Inhibition of bleomycin-induced cell death in rat alveolar macrophages and human lung epithelial cells by ambroxol

Biochemical Pharmacology

Volumn 66, Issue 7, 2003, Pages 1297-1306

  Hong, Jun Sik ^a   Ko, Hyun Hee ^a   Han, Eun Sook ^a   Lee, Chung Soo ^a  

^a Chung Ang University   (South Korea)

Author keywords

Alveolar macrophages; Ambroxol; Bleomycin; Cell death; Lung epithelial cells; Mitochondrial membrane permeability

Indexed keywords

AMBROXOL; BLEOMYCIN; CARBONYL DERIVATIVE; CASPASE 3; CYTOCHROME C; GLUTATHIONE; HYDROXYL RADICAL; IRON; MALONALDEHYDE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL NUCLEUS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; EXPOSURE; HUMAN; HUMAN CELL; LIVER MITOCHONDRION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0141517635     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00448-9     Document Type: Article

References (50)

1. Jules-Elyse K., White D.A. Bleomycin-induced pulmonary toxicity. Clin. Chest Med. 11:1990;1-20.
2. Laskin D.L., Pendino K.J. Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol. 35:1995;655-677.
3. Yamazaki C., Hoshino J., Sekiguchi T., Hori Y., Miyauchi S., Mizuno S., Horie K. Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model. Jpn. J. Pharmacol. 78:1998;69-73.
4. Chandler D.B. Possible mechanisms of bleomycin-induced fibrosis. Clin. Chest Med. 11:1990;21-30.
5. Desai V.G., Casciano D., Feuers R.J., Aidoo A. Activity profile of glutathione-dependent enzymes and respiratory chain complexes in rats supplemented with antioxidants and treated with carcinogens. Arch. Biochem. Biophys. 394:2001;255-264.
6. Beinert T., Binder D., Stuschke M., Jorres R.A., Oehm C., Fleischhacker M., Sezer O., Mergenthaler H.G., Werner T., Possinger K. Oxidant-induced lung injury in anticancer therapy. Eur. J. Med. Res. 25:1999;43-53.
7. Mailloux A., Grenet K., Bruneel A., Beneteau-Burnat B., Vaubourdolle M., Baudin B. Anticancer drugs induce necrosis of human endothelial cells involving both oncosis and apoptosis. Eur. J. Cell Biol. 80:2001;442-449.
8. Hamilton R.F., Li L., Felder T.B., Holian A. Bleomycin induces apoptosis in human alveolar macrophages. Am. J. Physiol. 269:1995;L318-L325.
9. Tang D.G., Li L., Zhu Z., Joshi B. Apoptosis in the absence of cytochrome c accumulation in the cytosol. Biochem. Biophys. Res. Commun. 242:1998;380-384.
10. Kuwano K., Kunitake R., Maeyama T., Hagimoto N., Kawasaki M., Matsuba T., Yoshimi M., Inoshima I., Yoshida K., Hara N. Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor. Am. J. Physiol. (Lung Cell Mol. Physiol.). 280:2001;L316-L325.
11. Williams G.T. Programmed cell death: apoptosis and oncogenesis. Cell. 65:1991;1097-1098.
12. Iyer R., Holian A. Involvement of the ICE family of proteases in silica-induced apoptosis in human alveolar macrophages. Am. J. Physiol. 273:1997;L760-L767.
13. Shi X., Castranova V., Halliwell B., Vallyathan V. Reactive oxygen species and silica-induced carcinogenesis. J. Toxicol. Environ. Health. 1:1998;181-197.
14. Burger R.M., Projan S.J., Horwitz S.B., Peisach J. The DNA cleavage mechanism of iron-bleomycin. Kinetic resolution of strand scission from base propenal release. J. Biol. Chem. 261:1986;15955-15959.
15. Conklin K.A. Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutr. Cancer. 37:2000;1-18.
16. Wauer R.R., Schmalisch G., Bohme B., Arand J., Lehmann D. Randomized double blind trial of ambroxol for the treatment of respiratory distress syndrome. Eur. J. Pediatr. 151:1992;357-363.
17. Fegiz G. Prevention by ambroxol of bronchopulmonary complications after upper abdominal surgery: double-blind Italian multicenter clinical study versus placebo. Lung. 169:1991;69-76.
18. Cho Y., Jang Y.Y., Han E.S., Lee C.S. The inhibitory effect of ambroxol on hypochlorous acid-induced tissue damage and respiratory burst of phagocytic cells. Eur. J. Pharmacol. 383:1999;83-91.
19. Gillissen A., Nowak D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy. Resp. Med. 92:1998;609-623.
20. Kim Y.K., Jang Y.Y., Han E.S., Lee C.S. Depressant effect of ambroxol on stimulated functional responses and cell death in rat alveolar macrophages exposed to silica in vitro. J. Pharmacol. Exp. Ther. 300:2002;629-637.
21. Bernardi P. The permeability transition pore. Control points of a cyclosporine A-sensitive mitochondrial channel involved in cell death. Biochim. Biophys. Acta. 1275:1996;5-9.
22. Chandra J., Samali A., Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 29:2000;323-333.
23. Chakraborati T., Das S., Mondal M., Roychoudhury S., Chakraborati S. Oxidant, mitochondria and calcium: an overview. Cell Signal. 11:1999;77-85.
24. Luisetti M., Poena V., Salmona M., Pagnoni A.M., Villani F., Knerich R., Genghini M., Abba L., Pozzi E. Ambroxol and pulmonary toxicity induced by antineoplastic drugs. Int. J. Clin. Pharmacol. Res. 6:1986;129-136.
25. Stettner S., Ledwoztw A. The effect of ambroxol on bleomycin-induced changes in phospholipid composition of rat lung surfactant. Acta Physiol. Lung. 83:1995;181-187.
26. Moreno A.J.M., Madeira V.M.C. Mitochondrial biogenetics as affected by DTT. Biochim. Biophys. Acta. 1060:1991;166-174.
27. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
28. Oberhammer F.A., Pavelka M., Sharma S., Tiefenbacher R., Purchio A.F., Bursch W., Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5408-5412.
29. Lotharius J., Dugan L.L., O'Malley K.L. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J. Neurosci. 19:1999;1284-1293.
30. Isenberg J.S., Klaunig J.E. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicol. Sci. 53:2000;340-351.
31. Lizard G., Miguet C., Bessede G., Monier S., Gueldry S., Neel D., Gambert P. Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. Free Radic. Biol. Med. 28:2000;743-753.
32. Fu W., Luo H., Parthasarathy S., Mattson M.P. Catecholamines potentiate amyloid β-peptide neurotoxicity: involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis. Neurobiol. Dis. 5:1998;229-243.
33. van Klaveren R.J., Hoet P.H.M., Pype J.L., Demedts M., Nemery B. Increase in γ-glutamyltransferase by glutathione depletion in rat type II pneumocytes. Free Radic. Biol. Med. 22:1997;525-534.
34. Gutteridge J.M.C., Rowley D.A., Halliwell B. Superoxide dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of 'catalytic' iron and anti-oxidant activity in extracellular fluids. Biochem. J. 201:1982;605-609.
35. Halliwell B, Gutteridge JMC. Antioxidant defences. In: Halliwell B, Gutteridge JMC, editors. Free radicals in biology and medicine, 3rd ed. New York: Oxford University Press; 1999. p. 105-245.
36. Levine R.L., Garland D., Oliver C.N., Amici A., Climent I., Lenz A.-G., Ahn B.-W., Shaltiel S., Stadman E.R. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186:1993;464-478.
37. Aruoma O.I. Deoxyribose assay for detecting hydroxyl radicals. Methods Enzymol. 233:1994;57-66.
38. Stennicke H.R., Salvesen G.S. Caspases: preparation and characterization. Companion Methods Enzymol. 17:1999;313-319.
39. Rahman Q., Abidi P., Afaq F., Schiffmann D., Mossman B.T., Kamp D.W., Athar M. Glutathione redox system in oxidative lung injury. Crit. Rev. Toxicol. 29:1999;543-568.
40. Jurma O.P., Hom D.G., Andersen J.K. Decreased glutathione results in calcium-mediated cell death in PC12. Free Radic. Biol. Med. 23:1997;1055-1066.
41. Pryor W.A., Squadrito G.L. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol. 268:1995;L699-L722.
42. Hagimoto N., Kuwano K., Nomoto Y., Kunitake R., Hara N. Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Cell Mol. Biol. 16:1997;91-101.
43. Xu M., Ashraf M. Melatonin protection against lethal myocyte injury induced by doxorubicin as reflected by effects on mitochondrial membrane potential. J. Mol. Cell Cardiol. 34:2002;75-79.
44. Amarante-Mendes G.P., Kim C.N., Liu L., Huang Y., Perkins C.L., Green D.R., Bhalla K. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockade of mitochondrial release of cytochrome c and activation of caspase-3. Blood. 91:1998;1700-1705.
45. Zamzami N., Hirsch T., Dallaporta B., Petit P.X., Kroemer G. Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J. Bioenerg. Biomembr. 29:1997;185-193.
46. Tan S., Sagara Y., Liu Y., Maher P., Schubert D. The regulation of reactive oxygen species production during programmed cell death. J. Cell Biol. 141:1998;1423-1432.
47. Garcia-Ruiz C., Colell A., Morales A., Laplowitz N., Fernandez-Checa J.C. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol. Pharmacol. 48:1995;825-834.
48. Gurujeyalakshmi G., Wang Y., Giri S.N. Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin. Nitric Oxide. 4:2000;399-411.
49. Punithavathi D., Venkatesan N., Babu M. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br. J. Pharmacol. 131:2000;169-172.
50. Gillissen A., Bartling A., Schoen S., Schultze-Werninghaus G. Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung. 175:1997;235-242.