Vanillylamide-based propanolamine derivative displays α/β-adrenoceptor blocking and vasodilating properties

Journal of Cardiovascular Pharmacology

Volumn 39, Issue 6, 2002, Pages 803-813

  Yeh, Jwu Lai ^a   Wu, Jiunn Ren ^a   Chiu, Chaw Chi ^a   Chen, Yea Wen ^a   Lo, Yi Ching ^a   Lin, Young Tso ^a   Cheng, Chang Jenq ^a   Chen, Ing Jun ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adrenoceptor blockade; Capsaicin derivative; K+ channels; Radioligand binding assay; Vasorelaxant activity

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CAPSAICIN DERIVATIVE; KMUP 880602; LABETALOL; PROPANOLAMINE DERIVATIVE; PROPRANOLOL;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR EFFECT; GUINEA PIG; HEMODYNAMIC MONITORING; INTRINSIC SYMPATHOMIMETIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; MALE; PROPANOLAMINES; RATS; RATS, WISTAR; VANILLIC ACID; VASODILATOR AGENTS;

EID: 0036102979     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200206000-00005     Document Type: Article

References (25)

1. Guaiacoxypropanolamine derivatives of capsaicin: A new family of β-adrenoceptor blockers with intrinsic cardiotonic properties
2. Capsinolol: The first βadrenoceptor blocker with an associated calcitonin generelated peptide releasing activity in the heart
3. 2-agonist activity derived from ferulic acid, an active component of Ligusticum wallichii Franch
4. 1-adrenoceptor antagonist with tracheal and vascular smooth muscle relaxant properties
5. 2-adrenoceptor agonist associated vasorelaxant activities
6. 2-agonist activity
7. Labedipinedilol-A: A vanilloid-based α/β-adrenoceptor blocker with calcium entry blocking and long-acting antihypertensive properties
8. Vanidipinedilol: A vanilloid-based β-adrenoceptor blocker displaying calcium entry blocking and vasorelaxant activities
9. Isoeugenodilol: A vasorelaxant α/β-adrenoceptor blocker with antioxidant activities
10. Pharmacological effects of an aldehyde type α/β-adrenoceptor blocking agent with vasodilating properties
11. Third-generation dihydropyridine-type calcium channel blocker labedipinedilol-B displays α/β-adrenoceptor blocking activities
12. The effects of calcitonin gene-related peptide on tracheal smooth muscle of guinea-pigs in vitro
13. Pathophysiologic and pharmacologic rationales for clinical management of chronic heart failure with beta-blocking agents
14. Improvement in cardiac myocyte function by biological effects of medical therapy: A new concept in the treatment of heart failure
15. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
16. Stimulant and depressant effects of β-adrenoceptor blocking agents on isolated heart muscle: A positive inotropic effect not mediated through adrenoceptors
17. Negative inotropic effects and the hydrophobicity of beta-adrenergic blocking agents
18. Sensory effects of capsaicin congeners. I. Relationship between chemical structure and pain-producing potency of pungent agents
19. Sensory effects of capsaicin congeners. II. Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds
20. Nitrated nonivamide displaying a drawback of proton's role in capsaicin-associated sensory and neuronal activities
21. The effects of a series of capsaicin analogues on nociception and body temperature in the rat
22. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels
23. Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone
24. Inositol triphosphate and calcium signalling
25. Myosin phosphorylation in smooth and skeletal muscles: Regulation and function