Improving selection of αIIbβ3-binding phage antibodies with increased reactivity derived from immunized donors

Clinical Immunology

Volumn 108, Issue 3, 2003, Pages 199-210

  Jacobin, M J ^a   Robert, R ^b   Pouns, O ^a   Laroche Traineau, J ^d   Nurden, A ^a   Peter, K ^e   Little, M ^c   Clofent Sanchez, G ^a,b  

^a HAUT LÉVÊQUE HOSPITAL   (France)

^b CNRS University Bordeaux Segalen   (France)

^c Affimed GmbH   (Germany)

^d University Victor Segalen   (France)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Antibody library; Autoimmune thrombocytopenic purpura; Autoimmunity; Gene rearrangement; Glanzmann thrombasthenia; Human antibodies; Integrin IIb 3; Phage display selection; Recombinant antibodies; scFv; Somatic mutation

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN G; LEVOTHYROXINE; STEROID; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; AUTOANTIBODY; FIBRINOGEN RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; OLIGOPEPTIDE; PEPTIDE LIBRARY;

ADULT; ARTICLE; BACTERIOPHAGE; CASE REPORT; ELUTION; FEMALE; GENE LIBRARY; GENE MUTATION; GLANZMANN DISEASE; HASHIMOTO DISEASE; HEART MUSCLE ISCHEMIA; HUMAN; IMMUNIZATION; IMMUNOREACTIVITY; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; SPLEEN CELL; THROMBOCYTOPENIC PURPURA; ANIMAL; CELL CLONE; CHO CELL; COMPLEMENTARITY DETERMINING REGION; CYTOLOGY; DONOR; GENETICS; HAMSTER; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOLOGY; MIDDLE AGED; MUTATION; SOMATIC HYPERMUTATION; SPLEEN;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; CHO CELLS; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; CRICETINAE; FEMALE; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MALE; MIDDLE AGED; MUTATION; OLIGOPEPTIDES; PEPTIDE LIBRARY; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SPLEEN; THROMBASTHENIA; TISSUE DONORS;

EID: 0141519091     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6616(03)00143-8     Document Type: Article

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