X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 21, 2003, Pages 3871-3874

  Foley, Louise H ^a,c   Wang, Ping ^a   Dunten, Pete ^a,d   Ramsey, Gwendolyn ^b   Gubler, Mary Lou ^b   Wertheimer, Stanley J ^b  

^a HOFFMANN LA ROCHE INC   (United States)

^b Hoffman La Roche Department of Metabolic Diseases   (United States)

^c NONE   (United States)

^d ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; FUNCTIONAL GROUP; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) INHIBITOR; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; X RAY ANALYSIS;

EID: 0141545054     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00723-6     Document Type: Article

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