Effect of dehydroepiandrosterone supplementation on fatty acid and hormone levels in patients with X-linked adrenoleucodystrophy

Clinical Endocrinology

Volumn 59, Issue 4, 2003, Pages 459-466

  Assies, J ^a   Haverkort, E B ^a   Lieverse, R ^b   Vreken, P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b GGZ Buitenamstel ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; CORTISONE ACETATE; FATTY ACID; FLUDROCORTISONE ACETATE; HORMONE; HYDROCORTISONE; MONOUNSATURATED FATTY ACID; PLACEBO; POLYUNSATURATED FATTY ACID; PRASTERONE; PRASTERONE SULFATE; SOMATOMEDIN; TESTOSTERONE; TESTOSTERONE UNDECANOATE; VERY LONG CHAIN FATTY ACID;

ADRENAL CORTEX INSUFFICIENCY; ADRENOLEUKODYSTROPHY; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ERYTHROCYTE; HORMONE BLOOD LEVEL; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ADRENOLEUKODYSTROPHY; ADULT; ANDROSTENEDIONE; CHILD; DEHYDROEPIANDROSTERONE; DOUBLE-BLIND METHOD; ERYTHROCYTES; FATTY ACIDS; FATTY ACIDS, UNSATURATED; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED;

EID: 0141616465     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2003.01868.x     Document Type: Article

References (42)

1. Arlt, W., Callies, F., van Vlijmen, J.C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schult, H.M. & Allolio, B. (1999) Dehydroepiandrosterone replacement in women with adrenal insufficiency. New England Journal of Medicine, 341, 1013-1020.
2. Arlt, W., Callies, F., Koehler, I., van Vlijmen, J.C., Fassnacht, M., Strasburger, C.J., Seibel, M.J., Huebler, D., Ernst, M., Oettel, M., Reincke, M., Schulte, H.M. & Allolio, B. (2001) Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion. Journal of Clinical Endocrinology and Metabolism, 86, 4686-4692.
3. Assies, J., Gooren, L.J.G., van Geel, B.M. & Barth, P.G. (1997) Signs of testicular insufficiency in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy: a retrospective study. International Journal of Andrology, 20, 315-321.
4. Assies, J., van Geel, B.M. & Barth, P.G. (1998) Low dehydroepiandrosterone sulphate (DHEAS) levels in X-linked adrenoleukodystrophy. Clinical Endocrinology, 49, 691-693.
5. Baulieu, E.E. (1996) Dehydroepiandrosterone (DHEA): a fountain of youth? Journal of Clinical Endocrinology and Metabolism, 81, 3147-3151.
6. Baulieu, E.E. (1997) Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Progress in Hormone Research, 52, 1-32.
7. Bezman, L., Moser, A.B., Raymond, G.V., Rinaldo, P., Watkins, P.A., Smith, K.D., Kass, N.E. & Moser, H.W. (2001) Adrenoleukodystrophy: incidence, new mutation rate, and results of extended family screening. Annals of Neurology, 49, 5162-5171.
8. Dacremont, G., Cocquyt, G. & Vincent, G. (1995) Measurements of very long-chain fatty acids, phytanic and pristanic acid in plasma and cultured fibroblasts by gas chromatography. Journal of Inherited and Metabolic Diseases, 18, 76-83.
9. Depreter, M., Vandesompele, J., Espeel, M., Speleman, F. & Roels, F. (2002) Modulation of the peroxisomal gene expression pattern by dehydroepiandrosterone and vitamin D: therapeutic implications.. Journal of Endocrinology, 175, 779-792.
10. Di Biase, A., Merendino, N., Avellino, C., Cappa, M. & Salvati, S. (2001) The cytokine production by peripheral blood mononuclear cells in X-linked adrenoleukodystrophy. Journal of Neurological Sciences, 182, 161-165.
11. Dubois-Dalcq, M., Feigenbaum, V. & Aubourg, P. (1999) The neurobiology of X-linked adrenoleukodystrophy, a demyelinating peroxisomal disorder. Trends in Neuroscience, 22, 4-12.
12. Flynn, M.A., Weaver-Osterholz, D., Sharpe-Timms, K.L., Allen, S. & Krause, G. (1999) Dehydoepiandrosterone replacement in ageing humans. Journal of Clinical Endocrinology and Metabolism, 84, 1527-1533.
13. Frenkel, R.A., Slaughter, C.A., Orth, K., Moomaw, C.R., Hicks, S.H., Snyde, J.M., Bennett, M., Prough, R.A., Putnam, R.S. & Milevich, L.J. (1990) Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding. Steroid Biochemistry, 35, 333-345.
14. Friess, E., Schiffelholz, T., Steckler, T. & Steiger, A. (2000) Dehydroepiandrosterone - a neurosteroid. European Journal of Clinical Investigation, 30 (Suppl. 3), 46-50.
15. van Geel, B.M., Assies, J., Haverkort, E.B., Koelman, J.H.T., Verbeeten, B., Jr, Wanders, R.J.A. & Barth, P.G. on behalf of the Dutch X-ALD/AMN Study Group. (1999) Progression of abnormalities in adrenomyelone-uropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with 'Lorenzo's oil'. Journal of Neurology, Neurosurgery and Psychiatry, 67, 290-299.
16. van Geel, B.M., Assies, J., Wanders, R.J.A. & Barth, P.G. (1997) X-linked adrenoleukodystrophy: clinical presentation, diagnosis, and therapy. Journal of Neurology, Neurosurgery, and Psychiatry, 63, 4-14.
17. Guazzo, E.P., Kirckpatrick, P.J., Goodyer, I.M., Shiers, H.M. & Herbert, J.P. (1996) Cortisol, dehydroepiandrosterone (DHEA) and DHEA-sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age. Journal of Clinical Endocrinology and Metabolism, 81, 3951-3960.
18. Hunt, P.J., Gurnell, E.M., Huppert, F.A., Richards, C., Toby Prevost, A., Wass, J.A.H., Herbert, J. & Chatterjee, K.K. (2000) Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomised, double blind trial. Journal of Clinical Endocrinology and Metabolism, 85, 4650-4656.
19. Judd, A.M., Call, G.B., Barney, M., McIlmoil, C.J., Balls, A.G., Adams, A. & Oliveira, G.K. (2000) Possible function of IL-6 and TNF as intraadrenal factors in the regulation of adrenal steroid secretion. Annals of the New York Academy of Sciences, 917, 628-637.
20. Katan, M.D., Deslypere, J.P., van Birgelen, A.P., Penders, M. & Zegwaard, M. (1997) Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocytes membranes, and adipose tissue: an 18 month controlled study. Journal of Lipid Research, 38, 2012-2022.
21. Kemp, S., Pujol, A., Waterham, H.R., van Geel, B.M., Boehm, C.D., Raymond, G.V., Cutting, G.R., Wanders, R.J.A. & Moser, H.W. (2001) ABCDI mutations and the X-linked adrenoleukodystrophy mutation database: role in diagnosis and clinical correlations. Human Mutation, 18, 499-515.
22. Kipper-Galperin, M., Galilly, R., Danenberg, H.D. & Brenner, T. (1999) Dehydroepiandrosterone selectively inhibits production of tumor necrosis factor α and interleukin-6 in astrocytes. International Journal of Developmental Neuroscience, 17, 765-775.
23. Korenke, G.C., Roth, C., Krasemann, E., Hufner, M., Hunneman, D.H. & Hanefeld, F. (1997) Variability of endocrinological dysfunction in 55 patients with X-linked adrenoleukodystrophy: clinical, laboratory and genetic findings. European Journal of Endocrinology, 137, 40-47.
24. Kroboth, P.D., Salek, F.S., Pittenger, A.L., Fabian, T.J. & Frye, R.F. (1999) DHEA and DHEA-S: a review. Journal of Clinical Pharmacology, 39, 327-348.
25. Lannuzel, A., Aubourg, P. & Tardieu, M. (1998) Excessive production of tumour necrosis factor α by peripheral blood mononuclear cells in X-linked adrenoleukodystrophy. European Journal of Paediatric Neurology, 1, 27-32.
26. Moser, H.W. (1997) Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy. Brain, 120, 1485-1508.
27. Mosser, J., Douar, A.M., Sarde, C.O., Kioschis, P., Feil, R., Moser, H., Poustka, A.M., Mandel, J.L. & Aubourg, P. (1993) Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature, 361, 726-730.
28. Nestler, J.E. (1996) Advances in understanding the regulation and biologic actions of dehydroepiandrosterone. Current Opinion in Endocrinology and Diabetes, 3, 202-211.
29. Parker, C.R. (1999) Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids, 64, 640-647.
30. Parker, C.R., Azziz, R., Potter, H.D. & Boots, L.R. (1996) Adrenal androgen production in response to adrenocorticotropin infusions in men. Endocrine Research, 22, 717-722.
31. Petroni, A., Papini, N., Blasevich, M., Cavaretta, I., Galli, C. & Melcangi, R.C. Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts. Neuroscience Letters, 289, 139-142.
32. Powers, J.M. (1985) Adrenoleukodystrophy (adreno-testiculo-leukomyelo-neuropathic-complex). Clinical Neuropathology, 4, 181-199.
33. Powers, J.M., Liu, Y., Moser, A.B. & Moser, H.W. The inflammatory myelinopathy of adreno-leukodystrophy: cells, effector molecules, and pathogenetic implications. Journal of Neuropathology and Experimental Neurology, 51/6, 630-643.
34. Rook, A.W., Hernandez-Pando, R. & Lightman, S.L. (1994) Hormones, peripherally activated prohormones and the regulation of the Th1/Th2 balance. Immunology Today, 15, 301-303.
35. Sargent, J.R., Coupland, K. & Wilson, R. (1994) Nervonic acid and demyelinating diseases. Medical Hypotheses, 4, 237-242.
36. Sulcova, J., Hill, M., Hampl, R. & Starka, L. (1997) Age and sex related differences in serum levels of conjugated dehydroepiandrosterone and its sulphate in normal subjects. Journal of Endocrinology, 154, 57-62.
37. Svec, F. & Porter, J.R. (1998) The actions of exogenous dehydroepiandrosterone in experimental animals and humans. Proceedings of the Society of Experimental Biology and Medicine, 218, 174-191.
38. Tilvis, R.S. & Miettinen, T.A. (1985) Fatty acid compositions of serum lipids, erythrocytes and platelets in insulin-dependent diabetic women. Journal of Clinical Endocrinology and metabolism, 61, 741-745.
39. Vessby, B., Gustafsson, I.-B., Tengblad, S., Boberg, M., & Andersson, A. (2002) Desaturation and elongation of fatty acids and insulin action. Annals of the New York Academy of Sciences, 967, 183-195.
40. Waxman, D.J. (1996) Role of metabolism in the activation of the dehydroepiandrosterone as a peroxisome proliferator. Journal of Endocrinology, 150, S129-S147.
41. Whitcomb, R.W., Linehan, W.M. & Knazek, R.A. (1988) Effect of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vivo. Journal of Clinical Investigation, 81, 185-188.
42. Wolkowitz, O.W., Kroboth, P.D., Reus, V.I. & Fabian, T.J. (2000) Dehydroepiandrosterone in ageing and mental health. In Hormones, Gender and Ageing Brain (ed. M.F. Morrison), pp. 145-167. Cambridge University Press, Cambridge.