Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 21, 2003, Pages 3661-3663

  Vigushin, David M ^a   Brooke, Greg ^a   Willows, David ^b   Coombes, R Charles ^b   Moody, Christopher J ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETYLTHIO 9 METHOXY 2 METHYL 2,3 DIHYDROPYRAZINO[1,2 A]INDOLE 1,4 DIONE; DIMETHYLALLYLTRANSFERASE; FARNESYL TRANS TRANSFERASE; GLIOTOXIN; MYCOTOXIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PYRAZINO[1,2 A]INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN;

EID: 0141545133     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.022     Document Type: Article

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