Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cells

Antiviral Research

Volumn 53, Issue 2, 2002, Pages 159-164

  Sood, Ramesh K ^a   Bhadti, Vishweshwar S ^a,d   Fattom, Ali I ^a   Naso, Robert B ^a   Korba, Brent E ^b   Kern, Earl R ^c   Chen, Huan Ming ^d   Hosmane, Ramachandra S ^d  

^a Nabi   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

Human hepatoblastoma cell line; In vitro HBV inhibition; Low toxicity in stationary and fast growing cell systems; Ring expanded nucleoside analogs

Indexed keywords

4,6 DIAMINO 8H 8 IMINO 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5 E][1,3]DIAZEPINE; 5,6,7,8 TETRAHYDRO 4H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE 5,8 DIONE; 6 AMINO 4,5 DIHYDRO 8H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; 6 AMINO 4,5 DIHYDRO 8H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5E][1,3]DIAZEPINE 4,8 DIONE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; CELL CULTURE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; HEPATITIS B VIRUS; HEPATOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; HEPATITIS B; HEPATITIS B VIRUS; HEPATOBLASTOMA; HUMANS; LIVER NEOPLASMS; NUCLEOSIDES; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

HEPATITIS B VIRUS;

EID: 0036144534     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00204-2     Document Type: Article

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