinski A, Waldrep JC. Metering performance of several metered-dose inhalers with different spacers/holding chamber. J Aerosol Med 2001; 14: 427-32
46. Clark DJ, Lipworth BJ. Effects of multiple actuations, delayed inhalation and antistatic treatment on lung bioavailability of salbutamol via a spacer device. Thorax 1996; 51: 835-40
47. Pierart F, Wildhaber JH, Vrancken I, et al. Washing plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery. Eur Respir J 1999; 13: 673-8
48. Wildhaber JH, Devadason SG, Hayden MJ. Electrostatic charge on a plastic spacer device influences the delivery of salbutamol. Eur Respir J 1999; 9: 1943-6
49. Wildhaber JH, Janssens HM, Pierart P, et al. High-percentage lung delivery in children from detergent-treated spacers. Pediatr Pulmonol 2000; 29: 389-93
50. Janssens HM, Heijnen EMEW, de Jong VM, et al. Aerosol delivery from spacers in wheezy infants: a daily life study. Eur Respir J 2000; 16: 850-6
51. Anhøj J, Bisgaard H, Lipworth BJ. Effect of electrostatic charge in plastic spacer on the lung delivery of HFA-salbutamol in children. Br J Clin Pharmacol 1999; 47: 333-6
52. Kenyon CJ, Thorsson L, Borgstrom L, et al. The effect of static charge in spacer devices on glucocorticosteroid aerosol deposition in asthmatic patients. Eur Respir J 1998; 11: 606-10
53. Berg E, Madsen J, Bisgaaard H. In vitro performance of three combinations of spacer and pressurized metered dose inhalers for treatment of children. Eur Respir J 1998; 12: 472-6
54. Bisgaard H. A metal aerosol holding chamber devised for young children with asthma. Eur Respir J 1995; 8: 856-60
55. Bisgaard H, Anhøj J, Klug B, et al. A non-electrostatic spacer for aerosol delivery. Arch Dis Child 1995; 73: 226-30
56. Wildhaber JH, Devadason SG, Hayden MJ, et al. Aerosol delivery to wheezy infants: a comparison between a nebulizer and two small volume spacers. Pediatr Pulmonol 1997; 23: 212-6
57. Wildhaber JH, Dore ND, Wilson JM, et al. Inhalation therapy in asthma - nebulizer or pressurized metered-dose inhaler with holding chamber: in vivo comparison of lung deposition in children. J Pediatr 1999; 135: 28-33
58. Tal A, Golan H, Grauer N, et al. Deposition pattern of radiolabeled salbutamol inhaled from a metered dose inhaler by means of a spacer with mask in young children with airway obstruction. J Pediatr 1996; 128: 479-84
59. Janssens HM, Devadason SG, Hop WCJ, et al. Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. Eur Respir J 1999; 13: 787-91
60. Barry PW, O'Callaghan C. Inhalation drug delivery from seven different spacer devices. Thorax 1996; 51: 835-40
61. Mitchell JP, Nagel MW. In vitro performance testing of three small volume holding chambers under conditions that correspond with use by infants and small children. J Aerosol Med 1997; 10: 341-9
62. Zac M, Madsen J, Berg E, et al. A mathematical model of aerosol holding chambers. J Aerosol Med 1999; 12: 187-96
63. Lowenthal D, Kattan M. Facemasks versus mouthpiece for aerosol treatment in asthmatic children. Pediatr Pulmonol 1992; 14: 192-6
64. Everard ML, Clark AR, Milner AD. Drug delivery from holding chambers with attached face mask. Arch Dis Child 1992; 67: 580-5
65. Zar HJ, Weinberg EG, Binns HJ, et al. Lung deposition of aerosol: a comparison of different spacers. Arch Dis Child 2000; 82: 495-8
66. Powell CVE, Maskell GR, Murks MK, et al. Successful implementation of spacer treatment guideline for acute asthma. Arch Dis Child 2001; 84: 142-6
67. Toogood JH, White FA, Baskerville JC, et al. Comparison of the antiasthmatic oropharyngeal and systemic glucocorticoid effects of budesonide administered through a pressurized aerosol plus spacer or the Turbuhaler Dry Powder Inhaler. J Allergy Clin Immunol 1997; 99: 186-93
68. Denyer J, Pavia D, Zierenberg B. New liquid drug aerosol devices for inhalation therapy. Eur Respir Rev 2000; 10: 187-91
69. Bisgaard H. Automatic actuation of a dry powder inhaler into a non-electrostatic spacer. Am J Respir Crit Care Med 1998; 157: 518-21
70. O'Callaghan C, Barry PW. How to choose delivery devices for asthma. Arch Dis Child 2000; 82: 185-7
71. O'Callaghan C, Barry P. Asthma drug delivery devices for children [editorial]. BMJ 2000; 320: 664
72. Everard ML. Guidelines for devices and choices. J Aerosol Med 2001; 14: S59-64
73. Buck H. The ideal inhaler for asthma therapy. Medl Device Technol 2001; 1: 24-7
74. Kamps AW, van Ewijk B, Roorda RJ, et al. Poor inhalation technique even after inhalation instructions in children with asthma. Pediatr Pulmonol 2000; 29: 39-42