Reduced intrafollicular androstenedione and estradiol levels in early-treated prenatally androgenized female rhesus monkeys receiving follicle-stimulating hormone therapy for in vitro fertilization

Biology of Reproduction

Volumn 69, Issue 4, 2003, Pages 1213-1219

  Dumesic, Daniel A ^a,b,d   Dee Schramm, R ^b   Bird, Ian M ^c   Peterson, Eric ^b   Paprocki, Ann Marie ^b   Zhou, Rao ^b   Abbott, David H ^b,c  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d MAYO CLINIC ROCHESTER   (United States)

Author keywords

Estradiol; Follicular development; Granulosa cells; In vitro fertilization; Insulin

Indexed keywords

ANDROSTANOLONE; ANDROSTENEDIONE; CHORIONIC GONADOTROPIN; ESTRADIOL; FOLLITROPIN; HYDROXYPROGESTERONE; INSULIN; LUTEINIZING HORMONE; PROGESTERONE; RECOMBINANT FOLLITROPIN; SEX HORMONE; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ANDROGEN THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; FERTILIZATION IN VITRO; FOLLICLE FLUID; GESTATIONAL AGE; GRANULOSA CELL; NONHUMAN; OOCYTE; OOCYTE CLEAVAGE; OOCYTE DEVELOPMENT; OVARY FOLLICLE DEVELOPMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; RHESUS MONKEY; STEROID BLOOD LEVEL; STEROIDOGENESIS; ZYGOTE;

ANDROGENS; ANDROSTENEDIONE; ANIMALS; BLOOD GLUCOSE; ESTRADIOL; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; HORMONES; INSULIN; MACACA MULATTA; MALE; OOCYTES; OVARIAN FOLLICLE; RECOMBINANT PROTEINS;

ANIMALIA; FALLOPIA; MACACA MULATTA;

EID: 0141572335     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.102.015164     Document Type: Article

References (38)

1. Schramm RD, Bavister BD. A macaque model for studying mechanisms controlling oocyte development and maturation in human and nonhuman primates. Hum Reprod 1999; 14:2544-2555.
2. Chaffin CL, Hess DL, Stouffer RL. Dynamics of periovulatory steroidogenesis in the rhesus monkey follicle after ovarian stimulation. Hum Reprod 1999; 14:642-649.
3. Chaffin CL, Dissen GA, Stouffer RL. Hormonal regulation of steroidogenic enzyme expression in granulosa cells during the periovulatory interval in monkeys. Mol Hum Reprod 2000; 6:11-18.
4. Dumesic DA, Abbott DH, Eisner JR, Goy RW. Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood. Fertil Steril 1997; 67:155-163.
5. Abbott DA, Dumesic DA, Eisner JR, Colman RJ, Kemnitz JW. Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys. Trends Endocrinol Metab 1998; 9:62-67.
6. Abbott DH, Dumesic DA, Eisner JR, Kemnitz JW, Goy RW. The prenatally androgenized female rhesus monkey as a model for PCOS. In: Azziz R, Nestler JE, Dewailly D (eds.), Androgen Excess Disorders in Women. Philadelphia: Lippincott-Raven; 1997:369-382.
7. Eisner JR, Dumesic DA, Kemnitz JW, Abbott DH. Timing of prenatal androgen excess determines differential impairment of insulin secretion and action in adult female rhesus monkeys. J Clin Endocrinol Metab 2000; 85:1206-1210.
8. Eisner JR, Barnett MA, Dumesic DA, Abbott DH. Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess. Fertil Steril 2002; 77:167-172.
9. Dumesic DA, Schramm RD, Peterson E, Paprocki AM, Zhou R, Abbott DH. Impaired developmental competence of oocytes in adult prenatally androgenized female rhesus monkeys undergoing gonadotropin stimulation for in vitro fertilization. J Clin Endocrinol Metab 2002; 87:1111-1119.
10. Goy RW, Robinson JA. Prenatal exposure of rhesus monkeys to patent androgens: morphological, behavioral, and physiological consequences. Banbury Report 1982; 11:355-378.
11. Goy RW, Kemnitz JW. Early, persistent and delayed effects of virilizing substances delivered transplacentally to female rhesus monkeys. In: Zbinden G, Cuomo V, Racagni G, Weiss B (eds.), Applications of Behavioral Pharmacology in Toxicology. New York: Raven Press; 1983:303-314.
12. Dailey RA, Neill JD. Seasonal variation in reproductive hormones of rhesus monkeys: anovulatory and short luteal phase menstrual cycles. Biol Reprod 1981; 25:560-567.
13. Nusser KD, Mitalipov S, Widmann A, Gerami-Naini B, Yeoman RR, Wolf DP. Developmental competence of oocytes after ICSI in the thesus monkey. Hum Reprod 2001; 16:130-137.
14. Goy RW, Uno H, Sholl SA. Psychological and anatomical consequences of prenatal exposure to androgens in female rhesus. In: Mori T, Nagasawa H (eds.), Toxicity of Hormones in Perinatal Life. Boca Raton: CRC Press Inc.; 1988:127-142.
15. Kemnitz JW, Goy RW, Flitsch TJ, Lohmiller JJ, Robinson JA. Obesity in male and female rhesus monkeys: fat distribution, glucoregulation, and serum androgen levels. J Clin Endocrinol Metab 1989; 69:287-293.
16. Schramm RD, Bavister BD. Development of in-vitro-fertilized primate embryos into blastocysts in a chemically defined, protein-free culture medium. Hum Reprod 1996; 11:1690-1697.
17. Schramm RD, Bavister BD. Onset of nucleolar and extranucleolar transcription and expression of fibrillarin in macaque embryos developing in vitro. Biol Reprod 1999; 60:721-728.
18. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-254.
19. Boatman D. In vitro growth of non-human primate pre- and periimplantation embryos. In: Bavister B (ed.), The Mammalian Preimplantation Embryo. New York: Plenum Press; 1987:273-308.
20. Bavister BD, Boatman, DE, Leibfried LM, Loose M, Vernon MW. Fertilization and cleavage of rhesus monkey oocytes in vitro. Biol Reprod 1983; 28:983-999.
21. Boatman D, Bavister B. Stimulation of rhesus monkey sperm capacitation by cyclic nucleotide mediators. J Reprod Fertil 1984; 71:357-366.
22. Gardner DK, Lane M. Culture and selection of viable blastocysts: a feasible proposition for human IVF? Hum Reprod Update 1997; 3:367-382.
23. Warikoo PK, Bavister BD. Hypoxanthine and cyclic adenosine 5′-monophosphate maintain meiotic arrest of rhesus monkey oocytes in vitro. Fertil Steril 1989; 51:886-889.
24. Edwards RG. The pre-implantation and implanting human embryo. In: Jauniaux E, Barnea E, Edwards R (eds.), Embryonic Medicine and Therapy. Oxford, U.K.: Oxford University Press; 1997:3-31.
25. Sokal RR, Rohlf FJ. Biometry, the Principles and Practice of Statistics in Biological Research, 3rd ed. New York: WH Freeman and Co.; 1995:413-422.
26. Agarwal SK, Judd HL, Magoffin DA. A mechanism for the suppression of estrogen production in polycystic ovary syndrome. J Clin Endocrinol Metab 1996; 81:3686-3691.
27. Jakimiuk AJ, Weitsman SR, Magoffin DA. 5α-Reductase activity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1999; 84:2414-2418.
28. McNatty KP, Smith DM, Makris A, Osathanondh R, Ryan KJ. The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro. J Clin Endocrinol Metab 1979; 49:851-860.
29. Jakimiuk AJ, Weitsman SR, Brzechffa PR, Magoffin DA. Aromatase mRNA expression in individual follicles from polycystic ovaries. Mol Hum Reprod 1998; 4:1-8.
30. Slater CC, Chang L, Stanczyk FZ, Paulson RJ. Altered balance between the 5α-reductase and aromatase pathways of androgen metabolism during controlled ovarian hyperstimulation with human menopausal gonadotropins. J Assist Reprod Genet 2001; 18:527-533.
31. Hillier SG, Whitelaw PF, Smyth CD. Follicular oestrogen synthesis: the 'two-cell, two-gonadotropin' model revisited. Mol Cell Endocrinol 1994; 100:51-54.
32. Smyth CD, Miro F, Whitelaw PE Howles CM, Hillier SG. Ovarian thecal/interstitial androgen synthesis is enhanced by a follicle-stimulating hormone-stimulated paracrine mechanism. Endocrinology 1993; 133:1532-1538.
33. Barnes RB, Rosenfield RL, Namnoun A, Layman LC. Effect of follicle-stimulating hormone on ovarian androgen production in a woman with isolated follicle-stimulating hormone deficiency. N Engl J Med 2000; 343:1197-1198.
34. Barnes RB, Namnoun A, Rosenfield RL, Layman LC. The role of LH and FSH in ovarian androgen secretion and ovarian follicular development: clinical studies in a patient with isolated FSH deficiency and multicystic ovaries. Hum Reprod 2002; 17:88-91.
35. Steiner RA, Clifton DK, Spies HG, Resko JA. Sexual differentiation and feedback control of luteinizing hormone secretion in the rhesus monkey. Biol Reprod 1976; 15:206-212.
36. Pastor CL, Griffin-Kork ML, Aloi JA, Evans WS, Marshall JC. Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J Clin Endocrinol Metab 1998; 83:582-590.
37. Doeden B, Rizza R. Use of variable insulin infusion to assess insulin action in obesity: defects in both the kinetics and amplitude of response. J Clin Endocrinol Metab 1987; 64:902-908.
38. Eppig JJ, O'Brien MJ, Pendola FL, Watanabe S. Factors affecting the developmental competence of mouse oocytes grown in vitro: follicle-stimulating hormone and insulin. Biol Reprod 1998; 59:1445-1453.