The proof of the pudding is in the eating: Editorial focus on "hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4-receptor knockout mice"

Physiological Genomics

Volumn 13, Issue , 2003, Pages 11-14

  MacIntyre, D Euan ^a   Glueck, Susan B ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MELANOCORTIN 4 RECEPTOR; CORTICOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; BODY COMPOSITION; BODY MASS; CALORIC INTAKE; EDITORIAL; ENERGY EXPENDITURE; FEEDING; GENE EXPRESSION; GENOTYPE; HOMOZYGOSITY; HYPERPHAGIA; KNOCKOUT MOUSE; MALE; METABOLIC DISORDER; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; OBESITY; PRIORITY JOURNAL; THERMOGENESIS; ANIMAL; BASAL METABOLIC RATE; BLOOD; GENETICS; MOUSE; MOUSE MUTANT; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALIA;

ANIMALS; BASAL METABOLISM; HYPERPHAGIA; MICE; MICE, KNOCKOUT; MICE, OBESE; OBESITY; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN;

EID: 0141591477     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00018.2003     Document Type: Editorial

References (16)

1. Barsh G and Schwartz MW. Genetic approaches to studying energy balance perception and integration. Nat Genet 3: 589-600, 2002.
2. Butler AA and Cone RD. Knockout models resulting in the development of obesity. Trends Genet 17: S51-S54, 2001.
3. Butler AA and Cone RD. The melanocortin receptors: lessons from knockout models. Neuropeptides 36: 77-84, 2002.
4. Chen AS, Metzger JM, Trumbauer ME, Guan X, Yu H, Frazier EG, Marsh DJ, Forrest MJ, Gopal-Truter S, Fisher J, Camacho R, Strack AM, Mellin TN, MacIntyre DE, Chen HY, and Van der Ploeg LHT. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res 9: 145-154, 2000.
5. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, and Low MJ. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411: 480-484, 2001.
6. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkmeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, and Lee F. Targeted disruption of the melanocortin 4 receptor results in obesity in mice. Cell 88: 131-141, 1997.
7. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, and Elmquist JK. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 457: 213-235, 2003.
8. MacNeil D, Howard AH, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ, Chen HY, Shen C, Chen AS, Rosenblum CI, MacNeil T, Tota M, MacIntyre DE, and Van der Ploeg LHT. The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur J Pharmacol 450: 93-109, 2002.
9. Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P, and Palmiter RD. Response of melanocortin-4-deficient mice to anorectic and orexigenic peptides. Nat Genet 21: 119-122, 1999.
10. Saper CB, Chou TC, and Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron 36: 199-211, 2002.
11. Schwartz MW, Woods SC, Porte D, Seeley RJ, and Baskin DG. Central nervous system control of food intake. Nature 404: 661-671, 2000.
12. Schwartz MW, Woods SC, Seeley RJ, Barsh GS, Baskin DG, and Leibel RL. Is the energy homeostasis system inherently biased towards weight gain. Diabetes 52: 232-238, 2003.
13. Ste Marie L, Miura GI, Marsh DJ, Yagaloff K, and Palmiter RD. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci USA 97: 12339-12344, 2000.
14. Trayhurn P and Fuller L. The development of obesity in genetically dibaetic-obese (db/db) mice pair-fed with lean siblings. The importance of thermoregulatory thermogenesis. Diabetologia 19: 148-153, 1980.
15. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grandm B, and Frogel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106: 253-262, 2000.
16. Weide K, Christ N, Moar KM, Arens J, Hinney A, Mercer JG, Eiden S, and Schmidt I. Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4-receptor knockout mice. Physiol Genomics 13: 47-56, 2003. First published January 14, 2003; 10.1152/physiolgenomics.00129. 2002.