Substrate/inhibition studies of bacteriophage T7 RNA polymerase with the 5'-triphosphate derivative of a ring-expanded ('fat') nucleoside possessing potent antiviral and anticancer activities

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2931-2936

  Bretner, Maria ^a   Beckett, Dorothy ^a   Sood, Ramesh K ^b   Baldisseri, Donna M ^c   Hosmane, Ramachandra S ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b Nabi Biopharmaceuticals   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Antiviral anticancer activities; Biochemistry; Ring expanded ('fat') nucleoside nucleotide; Substrate inhibition studies; T7 RNA polymerase

Indexed keywords

4,6 DIAMINO 8 IMINO 8H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5E][1,3]DIAZEPINE; 4,6 DIAMINO 8 IMINO 8H 1 BETA DEXTRORIBOFURANOSYLIMIDAZO[4,5E][1,3]DIAZEPINE 5' TRIPHOSPHATE; NUCLEOSIDE; NUCLEOSIDE TRIPHOSPHATE; RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BACTERIOPHAGE T7; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME SUBSTRATE; GENETIC TRANSCRIPTION; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; AZEPINES; BASE SEQUENCE; DNA; DNA-DIRECTED RNA POLYMERASES; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOSIDES; NUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

EID: 0033392137     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00235-7     Document Type: Article

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