Molecular differences between small and large cells in patients with chronic lymphocytic leukemia

European Journal of Haematology

Volumn 71, Issue 4, 2003, Pages 235-242

  Lee, Jeong N ^a   Giles, Fancis ^a   Huh, Yang O ^a   Manshouri, Taghi ^a   O'Brien, Susan ^a   Kantarjian, Hagop M ^a   Keating, Michael J ^a   Albitar, Maher ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Bone marrow; CLL; Loss of heterozygosities; Richter's syndrome

Indexed keywords

ADULT; AGED; ARTICLE; ATM GENE; BONE MARROW CELL; CANCER PATIENT; CANCER SURVIVAL; CELL ISOLATION; CELL SIZE; CHROMOSOME 11; CHROMOSOME 17; CHROMOSOME 20; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DNA EXTRACTION; FEMALE; GENE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; LARGE CELL LYMPHOMA; LEUKEMIA CELL; MALE; MEGAKARYOCYTE; MOLECULAR BIOLOGY; PRIORITY JOURNAL; RICHTER SYNDROME; STATISTICAL SIGNIFICANCE; SURVIVAL RATE;

ADULT; AGED; CELL CYCLE PROTEINS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 20; CYTOGENETICS; DNA; DNA-BINDING PROTEINS; FEMALE; HUMANS; LASERS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LOSS OF HETEROZYGOSITY; MALE; MEGAKARYOCYTES; MICROSATELLITE REPEATS; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; SYNDROME; TUMOR SUPPRESSOR PROTEINS;

EID: 0141540369     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2003.00089.x     Document Type: Article

References (44)

1. O'BRIEN S, DEL GIGLIO A, KEATING M. Advances in the biology and treatment of B-cell chronic lymphocytic leukemia. Blood 1995;85:307-318.
2. KEATING MJ. Chronic lymphocytic leukemia. Semin Oncol 1999;26:107-114.
3. FOUCAR K, RYDELL RE. Richter's syndrome in chronic lymphocytic leukemia. Cancer 1979;46:118-134.
4. ROBERTSON LE, PUGH W, O'BRIEN S, KANTARJIAN H, HIRSCH-GINSBERG C, CORK A, MCLAUGHLIN P, CABANILLAS F, KEATING MJ. Richter's syndrome: a report on 39 patients. J Clin Oncol 1993;11:1985-1989.
5. GILES FJ, O'BRIEN S, KEATING MJ. Chronic lymphocytic leukemia in (Richter's) transformation. Semin Oncol 1998;25:117-125.
6. KODURU PR, LICHMAN SM, SMILARI TF, SUN T, GOH JC, KARP L, HALL W, HASHIMOTO S, CHIORAZZI N, BROOME JD. Serial phenotypic, cytogenetic and molecular genetic studies in Richter's syndrome: demonstration of lymphoma development from the chronic lymphocytic leukemia. Br J Haematol 1993;85:613-616.
7. HARRIS JE. Transformation of chronic lymphocytic leukemia to immunoblastic lymphoma (Richter's syndrome). Med Pediatr Oncol 1997;29:146-151.
8. MEDEIROS LJ, STETLER-STEVENSON HA. Composite B-cell and T-cell lymphoma. Coincidental occurrence or related neoplasm?. Am J Clin Pathol 1992;98:387-389.
9. FOON KA, THIRUVENGADAM R, SAVEN A, BERNSTEIN ZP, GALE RP. Genetic relatedness of lymphoid malignancies. Transformation of chronic lymphocytic leukemia as a model. Ann Intern Med 1993;119:63-73.
10. MATOLCSY A, INGHIRAMI G, KNOWLES DM. Molecular genetic demonstration of the diverse evolution of Richter's syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma. Blood 1994;83:1363-1372.
11. GAIDANO G, BALLERINI P, GON JZ, INGHIRAMI G, NERI A, NEWCOMB EW, MAGRATH IT, KNOWLES DM, DALLA-FAVERA R. R.p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1991;88:5413-5417.
12. INK4A genes are associated with Richter's syndrome (RS). Hematol Cell Ther 1997;39:65[abstract].
13. FENAUX P, PREUDHOMME C, LAI JL, QUIQUANDON I, JONVEAUX P, VANRUMBEKE M, SARTIAUX C, MOREL P, LOUCHEUX-LEFEBVRE MH, BAUTERS F. Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis. Leukemia 1992;6:246-250.
14. AMIEL A, ARBOV L, MANOR Y. Monoallelic p53 deletion in chronic lymphocytic leukemia detected by interphase cytogenetics. Cancer Genet Cytogenet 1997;97:97-100.
15. DIERLAMM J, MICHAUX L, CRIEL A, WLODARSKA I, VAN BERGHE den H, HOSSFELD DK. Genetic abnormalities in chronic lymphocytic leukemia and their clinical and prognostic implications. Cancer Genet Cytogenet 1997;94:27-35.
16. LENS D, De SCHOUWER PJ, HAMOUDI RA. p53 abnormalities in B-cell prolymphocytic leukemia. Blood 1997;89:2015-2023.
17. STILGENBAUER S, DOHNER K, BENTZ M, LICHTER P, DOHNER H. Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia. Ann Hematol 1998;76:101-100.
18. VOLPE G, GAMBERI B, PASTORE C, ROETTO A, PAUTASSO M, PARVIS G, CAMASCHELLA C, MAZZA U, SAGLIO G, GAIDANO G. Analysis of microsatellite instability in chronic lymphoproliferative disorders. Ann Hematol 1996;72:67-71.
19. STAROSTIK P, MANSHOURI T, O'BRIEN S, FREIREICH E, KANTARJIAN H, HAIDAR M, LERNER S, KEATING M, ALBITAR M. Deficiency of the ATM protein expression defines an aggressive subgroup of B-cell chronic lymphocytic leukemia. Cancer Res 1998;58:4552-4557.
20. SCHAFFNER C, STILGENBAUER S, RAPPOLD GA, DOHNER H, LICHTER P. Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. Blood 1999;94:748-753.
21. AUER RL, JONES C, MULLENBACH RA, SYNDERCOMBE-COURT D, MILLIGAN DW, FEGAN CD, COTTER FE. Role for CCG-trinucleotide repeats in the pathogenesis of chronic lymphocytic leukemia. Blood 2001;97:509-515.
22. BONNER RF, EMMERT-BUCK M, COLE K, POHIDA T, CHUAQUI R, GOLDSTEIN S, LIOTTA LA. Laser capture microdissection: molecular analysis of tissue. Science 1997;278:1481-1483.
23. SUAREZ-QUIAN CA, GOLDSTEIN SR, POHIDA T, SMITH PD, PETERSON JI, WELLNER E, GHANY M, BONNER RF. Laser capture microdissection of single cells from complex tissue. Biotechniques 1999;26:328-335.
24. MILCHGRUB S, WISTUBA I, KIM BK, RUTHERFORD C, URBAN J, CRUZ PD, Jr, GAZDAR AF. Molecular identification of metastatic cancer to the skin using laser capture microdissection. Cancer 2000;88:749-754.
25. JULIUSSON G, OSCIER D, GAHRTON G for the International Working Party on Chromosomes in CLL (IWCCLL). Cytogenetic finding and survival in B-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients. Luk Lymphoma 1991;5:21-25.
26. KIPPS TJ. Genetics of chronic leukemia. Hematol Cell Ther 2000;42:5-14.
27. DOHNER H, STILGENBAUER S, DOHNER K, BENTZ M, LICHTER P. Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis. J Mol Med 1999;77:266-281.
28. BEA S, LOPEZ-GUILLERMO A, RIBAS M, PUIG X, PINYOL M, CARRIO A, ZAMORA L, SOLER F, BOSCH F, STILGENBAUER S, COLOMER D, MIRO R, MONTSERRAT E, CAMPO E. Related Articles, Links Abstract Genetic imbalances in progressed B-cell chronic lymphocytic leukemia and transformed large-cell lymphoma (Richter's syndrome). Am J Pathol. 2002;161:957-968.
29. DAVIS MP, DEWALD GW, PIERRE RV, HOAGLAND HC. Hematologic manifestations associated with deletions of the long arm of chromosome 20. Cancer Genet Cytogenet 1984;12:63-71.
30. KURTIN PJ, DEWALD GW, SHIELDS DJ, HANSON CA. Hematologic disorders associated with deletions of chromosome 20q. Am J Clin Pathol 1996;106:680-688.
31. AATOLA M, ARMSTRONG E, TEERENHOVI L, BORGSTROM GH. Clinical significance of the del(20q) in hematologic disorders. Cancer Genet Cytogenet 1992;62:75-80.
32. MORI N, MOROSETTI R, HOFLEHNER E, LUBBERT M, MIZOGUCHI H, KOEFFLER HP. Allelic loss in progression of myelodysplastic syndrome. Cancer Res 2000;60:3039-3042.
33. ROULSTON D, ESPINOSA R III, STOFFEL M, BELL GI, LE BEAU MM. Molecular genetics of myeloid leukemia: identification of the commonly deleted segment of chromosome 20. Blood 1993;82:3424-3429.
34. WANG PW, IANNATUONI K, DAVIS EM, ESPINOSA R, III, STOFFEL M, LE BEAU MM. Refinement of the commonly deleted segment in myeloid leukemias with a del(20q). Genes Chromosomes Cancer 1998;21:75-81.
35. COUQUE N, CHAMBON-PAUTAS C, CAVE H, BARDET V, DUVAL M, VILMER E, GRANDCHAMP B. Mapping of chromosome 20q for loss of heterozygosity in childhood ALL reveals a 1000-kb deletion in one patient. Leukemia 1999;13:1972-1974.
36. HOLLINGS PE, BENJES SM, ROSMAN I, FITZGERALD PH. Deletion 20q in association with Philadelphia chromosome positive acute lymphoblatic leukemia. Cancer Genet Cytogenet 1995;79:32-35.
37. LAVIN MF, SHILOH Y. The genetic defect in ataxia-telangiectasia. Annu Rev Immunol 1997;15:177-182.
38. JEGGO PA, CARR AM, LEHMANN AR. Splitting the ATM: distinct repair and checkpoint defects in ataxia telangiectasia. Trends Genet 1998;14:312-318.
39. STANKOVIC T, KIDD AMJ, SUTCLIFFE A, MCGUIRE GM, ROBINSON P, WEBER P, BEDENHAM T, BRADWELL AR, EASTON DF, LENNOX GG, HAITES N, BYRD PJ, TAYLOR AM. ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer. Am J Hum Genet 1998;62:334-345.
40. FEGAN C, ROBINSON H, THOMPSON P. Karyotypic evolution in CLL: identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease. Leukemia 1995;9:2003-2008.
41. DOHNER H, STILGENBAUER S, JAMES MR, BENNER A, WEILGUNI T, BENTZ M, FISCHER K, HUNSTEIN W, LICHTER P. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 1997;89:2516-2522.
42. BULLRICH F, RASIO D, KITADA S, STAROSTIK P, KIPPS T, KEATING M, ALBITAR M, REED JC, CROCE CM. ATM mutations in B-cell chronic lymphocytic leukemia. Cancer Res 1999;59:24-27.
43. BEVAN S, YUILLE MR, MAROSSY A, CATOVSKY D, HOUSTON RS. Ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukemia. Lancet 1999;353:26-29.
44. HAIDAR MA, KANTARJIAN H., MANSHOURI T, CHANG CY, O'BRIEN S, FREIREICH E, KEATING M, ALBITAR M. ATM gene deletion in patients with adult acute lymphoblastic leukemia. Cancer 2000;88:1057-1062.