Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cells

Antiviral Research

Volumn 53, Issue 2, 2002, Pages 159-164

  Sood, Ramesh K ^a   Bhadti, Vishweshwar S ^a,d   Fattom, Ali I ^a   Naso, Robert B ^a   Korba, Brent E ^b   Kern, Earl R ^c   Chen, Huan Ming ^d   Hosmane, Ramachandra S ^d  

^a Nabi   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c University of Alabama at Birmingham and Children's Hospital   (United States)

^d UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

Human hepatoblastoma cell line; In vitro HBV inhibition; Low toxicity in stationary and fast growing cell systems; Ring expanded nucleoside analogs

Indexed keywords

4,6 DIAMINO 8H 8 IMINO 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5 E][1,3]DIAZEPINE; 5,6,7,8 TETRAHYDRO 4H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE 5,8 DIONE; 6 AMINO 4,5 DIHYDRO 8H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; 6 AMINO 4,5 DIHYDRO 8H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5E][1,3]DIAZEPINE 4,8 DIONE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; CELL CULTURE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; HEPATITIS B VIRUS; HEPATOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; HEPATITIS B; HEPATITIS B VIRUS; HEPATOBLASTOMA; HUMANS; LIVER NEOPLASMS; NUCLEOSIDES; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

HEPATITIS B VIRUS;

EID: 0036144534     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00204-2     Document Type: Article

References (19)

1. Overview on the epidemiology of hepatocellular carcinoma
2. The synthesis of novel ring-expanded xanthine nucleosides containing the 5:7-fused imidazo[4,5-e][1,2,4]triazepine ring system
3. Hepatitis B: Treatment for the 21st century
4. The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection
5. Cases of selected notifiable diseases
6. An efficient, short synthesis and potent anti-hepatitis B viral activity of 6-amino-8-hydroxy-4H-imidazo[4,5-e][1,3]diazepene-4-one: A novel ring-expanded purine nucleoside analogue containing a fused 5:7-fused, planer, aromatic, heterocyclic ring system
7. Use of 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus
8. Inhibition of the replication of the hepatitis B virus by 2′,3′-dideoxy-3′-thiacytidine and related analogs
9. Efficacy of the carbocyclic 2′-deoxyguanosine nucleoside BMS-200475 in woodchuck model of hepatitis B virus infection
10. Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus
11. Use of standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication
12. Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells
13. Synthesis and biological evaluation of 2′,3′-dideoxy-l-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV)
14. Antiviral activity of 2′,3′-dideoxy-β-l-5-fluorocytidine (β-l-FddC) and 2′,3′-dideoxy-β-l-cytidine (β-l-ddC) against hepatitis B virus and human immunodeficiency virus type1 in vitro
15. Inhibition of duch hepatitis virus replication by 9-(2-phosphonylmethoxyethyl)adenine, an acyclic phosphonate nucleoside analog
16. Comparison of cytotoxicity of the (-) and (+)-enatiomers of 2′3′-dideoxy-3′-thiacytidine in normal human bone marrow progenitor cells
17. A short synthesis of a novel ring expanded purine and its nucleoside analogue containing the imidazo[4,5-e][1,3]diazepene ring skeleton with multiple amino substituents attached to the seven membered ring
18. Inhibitory effects of selected compounds on humal hepatitis B virus DNA synthesis
19. Inhibition of replication of hepatitis B virus by cytalline in vitro