Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase

British Journal of Pharmacology

Volumn 128, Issue 6, 1999, Pages 1316-1322

  Wohlfart, Paulus ^a,c   Malinski, Tadeusz ^b   Ruetten, Hartmut ^a   Schindler, Ursula ^a   Linz, Wolfgang ^a   Schoenafinger, Karl ^a   Strobel, Hartmut ^a   Wiemer, Gabriele ^a  

^a SANOFI   (France)

^b OAKLAND UNIVERSITY   (United States)

^c Disease Group   (Germany)

Author keywords

Calcium; Endothelial cells; Guanosine 3',5' cyclic monophosphate (cyclic GMP); Nitric oxide; Relaxation; Soluble guanylyl cyclase; YC 1

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; 8 BROMO CYCLIC GMP; CALCIMYCIN; CALCIUM; CYCLIC GMP; GUANYLATE CYCLASE ACTIVATOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECOMBINANT ENZYME;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTERY DILATATION; ARTICLE; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UMBILICAL VEIN;

EID: 0032734962     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702921     Document Type: Article

References (21)

1. FRIEBE, A. & KOESLING, D. (1998). Mechanism of YC-1-induced activation of soluble guanylyl cyclase. Mol. Pharmacol., 53, 123-127.
2. FRIEBE, A., MULLERSHAUSEN, F., SMOLENSKI, A., WALTER, U., SCHULTZ, G. & KOESLING, D. (1998a). YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets. Mol. Pharmacol., 54, 962-967.
3. FRIEBE, A., SCHULTZ, G. & KOESLING, D. (1996). Sensitizing soluble guanylyl cyclase to become a highly CO- sensitive enzyme. EMBO J., 15, 6863-6868.
4. FRIEBE, A., SCHULTZ, G. & KOESLING, D. (1998b). Stimulation of soluble cyclase by superoxide dismutase is mediated by NO. Biochem. J., 335, 527-531.
5. GIUILI, G., ROECHEL, N., SCHOLL, U., MATTEI, M.G. & GUELLAEN, G. (1993). Colocalization of the genes coding for the alpha-3 & beta-3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33. Hum. Genet., 91, 257-260.
6. GIUILI, G., SCHOLL, U., BULLE, F. & GUELLAEN, G. (1992). Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. FEBS Lett., 304, 83-88.
7. HADOKE, P.W., WADSWORTH, R.M. & WAINWRIGHT, C.L. (1993). Characterization of the responses of isolated rings of rabbit left carotid artery. A potential protocol for the assessment of pathologically induced functional changes. J. Pharmacol. Toxicol. Methods., 29, 195-202.
8. HOENICKA, M., BECKER, E.M., APELER, H., SIRICHOKE, T., SCHRODER, H., GERZER, R. & STASCH, J.P. (1999). Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide. J. Mol. Med., 77, 14-23.
9. JIA, L & FURCHGOTT, R.F. (1993). Inhibition by sulfhydryl compounds of vascular relaxation induced by nitric oxide and endothelium-derived relaxing factor. J. Pharmacol. Exp. Ther., 267, 371-378.
10. KO, F.N., WU, C.C., KUO, S.C., LEE, F.Y. & TENG, C.M. (1994). YC-1, a novel activator of platelet guanylate cyclase. Blood, 84, 4226-4233.
11. KOESLING, D. (1998). Modulators of soluble guanylyl cyclase. Naunym-Schmiedeberg's Arch. Pharmacol., 358, 123-126.
12. MALINSKI, T. & TAHA, Z. (1992). Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor. Nature, 358, 676-678.
13. MULSCH, A., BAUERSACHS, J., SCHAFER, A., STASCH, J.P., KAST, R. & BUSSE, R. (1997). Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. Br. J. Pharmacol., 120, 681-689.
14. RUSSWURM, M., BEHRENDS, S., HARTENECK, C. & KOESLING, D. (1998). Functional properties of a naturally occuring isoform of soluble guanylyl cyclase. Biochem. J., 335, 125-130.
15. TENG, C.M., WU, C.C., KO, F.N., LEE, F.Y. & KUO, S.C. (1997). YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice. Eur. J. Pharmacol., 320, 161-166.
16. WEGENER, J.W., GATH, I., FORSTERMANN, U. & NAWRATH, H. (1997). Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat. Br. J. Pharmacol., 122, 1523-1529.
17. WIEMER, G., PIERCHALA, B., MESAROS, S., SCHOLKENS, B.A. & MALINSKI, T. (1996). Direct measurement of nitric oxide release from cultured endothelial cells stimulated by bradykinin or ramiprilat. Endothelium J. Endothelial. Cell Res., 4, 119-125.
18. WOHLFART, P., DEDIO, J., WIRTH, K., SCHOLKENS, B.A. & WIEMER, G. (1997). Different B1 kinin receptor expression and pharmacology in endothelial cells of different origins and species. J. Pharmacol. Exp. Ther., 280, 1109-1116.
19. WU, C.C., KO, F.N., KUO, S.C., LEE, F.Y. & TENG, C.M. (1995). YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br. J. Pharmacol., 116, 1973-1978.
20. YOSHINA, S. & KUO, S.C. (1978). Studies on heterocyclic compounds XXXV. Synthesis of furo[3,2-C]pyrazole derivatives. (2) electrophilic substitution of 1,3-diphenylfuro[3,2-C]pyrazole. Yakugaku Zasshi, 98, 204-208.
21. ZABEL, U., WEEGER, M., LA, M. & SCHMIDT, H.H H.W. (1998). Human soluble guanylate cyclase: functional expression and revised isoenzyme family. Biochem. J., 335, 51-57.