Altered balance between the 5α-reductase and aromatase pathways of androgen metabolism during controlled ovarian hyperstimulation with human menopausal gonadotropins

Journal of Assisted Reproduction and Genetics

Volumn 18, Issue 10, 2001, Pages 527-533

  Slater, Cristin C ^a   Chang, Lilly ^a   Stanczyk, Frank Z ^a   Paulson, Richard J ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

5 reductase; Androgen metabolism; Aromatase; Controlled ovarian hyperstimulation

Indexed keywords

ANDROGEN; ANDROSTANEDIOL GLUCURONIDE; ANDROSTENEDIOL DERIVATIVE; ANDROSTENEDIONE; AROMATASE; CHORIONIC GONADOTROPIN; ESTRADIOL; ESTRONE; GONADOTROPIN; SEX HORMONE BINDING GLOBULIN; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ANDROGEN BLOOD LEVEL; ANDROGEN METABOLISM; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HORMONE DETERMINATION; HUMAN; MENOPAUSE; OVARY HYPERSTIMULATION; PRIORITY JOURNAL;

ADULT; ANDROSTANE-3,17-DIOL; ANDROSTENEDIONE; AROMATASE; ESTRADIOL; ESTRONE; FEMALE; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; HUMANS; OVULATION INDUCTION; PREGNANCY; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE;

FALLOPIA;

EID: 0034768831     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011914218410     Document Type: Article

References (26)

1. Exogenous gonadotropin stimulation is associated with increases in serum androgen levels in in-vitro fertilization-embryo transfer cycles
2. The climacteric ovary as a functional gonadotropin-driven androgen-producing gland
3. Incomplete androgen and progesterone suppression following midluteal GnRHa prior to controlled ovarian hyperstimulation for IVF-ET
4. Premature plasma progesterone and androgen elevation are not prevented by adrenal suppression in in vitro fertilization
5. Differential regulation of cholesterol side-chain cleavage (P450scc) and aromatase (P450arom) enzyme mRNA expression by gonadotrophins and cyclic AMP in human granulosa cells
6. Ovulation induction with human menopausal gonadotropin compared to human urinary follicle-stimulating hormone results in a significant shift in follicular fluid androgen levels without discernible differences in granulosa-luteal cell function
7. Regulation by follicle-stimulating hormone of the synthesis of aromatase cytochrome P-450 in human granulosa cells
8. Hormonal regulation of the growth and steroidogenic function of human granulosa cells
9. Measurements of 3α, 17β-androstanediol glucuronide in serum and urine and the correlation with skin 5α-reductase activity
10. Male pseudohermaphroditism due to testicular 17β-hydroxysteroid dehydrogenase deficiency
11. Serum testosterone concentrations in women throughout the menstrual cycle and following hCG administration
12. A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women
13. Serum gonadotropin, testosterone, estradiol and estrone levels prior to and following bilateral vasectomy
14. Steroid hormones
15. Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: Evidence for a reduced 17, 20-desmolase enzymatic activity
16. Normal ovarian function in a mild form of late-onset 3β-hydroxysteroid dehydrogenase deficiency
17. Absence of molecular defect in the type II 3β-hydroxysteroid dehydrogenase (3β-HSD) gene in premature pubarche children and hirsute female patients with moderately decreased adrenal 3β-HSD activity
18. Hormone biosynthesis, metabolism, and mechanism of action
19. Reproductive hormones and their mechanisms of action
20. Steroidal and non-steroidal factors in plasma sex hormone binding globulin regulation
21. Effects of sex steroids on skin 5α-reductase activity in vitro
22. Inhibition of androgen metabolism in stroma and epithelium of the human benign prostatic hyperplasia by progesterone, estrone, and estradiol
23. The effect of spironolactone on genital skin 5α-reductase activity
24. Prolactin modulates peripheral androgen metabolism
25. Treatment of hirsutism by oral cyproterone acetate and percutaneous estradiol
26. The effect of five synthetic progestational compounds on 5α-reductase activity in genital skin fibroblast monolayers