The transcriptional repressor protein PRH interacts with the proteasome

Biochemical Journal

Volumn 374, Issue 3, 2003, Pages 667-675

  Bess, Kirstin L ^a   Swingler, Tracey E ^a   Rivett, A Jennifer ^a   Gaston, Kevin ^a   Jayaraman, Padma Sheela ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Haematopoiesis; Hex; Transcriptional repression

Indexed keywords

CELLS; COMPLEXATION; DNA;

BIOLOGICAL ROLES;

PROTEINS;

PROLINE RICH HOMEODOMAIN PROTEIN; PROTEASOME; REPRESSOR PROTEIN; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; HHEX PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; MONOCLONAL ANTIBODY; MULTIENZYME COMPLEX; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME SUBUNIT; GENE CONTROL; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; CELL CULTURE; CELL STRAIN K 562; CHEMISTRY; GEL MOBILITY SHIFT ASSAY; GENE LIBRARY; GENE VECTOR; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HYDROLYSIS; METABOLISM; SACCHAROMYCES CEREVISIAE; SERODIAGNOSIS; TWO HYBRID SYSTEM;

ANTIBODIES, MONOCLONAL; CYSTEINE ENDOPEPTIDASES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE LIBRARY; GENETIC VECTORS; HOMEODOMAIN PROTEINS; HUMANS; HYDROLYSIS; K562 CELLS; MULTIENZYME COMPLEXES; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0141567697     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030769     Document Type: Article

References (46)

1. Ferrell, K., Wilkinson, C. R., Dubiel, W. and Gordon, C. (2000) Regulatory subunit interactions of the 26 S proteasome, a complex problem. Trends Biochem. Sci. 25, 83-88
2. Ciechanover, A. (1998) The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J. 17, 7151-7160
3. Maki, C. G., Huibregtse, J. M. and Howley, P. M. (1996) In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res. 56, 2649-2654
4. Nawaz, Z., Lonard, D. M., Dennis, A. P., Smith, C. L. and O'Malley, B. W. (1999) Proteasome-dependent degradation of the human estrogen recepton. Proc. Natl. Acad. Sci. U.S.A. 96, 1858-1862
5. Chang, Y. C., Lee, Y. S., Tejima, T., Tanaka, K., Omura, S., Heintz, N. H., Mitsui, Y. and Magae, J. (1998) mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway. Cell Growth Differ. 9, 79-84
6. Ratner, J. N., Balasubramanian, B., Corden, J. Warren, S. L. and Bregman, D. B. (1998) Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair. J. Biol. Chem. 273, 5184-5189
7. Brown, M. S., Ye, J., Rawson, R. B. and Goldstein, J. L. (2000) Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell (Cambridge, Mass.) 100, 391-398
8. Ferdous, A., Gonzalez, F., Sun, L., Kodadek, T. and Johnston, S. A. (2001) The 19 S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II. Mol. Cells 7, 981-991
9. Makino, Y., Yoshida, T., Yogosawa, S., Tanaka, K., Muramatsu, M. and Tamura, T. A. (1999) Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120. Genes Cells 4, 529-539
10. Gonzalez, F., Delahodde, A., Kodadek, T. and Johnston, S. A. (2002) Recruitment of a 19 S proteasome subcomplex to an activated promoter. Science 296, 548-550
11. Salghetti, S. E., Muratani, M., Wijnen, H., Futcher, B. and Tansey, W. P. (2000) Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis. Proc. Natl. Acad. Sci. U.S.A. 97, 3118-3123
12. Molinari, E., Gilman, M. and Natesan, S. (1999) Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo. EMBO J. 18, 6439-6447
13. Salghetti, S. E., Caudy, A. A., Chenoweth, J. G. and Tansey, W. P. (2001) Regulation of transcriptional activation domain function by ubiquitin. Science 293, 1651-1653
14. Crompton, M. R., Bartlett, T. J., MacGregor, A. D., Manfioletti, G., Buratti, E., Giancotti, V. and Goodwin, G. H. (1992) Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. Nucleic Acids Res. 20, 5661-5667
15. Newman, C. S., Chia, F. and Krieg, P. A. (1997) The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number. Mech. Dev. 66, 83-93
16. Bedford, F. K., Ashworth, A., Enver, T. and Wiedemann, L. M. (1993) HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res. 21, 1245-1249
17. Tanaka, T., Inazu, T., Yamada, K., Myint, Z., Keng, V. W., Inoue, Y., Taniguchi, N. and Noguchi, T. (1999) cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein. Biochem. J. 339, 111-117
18. Guiral, M., Bess, K., Goodwin, G. and Jayaraman, P. S. (2001) PRH represses transcription in hematopoietic cells by at least two independent mechanisms. J. Biol. Chem. 276, 2961-2970
19. Pellizzari, L., D'Elia, A., Rustighi, A., Manfioletti, G., Tell, G. and Damante, G. (2000) Expression and function of the homeodomain-containing protein Hex in thyroid cells. Nucleic Acids Res. 28, 2503-2511
20. Brickman, J. M., Jones, C. M., Clements, M., Smith, J. C. and Beddington, R. S. (2000) Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function. Development 127, 2303-2315
21. Thomas, P. Q., Brown, A. and Beddington, R. S. (1998) Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 125, 85-94
22. Jones, C. M., Broadbent, J., Thomas, P. Q., Smith, J. C. and Beddington, R. S. (1999) An anterior signalling centre in Xenopus revealed by the homeobox gene XHex. Curr. Biol. 9, 946-954
23. Martinez Barbera, J. P., Clements, M., Thomas, P., Rodriguez, T., Meloy, D., Kioussis, D. and Beddington, R. S. (2000) The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development 127, 2433-2445
24. Jayaraman, P. S., Frampton, J. and Goodwin, G. (2000) The homeodomain protein PRH influences the differentiation of haematopoietic cells. Leuk. Res. 24, 1023-1031
25. Topcu, Z., Mack, D. L., Hromas, R. A. and Borden, K. L. (1999) The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene 18, 7091-7100
26. Topisirovic, I., Culjkovic, B., Cohen, N., Perez, J. M., Skrabanek, L. and Borden, K. L. (2003) The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of elF4E-dependent cyclin D1 mRNA transport and growth. EMBO J. 22, 689-703
27. Reference deleted
28. Fields, S. and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature (London) 340, 245-246
29. Butcher, A. J., Gaston, K. and Jayaraman, P.-S. (2003) Purification of the proline-rich homeodomain protein. J. Chromatogr. B 786, 3-6
30. Rivett, A. J., Savory, P. J. and Djaballah, H. (1994) Multicatalytic endopeptidase complex: proteasome. Methods Enzymol. 244, 331-350
31. Reidlinger, J., Pike, A. M., Savory, P. J., Murray, R. Z. and Rivett, A. J. (1997) Catalytic properties of 26 S and 20 S proteasomes and radiolabeling of MB1, LMP7, and C7 subunits associated with trypsin-like and chymotrypsin-like activities. J. Biol. Chem. 272, 24899-24905
32. Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 89, 5547-5551
33. Rihs, H. P. and Peters, R. (1989) Nuclear transport kinetics depend on phosphorylation-site-containing sequences flanking the karyophilic signal of the Simian virus 40 T-antigen. EMBO J. 8, 1479-1484
34. Gerards, W. L., de Jong, W. W., Bloemendal, H. and Boelens, W. (1998) The human proteasomal subunit HsC8 induces ring formation of other α-type subunits. J. Mol. Biol. 275, 113-121
35. Touitou, R., Richardson, J., Bose, S., Nakanishi, M., Rivett, J. and Allday, M. J. (2001) A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 α-subunit of the 20 S proteasome. EMBO J. 20, 2367-2375
36. Fan, C. M. and Maniatis, T. (1991) Generation of p50 subunit of NF-κB by processing of p105 through an ATP-dependent pathway. Nature (London) 354, 395-398
37. Hoppe, T., Matuschewski, K., Rape, M., Schlenker, S., Ulrich, H. D. and Jentsch, S. (2000) Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell (Cambridge. Mass.) 102, 577-586
38. Gerards, W. L., Enzlin, J., Haner, M., Hendriks, I. L., Aebi, U., Bloemendal, H. and Boelens, W. (1997) The human α-type proteasomal subunit HsC8 forms a double ringlike structure, but does not assemble into proteasome-like particles with the β-type subunits Hsδ or HsBPROS26. J. Biol. Chem. 272, 10080-10086
39. Javed, A., Guo, B., Hiebert, S., Choi, J. Y., Green, J., Zhao, S. C., Osborne, M. A., Stifani, S., Stein, J. L., Lian, J. B. et al. (2000) Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(α)/AML/PEBP2(α)) dependent activation of tissue-specific gene transcription. J. Cell Sd. 113, 2221-2231
40. Obinata, A., Akimoto, Y., Omoto, Y. and Hirano, H. (2002) Expression of Hex homeobox gene during skin development: increase in epidermal cell proliferation by transfecting the Hex to the dermis. Dev. Growth Differ. 44, 281-292
41. Zhong, S., Salomoni, P. and Pandolfi, P. P. (2000) The transcriptional role of PML and the nuclear body. Nat. Cell Biol. 2, E85-E90
42. Borden, K. L. (2002) Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies. Mol. Cell. Biol. 22, 5259-5269
43. Boddy, M. N., Duprez, E., Borden, K. L. and Freemont, P. S. (1997) Surface residue mutations of the PML RING finger domain alter the formation of nuclear matrix-associated PML bodies. J. Cell Sci. 110, 2197-2205
44. Chang, K. S., Fan, Y. H., Andreeff, M., Liu, J. and Mu, Z. M. (1995) The PML gene encodes a phosphoprotein associated with the nuclear matrix. Blood 85, 3646-3653
45. Lafarga, M., Berciano, M. T., Pena, E., Mayo, I., Castano, J. G., Bohmann, D., Rodrigues, J. P., Tavanez, J. P. and Carmo-Fonseca, M. (2002) Clastosome: a subtype of nuclear body enriched in 19 S and 20 S proteasomes, ubiquitin, and protein substrates of proteasome. Mol. Biol. Cell 13, 2771-2782
46. Lallemand-Breitenbach, V., Zhu, J., Puvion, F., Koken, M., Honore, N., Doubeikovsky, A., Duprez, E., Pandolfi, P. P., Puvion, E., Freemont, P. et al. (2001) Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11 S proteasome recruitment, and As203-induced PML or PML/retinoic acid receptor α degradation. J. Exp. Med. 193, 1361-1371