Light chain-restricted autoantibodies in chronic idiopathic thrombocytopenic purpura, but no evidence for circulating clonal B-lymphocytes

Annals of Hematology

Volumn 72, Issue 1, 1996, Pages 29-34

  Stockelberg, D ^a   Hou, M ^a   Jacobsson, S ^a   Kutti, J ^a   Wadenvik, H ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autoantibodies; B cells; Clonality; Idiopathic thrombocytopenic purpura; MAIPA

Indexed keywords

AUTOANTIBODY; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB; GLYCOPROTEIN IIIA; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

ADOLESCENT; ADULT; AGED; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOGLOBULIN GENE; LEUKOCYTE COUNT; LYMPHOCYTE CLONE; LYMPHOCYTE COUNT; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; THROMBOCYTE COUNT;

EID: 0030058692     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00663013     Document Type: Article

References (36)

1. Agrawal YP, Hamälainen E, Mahlamäki EK, Aho H, Nousiainen T, Lahtinen R, Penttilä IM (1992) Comparison of poly- and monoclonal antibodies for determination of B-cell clonal excess in a routine clinical laboratory. Eur J Haematol 48:49-55
2. Beardsley DS, Spiegel JE, Jacobs MM, Handin RI, Lux SE (1984) Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. J Clin Invest 74:1701-1707
3. Billadeau D, Blackstadt M, Greipp P, Kyle RA, Oken MM, Kay N, van Ness B (1991) Analysis of B-lymphoid malignancies using allele-specific polymerase chain reaction: a technique for sequential quantitation of residual disease. Blood 78:3021-3029
4. Brisco MJ, Tan LW, Orsborn AM, Morley AA (1990) Development of a highly sensitive assay, based on the polymerase chain reaction, for rare B-lymphocyte clones in a polyclonal population. Br J Haematol 75:163-167
5. Carson DAN, Chen PP, Kipps TJ, Radoux V, Jirik FR, Goldfien RD, Fox RJ, Silverman GJ, Fong S (1987) Idiotypic and genetic studies of human rheumatoid factors. Arthritis Rheum 30:1321-1325
6. Christie DJ, Sauro SC, Fairbanks KD, Kay NE (1993) Detection of clonal platelet antibodies in immunologically mediated thrombocytopenias: association with circulating clonal/ oligoclonal B cells. Br J Haematol 85:277-284
7. van der Harsi D, de Jong D, Limpens J, Kluin PhM, Rozier Y, van Ommen GJB, Brand A (1990) Clonal B-cell populations in patients with idiopathic thrombocytopenic purpura. Blood 76:2321-2326
8. Hewitt J, Burton IE (1994) Incidence of autoantibodies to GPIIb/IIIa in chronic autoimmune thrombocytopenic purpura may be overestimated by the MAIPA. Br J Haematol 86:418-420
9. Hiruiwa A, Nugent D, Miller ECB (1990) Sequence analysis of monoclonal antibodies derived from a patient with idiopathic thrombocytopenic purpura. Autoimmunity 8:107-113
10. Hymes KB, Karpatkin S (1990) In vitro suppressor T lymphocyte dysfunction in autoimmune thrombocytopenic purpura associated with a complement-fixing antibody. Br J Haematol 74:330-335
11. Johnson A, Olofsson T (1993) Flow cytometric clonal excess analysis of peripheral blood, routine handling, and pitfalls in interpretation. Cytometry 14:188-195
12. Kekomaki R, Dawson B, McFarland J, Kunicki TJ (1991) Localization of human platelet autoantigens to the cystein-rich region of glycoprotein IIIa. J Clin Invest 88:847-854
13. Kiefel V, Santoso S, Weisheit M, Mueller-Eckhardt C (1987) Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies. Blood 70:1722-1726
14. Kiefel V, Santoso S, Kaufmann E, Mueller-Eckhardt C (1991) Autoantibodies against platelet glycoprotein Ib/lX: a frequent finding in autoimmune thrombocytopenic purpura. Br J Haematoi 79:256-262
15. Kiefel V, Mueller-Eckhardt C (1993) Report on the Fifth International Society of Blood Transfusion Platelet Serology Workshop. Transfusion 33:65-69
16. Lauria F, Mantovani V, Catosky D, Gaurini A, Gugliotta L, Mirone E, Tura S (1981) T gamma cell deficiency in idiopathic thrombocytopenic purpura (ITP). Scand J Haematol 26:156-160
17. Lauria F, Raspadori D, Gobbi M, Gaurini A, Gugliotta L, Aieta M, Tura S (1983) T-cell subsets defined by monoclonal antibodies in autoimmune thrombocytopenic purpura (ATP). Haematologica (Pavia) 68:600-606
18. van Leeuwen EFJ, van der Ven th M, Engelfreit CP, von dem Borne AEGK (1982) Specificity of autoantibodies in autoimmune thrombocytopenia. Blood 59:23-26
19. Loken MR, Brosnan JM, Bach BA, Ault KA (1990) Establishing optimal lymphocyte gates for immunophenotyping by flow cytometry. Cytometry 11:453-459
20. Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from nucleated cells. Nucleic Acids Res 16:1215-1218
21. Misutani H, Katagiri S, Uejima K, Ohnishi M, Tamaki T, Kanayama Y, Tsubakio T, Kurata Y, Yonezawa T, Tarui S (1985) T-cell abnormalities in patients with idiopathic thrombocytopenic purpura: the presence of OKT4+8+ cells. Scand J Haematol 35:233-239
22. Mylvaganan R, Ahn YS, Harrington WJ, Kim CL, Gratzner HG (1985) Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura. Blood 66:967-972
23. Nugent DJ (1989) Human monoclonal antibodies in the characterization of platelet antigens. In: Kunicki TJ, George JN (eds) Platelet immunobiology: molecular and clinical aspects. Lippincott, Philadelphia, pp 273
24. Peller S, Kaufman S, Shaked U (1986) Immuno-regulatory defect in patients with autoimmune thrombocytopenic purpura (ATP). Thymus 8:361-367
25. Scott CS, Wheeler R, Ford P, Bynoe AG, Roberts BE (1983) T lymphocyte subpopulations in idiopathic thrombocytopenic purpura (ITP). Scand J Haematol 40:401-406
26. Semple JW, Freedman J (1991) Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood 78:2619-2625
27. Semple JW, Freedman J (1992) Cellular immune mechanisms in chronic autoimmune thrombocytopenic purpura (ATP). Autoimmunity 13:311-319
28. Silberstein LE, Jefferies LC, Goldman J, Friedman D, Moore JS, Nowell PC, Roelcke D, Pruzanski W, Roudier J, Silverman GC (1991) Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood 78:2372-2386
29. Sthoeger ZM, Sthoeger D, Shtalrid M, Sigler E, Geltner D, Berrebi A (1993) Mechanism of autoimmune hemolytic anemia in chronic lymphocytic leukemia. Am J Hematol 43:259-264
30. Stockelberg D, Jacobsson S, Kutti J, Wadenvik H (1995) Evidence for a light chain restriction of glycoprotein Ib/IX and IIb/IIIa reactive autoantibodies in chronic immune thrombocytopenic purpura. Br J Haematol 90:175-179
31. Szatkowski NS, Kunicki TJ, Aster RH (1986) Identification of glycoprotein Ib as a target for autoantibody in idiopathic (autoimmune) thrombocytopenic purpura. Blood 67:310-315
32. Trainor KJ, Brisco MJ, Colin JS, Alexander AM (1990) Monoclonality in B-lymphoproliferative disorders detected at the DNA level. Blood 11:2220-2222
33. Trent R, Adams E, Erhardt C, Basten A (1981) Alterations in T-gamma cells in patients with chronic idiopathic thrombocytopenic purpura. J Immunol 127:621-626
34. Varon D, Karpatkin S (1983) A monoclonal anti-platelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets. Proc Natl Acad Sci USA 80:6992-6995
35. Woods VL, Oh E, Mason D, McMillan R (1984) Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP. Blood 63:368-375
36. Woods VL, Kurata Y, Montgomery RR, Tani P, Mason D, Oh E, McMillan R (1984) Autoantibodies against platelet glycoprotein Ib in patients with chronic immune thrombocytopenic purpura. Blood 64:156-160