Modified 3-alkyl-1,8-dibenzylxanthines as GTP-competitive inhibitors of phosphoenolpyruvate carboxykinase

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 20, 2003, Pages 3607-3610

  Foley, Louise H ^a,c   Wang, Ping ^a   Dunten, Pete ^a   Ramsey, Gwendolyn ^b   Gubler, Mary Lou ^b   Wertheimer, Stanley J ^b  

^a HOFFMANN LA ROCHE INC   (United States)

^b Hoffman La Roche Department of Metabolic Diseases   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALLYL 3 BUTYL 8 METHYLXANTHINE; ANTIDIABETIC AGENT; GLUCOSE; GUANOSINE TRIPHOSPHATE DERIVATIVE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; CYTOSOL; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GLUCOSE HOMEOSTASIS; HUMAN; IN VITRO STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; STRUCTURE ACTIVITY RELATION;

EID: 0141786821     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00722-4     Document Type: Article

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