Effectiveness of polyene antibiotics in treatment of transmissible spongiform encephalopathy in transgenic mice expressing Syrian hamster PrP only in neurons

Journal of Virology

Volumn 73, Issue 4, 1999, Pages 3511-3513

  Demaimay, Remi ^a   Race, Richard ^a   Chesebro, Bruce ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; MS 8209; POLYENE ANTIBIOTIC AGENT; PRION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; GENE INACTIVATION; INCUBATION TIME; INTRACEREBRAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; SCRAPIE AGENT; SYRIAN HAMSTER; TRANSGENIC MOUSE; TREATMENT OUTCOME; VIRUS REPLICATION; VIRUS STRAIN;

EID: 0033050207     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.4.3511-3513.1999     Document Type: Article

References (23)

1. Adjou, K. T., R. Demaimay, C. Lasmezas, J.-P. Deslys, M. Seman, and D. Dormont 1995. MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie. Antimicrob. Agents Chemother. 39:2810-2812.
2. Bessen, R. A., and R. F. Marsh. 1992. Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters. J. Gen. Virol. 73:329-334.
3. Bessen, R. A., and R. F. Marsh. 1994. Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy. J. Virol. 68:7859-7868.
4. Bolton, D. C., M. P. McKinley, and S. B. Prusiner. 1982. Identification of a protein that purifies with the scrapie prion. Science 218:1309-1311.
5. Caughey, B., and B. Chesebro. 1997. Prion protein and the transmissible spongiform encephalopathies. Trends Cell Biol. 7:56-62.
6. Demaimay, R., K. Adjoo, C. Lasmezas, F. Lazarini, K. Cherifi, M. Seman, J. P. Deslys, and D. Dormont. 1994. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J. Gen. Virol. 75:2499-2503.
7. Demaimay, R., K. T. Adjou, V. Beringue, S. Demart, C. I. Lasraézas. J.-P. Deslys, M. Seman, and D. Dormont. 1997. Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals. J. Virol. 71:9685-9689.
8. Ehlers, B., and H. Dlringer. 1984. Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen. J. Gen. Virol. 65:1325-1330.
9. Farquhar, C. F., and A. G. Dickinson. 1986. Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection. J. Gen. Virol. 67:463-473.
10. Kascsak, R. J., R. Rubenstein, P. A. Merz, M. Tonna-DeMasi, R. Fersko, R. I. Carp, H. M. Wisniewski, and H. Diringer. 1987. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J. Virol. 61:3688-3693.
11. Kimberlin, R. H., and C. A. Walker. 1986. Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions. Antimicrob. Agents Chemother. 30:409-413.
12. Kocisko, D. A., P. T. Lansbury, Jr., and B. Caughey. 1996. Partial unfolding and refolding of scrapie-associated prion protein: evidence for a critical 16-kDa C-terminal domain. Biochemistry 35:13434-13442.
13. Ladogana, A., P. Casaccia, L. Ingrosso, M. Cibati, M. 0Salvatore, Y. G. Xi, C. Masullo, and M. Pocchiari. 1992. Sulphate polyanions prolong the incubation period of scrapie-infected hamsters. J. Gen. Virol. 73:661-665.
14. Manson, J. C., A. R. Clarke, P. A. McBride, I. McConnell, and J. Hope. 1994. PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology. Neurodegeneration 3:331-340.
15. McKenzie, D., J. Kaczkowski, R. Marsh, and J. Aiken. 1994. Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection. J. Virol. 68:7534-7536.
16. Pocchiari, M., S. Schmittinger, and C. Masullo. 1987. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. J. Gen. Virol. 68:219-223.
17. Prusiner, S. B. 1982. Novel proteinaceous infectious particles cause scrapie. Science 216:136-144.
18. Prusiner, S. B. 1991. Molecular biology of prion diseases. Science 252:1515-1522.
19. Race, R. E., S. A. Priola, R. A. Bessen, D. R. Ernst, J. Dockter, G. F. Rail, L. Mucke, B. Chesebro, and M. B. A. Oldstone. 1995. Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent. Neuron 15:1183-1191.
20. Raeber, A. J., R. E. Race, S. Brandner, S. A. Priola, A. Sailer, R. A. Bessen, L. Mucke, J. Manson, A. Aguzzi, M. B. A. Oldstone, C. Welssman, and B. Chesebro. 1997. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J. 16: 6057-6065.
21. Saint-Julien, L., V. Joly, M. Seman, C. Carbon, and P. Yeni. 1992. Activity of MS-8209, a nonester amphotericin B derivative, in treatment of experimental systemic mycoses. Antimicrob. Agents Chemother. 36:2722-2728.
22. Scott, M., D. Foster, C. Mirenda, D. Serban, F. Coufal, M. Walchli, M. Torchia, D. Groth, G. Carlson, S. J. DeArmond, D. Westaway, and S. B. Prusiner. 1989. Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell 59:847-857.
23. Xi, Y. G., L. Ingrosso, A. Ladogana, C. Masullo, and M. Pocchiari. 1992. Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation. Nature 356:598-601.