A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: Involvement of CGRP, NO, cGMP, and endothelium-dependent activities

Journal of Cardiovascular Pharmacology

Volumn 42, Issue 4, 2003, Pages 511-520

  Lo, Yi Ching ^a   Hsiao, Hui Chuan ^a   Wu, Deng Chyang ^a   Lin, Rong Jyh ^a   Liang, Jhy Chong ^a   Yeh, Jwu Lai ^a   Chen, Ing Jun ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

CGRP; Cyclic GMP; K+ channel; Nitric oxide; VOA

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN DERIVATIVE; CAPSAZEPINE; CYCLIC GMP; GLIBENCLAMIDE; METHYLENE BLUE; N [4 O (2 METHOXYPHENOXYETHYLAMINOBUTYL) 3 METHOXYBENZYL]NONAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; POTASSIUM; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTERY ENDOTHELIUM; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; HEART RATE; HUMAN; HYPERTENSION; IMMUNOREACTIVITY; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; UMBILICAL VEIN; VASCULAR SMOOTH MUSCLE; VASODILATATION; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CELLS, CULTURED; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; HYPERTENSION; MESENTERIC ARTERIES; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNELS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; UMBILICAL ARTERIES; VASODILATION; VASODILATOR AGENTS;

EID: 0141530891     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200310000-00009     Document Type: Article

References (36)

1. Rubino A, Burnstock G. Capsaicin-sensitive sensory-motor neurotransmission in the peripheral control of cardiovascular function. Cardiovasc Res. 1996;31:467-479.
2. Arnold WP, Mittal CK, Katsuki S, et al. Nitric oxide activates guanylate cyclase and increases guanosine 3′, 5′-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci USA. 1997;74:3203-3207.
3. Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiology messenger. Ann Intern Med. 1994;120:227-237.
4. Ohmura T, Nashio M, Kigoshi S, et al. Electrophysiological and mechanical effects of calcitonin gene-related peptide on guinea-pig atria. Br J Pharmacol. 1990;100:27-30.
5. + channels. Nature. 1990;344:770-773.
6. Yoshimoto R, Mitsui-Saito M, Ozaki H, et al. Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery. Br J Pharmacol. 1998;123:1645-1654.
7. Brain SD, Williams TJ, Tippins JR, et al. Calcitonin gene-related peptide is a potent vasodilator. Nature. 1985;313:54-56.
8. Asimakis GK, Dipette DJ, Conti VR, et al. Hemodynamic action of calcitonin gene-related peptide immunoreactivity in the spinal cord of man and eight other species. Hypertension. 1978;9:142-146.
9. Dipette DJ, Schwarzenberg K, Kerr N, et al. Dose dependent systemic and regional hemodynamic effects of calcitonin gene-related peptide. Am J Med Sci. 1998;297:65-70.
10. Chen IJ, Yang JM, Yeh JL, et al. Hypotensive and antinociceptive effects of ether-linked and relatively non-pungent analogues of N-nonanoyl vanillylamide. Eur J Med Chem. 1992;27:187-192.
11. Chen IJ, Yeh JL, Lo YC, et al. Capsinolol: the first β-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart. Br J. Pharmacol. 1996;119:7-14.
12. Franco-Cereceda A. Calcitonin gene-related peptide and tachykinins in relation to local sensory control of cardiac contractility and coronary vascular tone. Acta Physiol Scand. 1988;133:1-63.
13. + channel opening and vasorelaxant properties. J Pharmacol Exp Ther. 1997;281:253-260.
14. 1-adrenoceptor antagonist with α-adrenoceptor blocking and potassium channel opening activities. Drug Dev Res. 2002;55:104-117.
15. Yeh JL, Wu JR, Chiu CC, et al. Vanillylamide-based propanolamine derivative displays α/β-adrenoceptor blocking and vasodilating properties. J Cardiovasc Pharmacol. 2002;39:803-813.
16. G-nitro-L-arginine methyl ester-induced hypertension during pregnancy. Hypertension. 1997;29:248-253.
17. Mulvany MJ, Nilsson H, Flatman JA. Role of membrane potential in the response of rat small mesenteric arteries to exogeneous noradrenalin stimulation. J Physiol (Lond). 1982;332:363-373.
18. Feleder EC, Adler-Graschinsy E. Endothelium-mediated and N-nitro-L-arginine methyl ester-sensitive responses to cromakalim and diazoxide in the rat mesenteric bed. Eur J Pharmacol. 1997;319:229-238.
19. + channel opening activities in rat aortic smooth muscle. Br J Pharmacol. 2001;134:265-274.
20. + permeability. J Pharmacol Exp Ther. 1988;245:751-760.
21. Fouda AK, Kaufmann A, Thorin E, et al. The role of endogenous norepinephrine release in potassium evoked vasoconstriction of the rat tail artery. Eur J Pharmacol. 1991;205:63-72.
22. 1 kinin receptor expression and pharmacology I endothelial cells of different origin and species. J Pharmacol Exp Ther. 1997;280:1109-1116.
23. Wohlfart P, Malinski T, Ruetten H, et al. Release of nitric oxide from endothelial cell stimulated by YC-1, an activator of soluble guanylyl cyclase. Br J Pharmacol. 1999;128:1316-1322.
24. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
25. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some application. Proc Natl Acad Sci U S A. 1979;76:4350-4354.
26. Kawasaki H, Takasaki K, Saito A, et al. Calcitonin gene-related peptide acts as novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature. 1988;335:164-167.
27. Vanhoutte PM, Luscher TF. Peripheral mechanisms in cardiovascular regulation: transmitter, receptors and the endothelium. In: Tarazi RC, Zanchetti A, eds. Handbook of Hypertension: Physiology and Pathophysiology of Hypertension, Volume 8: Regulatory Mechanism. Amsterdam: Elsevier Science Publisher, 1986:96-123.
28. Grace GC, Dusting GJ, Kemp BE, et al. Endothelium and the vasodilator action of rat calcitonin gene-related peptide (CGRP). Br J Pharmacol. 1987;91:729-733.
29. Takenaga M, Kawasaki H, Wada A, et al. Calcitonin gene-related peptide mediates acetylcholine-induced endothelium-independent vasodilation in mesenteric resistance blood vessels of the rat. Cir Res. 1995;76:935-941.
30. Zygmunt PM, Ryman T, Hogestatt ED. Regional differences in endothelium-dependent relaxation in the rat: contribution of nitric oxide and nitric oxide-independent mechanisms. Acta Physiol Scand. 1995;155:257-266.
31. Wimalawansa SJ. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev. 1996;17:533-585.
32. + channels in cultured vascular smooth muscle. Cir Res. 1993;74:471-476.
33. Archer SL, Huang JMC, Hampel V, et al. Nitro oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1994;91:7583-7587.
34. Murphy ME, Brayden JE. Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels. J Physiol. (Lond) 1995;486:47-58.
35. + channels. Proc Natl Acad Sci U S A. 1996;93:10489-10494.
36. Castro AF, Amorena C, Muller A, et al. Extracellular ATP and bradykinin increase cGMP in vascular endothelial cells via activation of PKC. Am J Physiol. 1998;275:113-119.