Extra-fine particles improve lung delivery of inhaled steroids in infants: A study in an upper airway model

Chest

Volumn 123, Issue 6, 2003, Pages 2083-2088

  Janssens, Hettie M ^a   De Jongste, Johan C ^a   Hop, Wim C J ^a   Tiddens, Harm A W M ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Aerosol deposition; Airway model; Beclomethasone; Hydrofluoroalkane; Infants; Metered dose inhalers

Indexed keywords

BECLOMETASONE DIPROPIONATE; CHLOROFLUOROCARBON; NORFLURANE;

AEROSOL; ARTICLE; BREATHING PATTERN; DRUG DELIVERY SYSTEM; INFANT DISEASE; METERED DOSE INHALER; MODEL; PARTICLE SIZE; PRIORITY JOURNAL; SIMULATOR; TIDAL VOLUME; UPPER RESPIRATORY TRACT; WHEEZING;

EID: 0038047521     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.123.6.2083     Document Type: Article

References (28)

1. Mellon M. Efficacy of budesonide inhalation suspension in infants and young children with persistent asthma: Budesonide Inhalation Suspension Study Group. J Allergy Clin Immunol 1999; 104:191-199
2. Conner WT, Dolovich MB, Frame RA, et al. Reliable salbutamol administration in 6- to 36-month-old children by means of a metered dose inhaler and Aerochamber with mask. Pediatr Pulmonol 1989; 6:263-267
3. Fok TF, Monkman S, Dolovich M, et al. Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1996; 21:301-309
4. Tal A, Golan H, Grauer N, et al. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction. J Pediatr 1996; 128:479-484
5. Janssens HM, Heijnen EM, de Jong VM, et al. Aerosol delivery from spacers in wheezy infants: a daily life study. Eur Respir J 2000; 16:850-856
6. Cummings RH. Pressurized metered dose inhalers: chlorofluorocarbon to hydrofluoroalkane transition-valve performance. J Allergy Clin Immunol 1999; 104:S230-S236
7. Leach CL, Davidson PJ, Boudreau RJ. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur Respir J 1998; 12:1346-1353
8. Chua HL, Collis GG, Newbury AM, et al. The influence of age on aerosol deposition in children with cystic fibrosis. Eur Respir J 1994; 7:2185-2191
9. Becquemin MH, Swift DL, Bouchikhi A, et al. Particle deposition and resistance in the noses of adults and children. Eur Respir J 1991; 4:694-702
10. Iles R, Lister P, Edmunds AT. Crying significantly reduces absorption of aerosolised drug in infants. Arch Dis Child 1999; 81:163-165
11. Janssens HM, Krijgsman AM, Verbraak AFM, et al. Lung deposition of inhaled steroids delivered by pMDI-spacer combinations: studies in an infant upper airway model [abstract]. Am J Respir Crit Care Med 2000; 161:A32
12. Phalen RF, Oldham MJ, Mautz WJ. Aerosol deposition in the nose as a function of body size. Health Phys 1989; 57:299-305
13. Swift DS. Age-related scaling for aerosol and vapor deposition in the upper airways of humans. Health Phys 1989; 57:293-297
14. Dolovich MA. Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung. Respir Care 2000; 45:597-608
15. Everard ML. Studies using radiolabelled aerosols in children. Thorax 1994; 49:1259-1266
16. Janssens HM, Jongste de JC, Fokkens WJ, et al. The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infants. J Aerosol Med 2001; 14:433-441
17. Wildhaber JH, Dore ND, Wilson JM, et al. Inhalation therapy in asthma: nebulizer or pressurized metered-dose inhaler with holding chamber? In vivo comparison of lung deposition in children. J Pediatr 1999; 135:28-33
18. Wildhaber JH, Janssens HM, Pierart F, et al. High-percentage lung delivery in children from detergent-treated spacers. Pediatr Pulmonol 2000; 29:389-393
19. Barry PW, O'Callaghan C. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler. Br J Clin Pharmacol 1995; 40:76-78
20. Wildhaber JH, Devadason SG, Hayden MJ, et al. Electrostatic charge on a plastic spacer device influences the delivery of salbutamol. Eur Respir J 1996; 9:1943-1946
21. Pierart F, Wildhaber JH, Vrancken I, et al. Washing plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery. Eur Respir J 1999; 13:673-678
22. Berg E, Asking L, Svensson JO. Is it possible to measure the particle size distribution from a pMDI/spacer during simulated breathing [abstract]? Eur Respir J 1997; 10:81s
23. Finlay WH, Zuberbuhler P. In vitro comparison of beclomethasone and salbutamol metered-dose inhaler aerosols inhaled during pediatric tidal breathing from four valved holding chambers. Chest 1998; 114:1676-1680
24. Stick S. Measurements during tidal breathing. In: Stocks J, Sly P, Tepper R, et al, eds. Infant respiratory function testing. New York, NY: Wiley-Liss, 1996; 134
25. Devadason SG, Huang T, Turner SW, et al. Distribution of 99mTc-labelled HFA-BDP inhaled via Autohaler in children [abstract]. Eur Respir J 2000; 16:540S
26. Newman SP, Pavia D, Garland N, et al. Effects of various inhalation modes on the deposition of radioactive pressurized aerosols. Eur J Respir Dis Suppl 1982; 119:57-65
27. Martonen TB, Mathematical model for the selective deposition of inhaled pharmaceuticals. J Pharm Sci 1993; 82:1191-1199
28. Busse WW, Brazinsky S, Jacobson K, et al. Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with a new propellant. J Allergy Clin Immunol 1999; 104:1215-1222